Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus.

Abstract:

:Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log10 genomic equivalents [GE] of OH-FD22-P5; n=4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log10 GE of PC21A; n=3). In PDCoV-inoculated calves, an acute but persisting fecal viral RNA shedding and PDCoV-specific serum IgG antibody responses were observed, but without lesions or clinical disease. However, no fecal shedding, seroconversion, histological lesions, and clinical disease were detected in PEDV-inoculated calves. Our data indicate that calves are susceptible to infection by the newly emerged PDCoV, but not by the swine coronavirus, PEDV.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Jung K,Hu H,Saif LJ

doi

10.1007/s00705-017-3351-z

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

2357-2362

issue

8

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-017-3351-z

journal_volume

162

pub_type

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