Oncogenicity of heat-inactivated simian adenovirus SA7.

Abstract:

:Simian adenovirus SA7 heated for 30 minutes at 70 degrees C retained part of its ability to induce tumors in newborn hamsters. Tumors were also induced by DNA extracted from the heated virus. However, neither residual replicating, i.e. cytopathogenic, nor transforming and T-antigen-inducing activities could be detected in vitro in CV-1 and hamster embryo cells inoculated with the heated virus. The results are discussed in terms of a possible release of viral nucleic acid at the high temperature. They also show that current tests for effective virus inactivation based exclusively on the recognition of replicating virus should be reevaluated.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Soboll H,Fenyves A,Strupp L

doi

10.1007/BF01317334

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

189-96

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

69

pub_type

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