Abstract:
:Viral infections of the central nervous system (CNS) following peripheral inoculation of Sindbis viruses were studied. The use of viral strains, which vary in their neuroinvasive and neurovirulent properties, and various strains of mice, which differ in immunocompetence, revealed several pathways of viral neuroinvasion in adult mice. A genetic-trait dependent mechanism was exhibited by the neuroinvasive viruses, showing a similar pattern in all mice strains tested. A second mechanism, dependent on a prolonged high viral load, was exhibited by a noninvasive variant in Severe Combined ImmunoDeficient (SCID) mice. The absence of antiviral antibodies in SCID mice allowed the maintenance of a long-term high viremia, leading to a random entry to the CNS and proliferation in brain tissue. An additional pathway for neuroinvasion was induced upon disruption of the blood-brain barrier activity by exogenous reagents and was demonstrated in cases of short lived high viremia of noninvasive viruses.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Lustig S,Halevy M,Ben-Nathan D,Rice CM,Kobiler Ddoi
10.1007/s007050050576keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1159-71issue
6eissn
0304-8608issn
1432-8798journal_volume
144pub_type
杂志文章abstract::Nine pestiviruses isolated from different batches of a contaminated Tunisian sheep pox vaccine and one Tunisian field ovine isolate of border disease virus (BDV) were studied at the antigenic and molecular levels. Seroneutralization tests were carried out on three vaccine isolates, the Tunisian field isolate and repre...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-004-0427-3
更新日期:2005-02-01 00:00:00
abstract::Poultry production is an important sector of agriculture in Sri Lanka; however, there is a lack of information regarding circulation of infectious bronchitis virus (IBV). RNA was extracted from chicken tissues, subjected to IBV S1 RT-PCR, and sequenced. Overall, 19 out of 34 (55.88 %) samples were IBV positive and con...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-016-2831-x
更新日期:2016-06-01 00:00:00
abstract::To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01718634
更新日期:1996-01-01 00:00:00
abstract::Papaya sticky disease ('meleira') was first observed in Brazil at the beginning of the 1980s. The disease is characterized by intense latex exudation from the fruit surface that becomes dark as it oxidizes, which makes it difficult to sell. The causal agent, which has been called papaya meleira virus (PMeV), has been ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-015-2605-x
更新日期:2015-12-01 00:00:00
abstract::Here, we present the complete genomic sequence of duck enteritis virus (DEV) strain SD, isolated in China in 2012. The virus was virulent in experimentally infected 2-month-old ducks. The DEV SD genome is 160,945 base pairs (bp) in length. The viral genome sequence, when compared to that of strain DEV CSC, which was i...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-020-04594-7
更新日期:2020-07-01 00:00:00
abstract::The complete nucleotide sequence of the viral protein 2 (VP2) ORF was determined for 26 Vietnamese infectious bursal disease isolates collected from clinical outbreaks in vaccinated flocks from 1987 to 2018 and two commercial vaccine specimens. These sequences were compared for molecular classification with 42 referen...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04287-w
更新日期:2019-08-01 00:00:00
abstract::Peach asteroid spot (PAS) and peach sooty ringspot (PSRS) are two diseases of stone fruit trees of unknown aetiology. The use of a cRNA probe of the newly described Apricot latent virus (ApLV), a tentative member of the Foveavirus genus, indicated the presence of cross-hybridizing agents in PAS isolate LA2 and in PSRS...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050170071
更新日期:2001-08-01 00:00:00
abstract::Tissues of the central nervous system (CNS) of cynomolgus monkeys were examined by electron microscopy after intraspinal inoculation of enterovirus 71 (E71). A characteristic finding was the appearance of numerous membrane-bound vesicles (Mbvs) in affected motoneurons. Similar Mbvs were also present in E71-infected cy...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01314120
更新日期:1985-01-01 00:00:00
abstract::A type III Trichomonas vaginalis virus, which may be involved in transcriptional regulation of the major surface protein gene P270 of the protozoan pathogen Trichomonas vaginalis, was purified and characterized in the present study. The complete 4844-base-pair complementary DNA sequence of the viral genome reveals ove...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-010-0858-y
更新日期:2011-02-01 00:00:00
abstract::A simultaneous decay of the expression of Im 140 kDa, Im 150 kDa and Im 160 kDa high MW membrane antigens, concomitant with the cell proliferation arrest, was observed during erythropoietin induced differentiation of ts 34 AEV-transformed erythroid cells cultivated at the restrictive temperature. Expression of embryo-...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310975
更新日期:1987-01-01 00:00:00
abstract::Six isolates of Suid herpesvirus 1 (SHV-1) collected from clinical outbreaks of Aujeszky's disease (AD) in Jutland in January-February, 1985, were compared by restriction fragment pattern (RFP) analyses with older SHV-1 isolates from Jutland as well as with SHV-1 isolates from different parts of West Germany and Irela...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310912
更新日期:1988-01-01 00:00:00
abstract::A novel iflavirus, tentatively named "Sogatella furcifera honeydew virus 1" (SFHV1), discovered through transcriptome sequencing analysis of white-backed planthoppers (Sogatella furcifera) collected in southern China, is described here. The full genome of SFHV1 is 10,837 nucleotides (nt) long, including the polyA tail...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-3817-7
更新日期:2018-07-01 00:00:00
abstract::An Indonesian very virulent (vv) strain of infectious bursal disease virus (IBDV), designated Tasik94, was characterised both in vivo and at the molecular level. Inoculation of Tasik94 into 5-week-old specific-pathogen-free (SPF) chickens resulted in 100% morbidity and 45% mortality. The complete nucleotide and predic...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-002-0817-3
更新日期:2002-07-01 00:00:00
abstract::By means of indirect immunofluorescence assay (IFA) using natural swine immune serum and hyperimmune serum from rabbits infected with porcine circovirus (PCV), a PCV antigen was detected present prior to the onset of viral and cellular DNA synthesis in nucleoli of cells of synchronized and growth stimulated infected P...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01384343
更新日期:1995-01-01 00:00:00
abstract::The genome of Duck circovirus (DuCV) is circular and 1996 nts in size. Two major open reading frames were identified, encoding the replicase (V1) and the capsid protein (C1). A stem-loop structure comprising the nonamer 5'-TATTATTAC, conserved in all circo-, nano- and geminiviruses, was found. Unique to DuCV, the regi...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-003-0181-y
更新日期:2003-12-01 00:00:00
abstract::In a virus-infected plant, small interfering RNAs (siRNAs) corresponding to the viral genome form a large proportion of the small RNA population. It is possible to reassemble significant portions of the virus sequence from overlapping siRNA sequences and use these to identify the virus. We tested this technique with a...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-011-0979-y
更新日期:2011-07-01 00:00:00
abstract::The acid-extractable leaf proteins of potato spindle tuber viroid (PSTV) infected tomato plants were analysed electrophoretically on polyacrylamide gels. The most prominent alteration found during disease development was the appearance of a "pathogenesis-related" protein with an apparent molecular weight of 14,000 (ca...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309998
更新日期:1984-01-01 00:00:00
abstract::Classical serotype 1 infectious bursal disease viruses (IBDV), but not very virulent (vv) isolates, react with neutralizing monoclonal antibody (NMab) 3 in virus neutralization tests or antigen-capture ELISA. Two other NMabs, 6 and 8, bind to both classical and most vv strains, but not to the atypical 94,432 and 91,16...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050404
更新日期:1998-01-01 00:00:00
abstract::Manipulation of African swine fever virus (ASFV) genomes, in particular those from field strains, is still a challenge. We have shown recently that generation of a green-fluorescent-protein-expressing, thymidine-kinase-negative (TK-) mutant of the low-pathogenic African swine fever virus field strain NHV was supported...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-014-2095-2
更新日期:2014-09-01 00:00:00
abstract::Five cDNA probes prepared from molecular clones representing genomic RNA sequences of the virulent Miller strain of transmissible gastroenteritis virus (TGEV) were used in a dot blot hybridization assay to detect TGEV in cell culture and fecal specimens. Two clones (pA2 and pB4) represent nucleotide base pairs at the ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01319234
更新日期:1991-01-01 00:00:00
abstract::Rotavirus (RV) is the primary cause of severe dehydrating gastroenteritis and acute diarrheal disease in infants and young children. Previous studies have revealed that genistein can inhibit the infectivity of enveloped or nonenveloped viruses. Although the biological properties of genistein are well studied, the mech...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-015-2404-4
更新日期:2015-06-01 00:00:00
abstract::We studied the kinetics of localisation of matrix (M) protein of Human respiratory syncytial virus (RSV) in infected cells. M protein was detected in the nucleus early in infection, by confocal microscopy and by immunoblotting of nuclear fractions. We next tested the possibility that M protein may be involved in inhib...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-003-0112-y
更新日期:2003-07-01 00:00:00
abstract::Evidence is presented that the excess pool of penton complexes purified from adenovirus type 1-infected HEp-2 cells also carry an endonucleolytic activity. The effect was measured with both E. coli and adenovirus type 1 double-stranded DNA substrates. The use of agarose gels for assaying the endonuclease activity allo...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01315620
更新日期:1976-01-01 00:00:00
abstract::A total of 34 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) strains isolated from Vietnam during 2013-2014 were sequenced and analyzed. A partial sequence of ORF1a corresponding to the nonstructural protein 2 (Nsp2) coding region and the full sequence of open reading frame 5 (ORF5) g...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-015-2699-1
更新日期:2016-03-01 00:00:00
abstract::Genomic DNA of blueberry red ringspot virus (genus Soymovirus, family Caulimoviridae) from highbush blueberry plants growing for years in the Czech Republic and Slovenia was sequenced. The circular dsDNA genomes consist of 8,303 and 8,299 nt, respectively, and contain eight open reading frames (ORFs) longer than 100 a...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-011-1077-x
更新日期:2011-10-01 00:00:00
abstract::Noroviruses, a major cause of acute gastroenteritis outbreaks worldwide, are constantly evolving. This ability is reflected in the speed and efficiency with which these viruses spread and remain in the human population. The present study reports the detection of a novel recombination event among norovirus genotypes in...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1428-2
更新日期:2012-12-01 00:00:00
abstract::Porcine circovirus type 2 (PCV2) is the etiological agent associated with several pig diseases that are collectively referred to as porcine circovirus-associated disease (PCVAD). Unfortunately, PCV2 has had a serious economic impact on the swine industry. In this study, we report the genome sequence of a novel PCV2 is...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-015-2615-8
更新日期:2015-12-01 00:00:00
abstract::Sixteen patients with symptoms typical for Ockelbo disease (rash, arthralgia, fever) were enrolled in a 2 1/2 year study, during which clinical symptoms were recorded and ELISA was employed to study specific IgM, IgG and IgG subclass development. Initially, all patients presented with rash and arthralgia, and five pat...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01379107
更新日期:1994-01-01 00:00:00
abstract::The complete genome of a novel mycovirus, Puccinia striiformis mitovirus 1 (PsMV1), derived from the wheat stripe rust fungus Puccinia striiformis strain SCSN-10, was sequenced and analyzed. The full-length cDNA sequence is 2496 bp in length with a predicted AU content of 57.65% in the genomic RNA. Sequence analysis i...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-04134-4
更新日期:2019-03-01 00:00:00
abstract::DNA polymerase (DNApol) is highly conserved in all baculoviruses and plays an essential role in viral DNA replication. Previous results showed that the DNApol of the betabaculovirus Pieris rapae granulovirus (PiraGV) can localize in the nucleus. However, it is not clear how the DNApol is transported into the nucleus. ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-4115-0
更新日期:2019-03-01 00:00:00