Abstract：
:Herpes simplex virus type 2 (HSV-2), strain YS-4 C-1, isolated by plaque cloning from a clinical isolate was found to be resistant to acyclovir (ACV; acycloguanosine) in vitro. It was sensitive to phosphonoacetic acid and 9-beta-D-arabinofuranosyladenine. Thymidine kinase (TK) activity of YS-4 C-1 was less than 1% of that of other strains from the same clinical source. However, thymidine plaque autoradiography showed that YS-4 C-1 was not completely deficient in TK activity. YS-4 C-1 showed high virulence for mice like other HSV-2 strains which were sensitive to ACV. YS-4 C-1 was able to establish latent infection in mice. Virus isolated from the brain of a mouse died after being inoculated with YS-4 C-1 was also resistant to ACV. ACV was not effective in mice inoculated with YS-4 C-1. This study shows that not all ACV-resistant strains are avirulent for mice.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Sakuma S,Yamamoto M,Kumano Y,Mori Rdoi
10.1007/BF01310998subject
Has Abstractpub_date
1988-01-01 00:00:00pages
169-82issue
3-4eissn
0304-8608issn
1432-8798journal_volume
101pub_type
杂志文章abstract：:Porcine epidemic diarrhea virus (PEDV) causes significant loss to the swine industry. The emergence of novel PEDV strains in recent years has decreased the effectiveness of PEDV vaccines. We have developed a live recombinant vaccine, a swinepox virus vector that expresses a truncated S protein (rSPV-St) from a recent ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-017-3548-1
更新日期：2017-12-01 00:00:00
abstract：:Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are two closely related alphaherpesviruses. BoHV-1 causes several syndromes in cattle, including respiratory disease and sporadic cases of encephalitis, whereas BoHV-5 is responsible for meningoencephalitis in calves. Although both viruses are neurotropic, they differ...
journal_title：Archives of virology
pub_type： 杂志文章,评审
doi：10.1007/s00705-019-04494-5
更新日期：2020-02-01 00:00:00
abstract：:A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317202
更新日期：1992-01-01 00:00:00
abstract：:The objective of this study was to test the ability of bovine viral diarrhea virus (BVDV) to infect mice. Two mice each were either mock infected or inoculated with one of three BVDV strains by the intraperitoneal (IP) (n = 8) or intranasal (IN) (n = 8) route. All mice were euthanized at day 7 postinfection (p.i.). No...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2412-4
更新日期：2015-06-01 00:00:00
abstract：:Bacterial endotoxins, DNA, live viruses, and viral proteins derived from bacterial and baculovirus (BV) expression vectors employed in recombinant protein production contaminate the final product. Density gradient centrifugation is commonly used to partially purify oligomeric proteins, but impurities from the expressi...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2991-8
更新日期：2016-11-01 00:00:00
abstract：:Human adenoviruses (HAdV) of species B, C, and E (HAdV-B, -C, -E) are frequent causative agents of acute respiratory infections worldwide. No specific analysis has been done on the epidemiological and clinical features of HAdV in pediatric pneumonia in China. Nasopharyngeal aspirates were collected from hospitalized c...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2308-8
更新日期：2015-03-01 00:00:00
abstract：:A quasi-spherical virus was isolated from a cultivated Amazon lily plant (Eucharis grandiflora) that could be mechanically transmitted to healthy E. grandiflora plants, subsequently producing mild mosaic or mottle symptoms on the leaves. The purified virus consisted of three quasi-spherical particles about 20 nm wide ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1467-8
更新日期：2013-01-01 00:00:00
abstract：:The complete genome sequence of a Chinese very virulent infectious bursal disease virus (vvIBDV) strain, Harbin-1, was determined. Based on the sequence analysis, the molecular characteristics and potential virulence determinants and origin of vvIBDV strains were identified. Phylogenetic analysis indicated that a reas...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0140-8
更新日期：2008-01-01 00:00:00
abstract：:The complete genome sequence of a severe isolate of broad bean true mosaic virus (genus Comovirus, subfamily Comovirinae, family Secoviridae) is presented. Comparison of the amino acid sequences of the capsid proteins and the polymerase showed striking differences to other comoviruses and highest similarities to legum...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0668-2
更新日期：2010-07-01 00:00:00
abstract：:The nucleotide sequence of the coat protein cistron of an Austrian isolate of grapevine fanleaf virus (GFLV-FC) from Vitis vinifera cv. French Colombard was determined. It shows small differences at the RNA level as well as at the protein level compared to the sequences of already published grapevine fanleaf virus str...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309730
更新日期：1995-01-01 00:00:00
abstract：:The exact intracellular site of hepatitis A virus (HAV) production is unknown, possibly due to its usually slow and inefficient replication. Using immunocytochemistry and in-situ RT-PCR, we show that in cells infected with the rapidly replicating HAV strain HAS-15, viral proteins and RNA are scattered throughout the c...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170003
更新日期：2001-12-01 00:00:00
abstract：:The effects of relative humidity and temperature on the survival of human rotavirus in a thin layer of faeces on an impervious surface and on absorbent material was investigated using the indirect immunofluorescence technique in LLC-MK2 cells to titrate infectivity. Rotavirus was found to be very stable at low and hig...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01348963
更新日期：1982-01-01 00:00:00
abstract：:Scutellaria baicalensis Georgi, a Chinese herbal decoction, has been used for the treatment of the common cold, fever and influenza virus infections. In previous studies, we found that oral administration of baicalein resulted in the inhibition of influenza A virus replication in vivo, which was linked to baicalin in ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2192-2
更新日期：2014-12-01 00:00:00
abstract：:We analyzed retrospectively a relative risk of measles attacks in vaccinated vs. unvaccinated students using two independent outbreaks in Japan. The first involved 33/328 (10%) students where 64% students and 30% measles cases had been vaccinated. The second involved 27/241 (11%) students where 81% students and 48% me...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309868
更新日期：1995-01-01 00:00:00
abstract：:The nucleotide sequences of the entire F genes of two isolates of the pigeon PMV-1 (PPMV-1) variant of Newcastle disease virus (NDV) were determined using RTPCR. The deduced amino acid sequences of the F0 protein showed four differences between isolate 760/83 which had been passaged 4 times in chickens and gave an int...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01718322
更新日期：1996-01-01 00:00:00
abstract：:We present here the results of the analysis of the complete genome sequence of a lytic bacteriophage, vB_ButM_GuL6, which is the first virus isolated from Buttiauxella. Electron microscopy revealed that vB_ButM_GuL6 belongs to the family Myoviridae, order Caudovirales. The genome of vB_ButM_GuL6 is a linear, circularl...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04780-7
更新日期：2020-11-01 00:00:00
abstract：:The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by sequencing and phylogenetic ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-006-0910-0
更新日期：2007-01-01 00:00:00
abstract：:In this study, we calculated the relative synonymous codon usage (RSCU) value and the effective number of codons (ENC) value to carry out principal component analysis (PCA) and correlation analysis of the codon usage pattern of the phosphoprotein gene (P gene) of spring viraemia of carp virus (SVCV). The synonymous co...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2000-z
更新日期：2014-07-01 00:00:00
abstract：:Codiaeum variegatum (common name, garden croton) is an ornamental plant grown for its bright yellow variegated leaf morphology. Two C. variegatum plants with upward leaf curling and vein swelling symptoms were collected in Faisalabad, Pakistan. Sequencing of clones obtained by PCR amplification with specific primers s...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04633-3
更新日期：2020-08-01 00:00:00
abstract：:Recently we have described that the Herpes simplex virus (HSV)-induced thymidine kinase (TK) induces AMP- and ADP-dThd-5'-phosphotransferase activities. We now demonstrate the heterogeneity of the described activities in isoelectric focusing experiments and polyacrylamide gel electrophoresis. A TK--mutant of HSV type ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314875
更新日期：1982-01-01 00:00:00
abstract：:We previously reported the isolation of South River virus (SORV) from a pool of mosquitoes collected in the Yucatan Peninsula of Mexico (Farfan-Ale et al. in Vector Borne Zoonotic Dis 10:777-783, 5). The isolate (designated SORV-252) was identified as SORV after a 197-nucleotide region of its small RNA genome segment ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1280-4
更新日期：2012-06-01 00:00:00
abstract：:We have examined by immunofluorescent antibody staining technique the expression of herpes simplex virus type 1 (HSV-1) in organ cultures of the normal human oral mucosa. The expression of HSV-1 antigen was found selectively in the epithelial cell layers in relatively undifferentiated states such as basal layer and lo...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310061
更新日期：1987-01-01 00:00:00
abstract：:Use of Urografin and Conray for the equilibrium centrifugation of viruses is described. These pharmaceuticals, which consist of iodinated arylic compounds, reach densities of 1.6 g/cm3 and have low intrinsic viscosities. Poliovirus, Newcastle disease virus, and lymphocytic choriomeningitis virus were centrifuged to eq...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318245
更新日期：1975-01-01 00:00:00
abstract：:Porcine noroviruses (NoVs) and sapoviruses (SaVs), which belong to the family Caliciviridae, have been considered potential zoonotic agents for human infection, and several cases have been reported in Asian countries. In this study, a total of 537 porcine fecal samples collected from 64 swine farms in Korea were teste...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0501-y
更新日期：2009-01-01 00:00:00
abstract：:TT virus (TTV), the first human circovirus to be discovered, appears to be present in most people; less is known about the prevalence of the related TTV-like mini virus (TLMV). A sensitive nested PCR, specific for TLMV, detected the virus in 48% of 201 sera (Norwegian blood donors) previously found to have a 90% preva...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s705-002-8310-6
更新日期：2002-01-01 00:00:00
abstract：:A real-time PCR assay based on primer-probe energy transfer (PriProET) was developed to detect swine vesicular disease virus (SVDV). Specificity tests of SVDV and heterologous virus showed specific amplification of SVDV strains only. The amplification plot for the closely related Coxsackievirus B5 remained negative. T...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-006-0817-9
更新日期：2006-12-01 00:00:00
abstract：:Mouse L-cells infected with UV-inactivated HSV could serve as suitable targets for monitoring H-2 restricted cytotoxicity mediated by HSV-immune T cells. Cytotoxic potential of immune T cells for H-2 compatible targets exposed to UV-inactivated HSV was enhanced if the later were pretreated with mouse interferon. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315679
更新日期：1978-01-01 00:00:00
abstract：:Human adenoviruses (Ad) 5 and 7 multiplied poorly in guinea-pig cell cultures as compared to HeLa cells. Ad 7 had a modified polypeptide composition with a major 43K component. This change persisted for up to 4 passages in HeLa cells. Ad 5 was not changed by passage in guinea-pig cells. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01320631
更新日期：1980-01-01 00:00:00
abstract：:Wheat streak mosaic virus is a serious threat in wheat-producing countries. In Germany, the virus was first recorded in 2013 near Hoym. The complete sequence of isolate Hoym was obtained and compared to all other known complete WSMV sequences, including newly collected and sequenced isolates from France and Austria. P...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2422-2
更新日期：2015-07-01 00:00:00
abstract：:Hepatitis B virus (HBV) circulates as a collection of genetically related variants that evolve throughout the chronic infection. Those viral variants that have the greatest fitness are fixed. We recently showed different fitness for HBV variants involved in two epidemiological situations. To understand these fitness d...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4090-5
更新日期：2019-02-01 00:00:00
