Effect of DEAE-dextran on protein synthesis in HeLa cells.

Abstract:

:Concentrations of DEAE-dextran which are currently used to stimulate the interaction between animal cells and natural or synthetic polynucleotides, inhibit protein synthesis in HeLa cells. This inhibition results from the blocking of more than one of the steps in protein synthesis, including transport of amino acids. The results support the hypothesis that enhancement of cellular competence for infection by viral RNA involves interference with initiation of cellular protein synthesis.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Saborio JL,Wiegers KJ,Koch G

doi

10.1007/BF02175599

keywords:

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

81-7

issue

1

eissn

0304-8608

issn

1432-8798

journal_volume

49

pub_type

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