Characterization of rat brain cellular membrane components acting as receptors for vesicular stomatitis virus. Brief report.

Abstract:

:The chemical nature of the binding sites for vesicular stomatitis virus (VSV) was studied by measuring the ability of solubilized rat brain cell membranes (SRBM) to compete with cultured cells for viral binding. SRBM significantly reduced both binding and infectivity of VSV. After separation of protein and lipid components from membranes, VSV infection was unaffected by the protein fraction, whereas the lipid moiety, specifically phospholipids and glycolipids, showed a dose-dependent inhibitory effect. The essential role of phospholipid and sialic acid-containing glycolipid molecules as receptors for VSV was also suggested by the sensitivity of the inhibitory activity of SRBM and lipid components to phospholipase C and neuraminidase digestion.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Conti C,Mastromarino P,Ciuffarella MG,Orsi N

doi

10.1007/BF01311075

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

261-9

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

99

pub_type

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