Abstract:
:To test the role of neutralizing antibodies (nAbs) and receptor adaptation in interspecies transmission of influenza virus, two H5N1 strains, isolated from human and avian hosts, with four amino acid differences in hemagglutinin (HA) and seven HA mutations were studied. We found that a mutation at amino acid position 90 in the H5N1 HA, outside the receptor-binding domain (RBD), could simultaneously induce changes in the RBD conformation to escape from nAb binding and alter the receptor preference through long-range regulation. This mutation was deemed a "key event" for interspecies transmission. It is likely a result of positive selection caused by antibodies, allowing the original invasion by new species-specific variants. A mutation at amino acid position 160 in the RBD only induced a change in receptor preference. This mutation was deemed a "maintaining adaptation", which ensured that influenza virus variants would be able to infect new organisms of a different species successfully. The mutation is the result of adaptation caused by the receptor. Our results suggest that continuing occurrence of these two types of mutations made the variants persist in the new host species.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Li Z,Liu Z,Ma C,Zhang L,Su Y,Gao GF,Li Z,Cui L,He Wdoi
10.1007/s00705-011-1056-2subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1803-12issue
10eissn
0304-8608issn
1432-8798journal_volume
156pub_type
杂志文章abstract::PCR products representing c. 550 3' terminal bases of Beet soil-borne pomovirus (BSBV) RNA 3 were compared for sources of this virus from all major sugarbeet-growing areas in Germany. In none of these areas conspicious symptoms could be attributed to the presence of BSBV. Single strand conformation polymorphism analys...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050070117
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310998
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-016-2986-5
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journal_title:Archives of virology
pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1597-z
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050332
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pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309956
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pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310727
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00705-011-1091-z
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pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
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