An acyclovir-resistant strain of herpes simplex virus type 2 which is highly virulent for mice.


:Herpes simplex virus type 2 (HSV-2), strain YS-4 C-1, isolated by plaque cloning from a clinical isolate was found to be resistant to acyclovir (ACV; acycloguanosine) in vitro. It was sensitive to phosphonoacetic acid and 9-beta-D-arabinofuranosyladenine. Thymidine kinase (TK) activity of YS-4 C-1 was less than 1% of that of other strains from the same clinical source. However, thymidine plaque autoradiography showed that YS-4 C-1 was not completely deficient in TK activity. YS-4 C-1 showed high virulence for mice like other HSV-2 strains which were sensitive to ACV. YS-4 C-1 was able to establish latent infection in mice. Virus isolated from the brain of a mouse died after being inoculated with YS-4 C-1 was also resistant to ACV. ACV was not effective in mice inoculated with YS-4 C-1. This study shows that not all ACV-resistant strains are avirulent for mice.


Arch Virol


Archives of virology


Sakuma S,Yamamoto M,Kumano Y,Mori R




Has Abstract


1988-01-01 00:00:00












  • O/SEA/Mya-98 lineage foot-and-mouth disease virus was responsible for an extensive epidemic that occurred in late 2018 in Vietnam.

    abstract::Since late 2018, foot-and-mouth disease (FMD) has reemerged and rapidly swept through pig farms in North and Central Vietnam, despite widespread use of commercial FMD vaccines. To investigate the FMD virus (FMDV) strains responsible for the current epidemics, 40 FMDV samples were collected from 17 provinces during Nov...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Van Diep N,Ngoc TTB,Hoa LQ,Nga BTT,Kang B,Oh J,Lan NT,Le VP

    更新日期:2020-11-01 00:00:00

  • Molecular diversity of the coat protein-encoding region of Barley yellow dwarf virus-PAV and Barley yellow dwarf virus-MAV from Latvia and Sweden.

    abstract::The sequence variability of Barley yellow dwarf virus-PAV (PAV) and Barley yellow dwarf virus-MAV (MAV) was studied by comparing 502 nucleotides from the coat protein-encoding region of six isolates from Latvia and four from Sweden. The diversity within MAV was low (>97% sequence identity), also when compared to isola...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Bisnieks M,Kvarnheden A,Sigvald R,Valkonen JP

    更新日期:2004-04-01 00:00:00

  • Detection of hepatitis E virus in slaughtered pigs in Italy.

    abstract::The stools of slaughtered pigs were screened for hepatitis E virus (HEV). HEV RNA was detected in 7.3% of the samples. HEV strains were characterized as genotype 3 subtype c, a cluster previously not described in Italy. These findings provide evidence that slaughterhouse workers may be exposed to HEV infection. ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Di Martino B,Di Profio F,Martella V,Di Felice E,Di Francesco CE,Ceci C,Marsilio F

    更新日期:2010-01-01 00:00:00

  • Molecular characterization of a distinct begomovirus infecting tobacco in Yunnan, China.

    abstract::Virus isolate Y3V, obtained from tobacco showing leaf curl symptoms in Yunnan, China, had particles with the size and morphology typical of geminiviruses. In reactions with a set of monoclonal antibodies raised against begomoviruses, Y3V was readily differentiated from two previously studied Chinese Begomovirus isolat...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Zhou XP,Xie Y,Zhang ZK

    更新日期:2001-08-01 00:00:00

  • Molecular cloning and physical mapping of bovine herpesvirus 4 strain DN 599 and comparison with two American field-isolates.

    abstract::Ninety four percent of the genome of bovine herpesvirus 4 (BHV-4) strain DN 599 was cloned and a physical map was constructed by Southern blot analysis using a library of cloned fragments cleaved with the 3 restriction enzymes (Eco RI, Bam HI, and Hin dIII). The genome length was estimated to be 156.5 kbp +/- 0.7. The...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Shen DT,Burger D,Tong GZ,Gorham JR

    更新日期:1992-01-01 00:00:00

  • Use of Brefeldin A to localize block in intracellular transport of vesicular stomatitis virus G protein on interferon-treated cells.

    abstract::Brefeldin A (BFA) induced a rapid redistribution of vesicular stomatitis virus G protein (VSV-G) to the endoplasmatic reticulum (ER) in interferon (IFN)-pretreated cells. This result is consistent with accumulation of VSV-G in the trans-Golgi (GC) complex in cells pretreated with IFN and implies that IFN does not inte...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Polakova K,Russ G

    更新日期:1992-01-01 00:00:00

  • Experimental infection of Marmota monax with a novel hepatitis A virus.

    abstract::To establish an animal model for the newly identified Marmota Himalayana hepatovirus, MHHAV, so as to develop a better understanding of the infection of hepatitis A viruses. Five experimental woodchucks (Marmota monax) were inoculated intravenously with the purified MHHAV from wild woodchuck feces. One animal injected...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Yu JM,Li LL,Xie GC,Zhang CY,Ao YY,Duan ZJ

    更新日期:2018-05-01 00:00:00

  • Analysis of the beak and feather disease viral genome indicates the existence of several genotypes which have a complex psittacine host specificity.

    abstract::A study was made of the phylogenetic relationships between fifteen complete nucleotide sequences as well as 43 nucleotide sequences of the putative coat protein gene of different strains belonging to the virus species Beak and feather disease virus obtained from 39 individuals of 16 psittacine species. The species inc...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: de Kloet E,de Kloet SR

    更新日期:2004-12-01 00:00:00

  • Hepatitis E virus genotypes 1 and 3 in wastewater samples in Tunisia.

    abstract::Hepatitis E represents an important public-health concern throughout the world. It is one of the leading causes of hepatitis in North Africa, Asia and the Middle East. In Tunisia, the true burden of HEV infection is still unknown. The objectives of the present study were to assess the occurrence of hepatitis E virus i...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Béji-Hamza A,Hassine-Zaafrane M,Khélifi-Gharbi H,Della Libera S,Iaconelli M,Muscillo M,Petricca S,Ciccaglione AR,Bruni R,Taffon S,Aouni M,La Rosa G

    更新日期:2015-01-01 00:00:00

  • qPCR assay for the detection of pseudocowpox virus.

    abstract::Pseudocowpox is a zoonosis caused by pseudocowpox virus (PCPV), which mainly affects cows but can be an occupational disease of humans. The aim of the study was to validate a quantitative polymerase chain reaction (qPCR) assay for the detection of PCPV. The assay was able to detect up to 1000 copies of PCPV per µL in ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: de Oliveira Lopes GA,Ferreira LR,de Souza Trindade G,Fonseca AA Jr,Dos Reis JKP

    更新日期:2021-01-01 00:00:00

  • Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves.

    abstract::Although winter dysentery (WD), which is caused by the bovine coronavirus (BCoV) is characterized by the sudden onset of diarrhea in many adult cattle in a herd, the pathogenesis of the WD-BCoV is not completely understood. In this study, colostrum-deprived calves were experimentally infected with a Korean WD-BCoV str...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Park SJ,Kim GY,Choy HE,Hong YJ,Saif LJ,Jeong JH,Park SI,Kim HH,Kim SK,Shin SS,Kang MI,Cho KO

    更新日期:2007-01-01 00:00:00

  • A molecular taxonomy for cricket paralysis virus including two new isolates from Australian populations of Drosophila (Diptera: Drosophilidae).

    abstract::Two new isolates of cricket paralysis virus, TAR and SIM, are described that were originally isolated from laboratory colonies of Drosophila melanogaster and Drosophila simulans respectively. Using a combination of biological, serological and molecular characters it was possible to distinguish the SIM isolate from all...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Johnson KN,Christian PD

    更新日期:1996-01-01 00:00:00

  • The dengue virus nonstructural protein 1 (NS1) increases NF-κB transcriptional activity in HepG2 cells.

    abstract::Dengue virus nonstructural protein 1 (NS1) is a glycoprotein involved in viral RNA replication. NS1 associates with host cell proteins and can be found in lipid raft domains on the host cell surface, suggesting an involvement in signal transduction events. In this work, we observed that NS1 expression in HepG2 cells i...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Silva BM,Sousa LP,Gomes-Ruiz AC,Leite FG,Teixeira MM,da Fonseca FG,Pimenta PF,Ferreira PC,Kroon EG,Bonjardim CA

    更新日期:2011-07-01 00:00:00

  • Genomic sequence analysis of four new chrysanthemum virus B isolates: evidence of RNA recombination.

    abstract::Chrysanthemums worldwide suffer from a high incidence of infection with chrysanthemum virus B (CVB), a member of the genus Carlavirus, family Betaflexiviridae. Three major lineages or strains of this virus have been found in India, but none have been characterized beyond the genetic variation they display in their coa...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Singh L,Hallan V,Martin DP,Ram R,Zaidi AA

    更新日期:2012-03-01 00:00:00

  • Correction to: Complete genome sequence of a novel bacteriophage, PBKP05, infecting Klebsiella pneumoniae.

    abstract::Unfortunately, the original article was published with incorrect accession number and the correct version is updated here. ...

    journal_title:Archives of virology

    pub_type: 杂志文章,已发布勘误


    authors: Oh HK,Cha K,Hwang YJ,Cho J,Jo Y,Myung H

    更新日期:2019-09-01 00:00:00

  • Comorbidity and high viral load linked to clinical presentation of respiratory human bocavirus infection.

    abstract::Human bocavirus (HBoV) is a new parvovirus associated with acute respiratory tract infection (ARTI). In order to evaluate HBoV significance as an agent of acute respiratory disease, we screened 1,135 respiratory samples from children and adults with and without symptoms during two complete calendar years. HBoV1 preval...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ghietto LM,Majul D,Ferreyra Soaje P,Baumeister E,Avaro M,Insfrán C,Mosca L,Cámara A,Moreno LB,Adamo MP

    更新日期:2015-01-01 00:00:00

  • Quantitative analysis of the Epstein-Barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria.

    abstract::The culture fluids of various anaerobic bacteria induced the synthesis of early antigens (EA) in Epstein-Barr virus (EBV) carrying lymphoblastoid cells. The culture fluids of Corynebacterium butyricum and Fusobacterium nucleatum were the effective inducer on EA. The inducing activity was, to some extent, dependent on ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Asai S,Nakamura Y,Yamamura M,Ikezawa H,Namikawa I

    更新日期:1991-01-01 00:00:00

  • Biosynthesis of measles virus hemagglutinin in persistently infected cells.

    abstract::The synthesis of the hemagglutinin (HA) glycoprotein of measles virus was investigated in a persistently infected cell line using a monoclonal anti-HA. The synthesis of the HA protein was shown to be associated with the rough endoplasmic reticulum. The unglycosylated (HA0) apoprotein is synthesized as a 65,000 dalton ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Bellini WJ,Silver GD,McFarlin DE

    更新日期:1983-01-01 00:00:00

  • Pathogenicity and phylogenetic evaluation of the variant Newcastle disease viruses termed "pigeon PMV-1 viruses" based on the nucleotide sequence of the fusion protein gene.

    abstract::The nucleotide sequences of the entire F genes of two isolates of the pigeon PMV-1 (PPMV-1) variant of Newcastle disease virus (NDV) were determined using RTPCR. The deduced amino acid sequences of the F0 protein showed four differences between isolate 760/83 which had been passaged 4 times in chickens and gave an int...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Collins MS,Strong I,Alexander DJ

    更新日期:1996-01-01 00:00:00

  • Expression and characterization of HPV-16 L1 capsid protein in Pichia pastoris.

    abstract::Human papillomaviruses (HPVs) are responsible for the most common human sexually transmitted viral infections. Infection with high-risk HPVs, particularly HPV16, is associated with the development of cervical cancer. The papillomavirus L1 major capsid protein, the basis of the currently marketed vaccines, self-assembl...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Bazan SB,de Alencar Muniz Chaves A,Aires KA,Cianciarullo AM,Garcea RL,Ho PL

    更新日期:2009-01-01 00:00:00

  • Electron microscopic observations on Aedes albopictus cells infected with dengue viruses.

    abstract::In dengue virus infected Aedes albopictus cells, electron-dense particles, larger than single ribosomes, were arranged on the cytoplasmic sides of rough endoplasmic reticulum (RER) membranes. Mature virions 40--45 nm in diameter as well as vesiculotubular structures 50--120 nm in diameter appeared in enlarged cisterna...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ko KK,Igarashi A,Fukai K

    更新日期:1979-01-01 00:00:00

  • Codiaeum variegatum in Pakistan harbours pedilanthus leaf curl virus and papaya leaf curl virus as well as a newly identified betasatellite.

    abstract::Codiaeum variegatum (common name, garden croton) is an ornamental plant grown for its bright yellow variegated leaf morphology. Two C. variegatum plants with upward leaf curling and vein swelling symptoms were collected in Faisalabad, Pakistan. Sequencing of clones obtained by PCR amplification with specific primers s...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Akram A,Khan AH,Rasool G,Mansoor S,Moffett P,Briddon RW,Saeed M

    更新日期:2020-08-01 00:00:00

  • Molecular epidemiological investigation of Marek's disease virus from Guangxi, China.

    abstract::The predominant field strains of Marek's disease virus in Guangxi were clearly different from the vaccine strain CVI988/Rispens based on sequencing of the envelope glycoprotein I (gI), glycoprotein E (gE) and oncogenic meq genes. These differences may be partly responsible for the most recent outbreaks in Guangxi. ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Teng LQ,Wei P,Song ZB,He JJ,Cui ZZ

    更新日期:2011-02-01 00:00:00

  • Inactivation and morphological changes of avian influenza virus by copper ions.

    abstract::The infectivity of the H9N2 virus to MDCK cells was time-dependently inhibited by Cu(2+) at concentrations of 2.5-250 microM. In 25 microM Cu(2+) solution, the virus titer decreased by approximately 3 and 4 log within 3 and 6 h, respectively. Compared to Cu(2+), Zn(2+) was much less effective in virus inactivation. Th...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Horie M,Ogawa H,Yoshida Y,Yamada K,Hara A,Ozawa K,Matsuda S,Mizota C,Tani M,Yamamoto Y,Yamada M,Nakamura K,Imai K

    更新日期:2008-01-01 00:00:00

  • Latent infection of human ovarian teratocarcinoma cells with human cytomegalovirus. Brief report.

    abstract::Persistent infection with human cytomegalovirus (HCMV) can be established in cultures of human ovarian teratocarcinoma (PA1) cells, and maintained for more than 200 days. Infected cultures maintained at 34 degrees C (PA1CMV34) and 37 degrees C (PA1CMV37) entered crisis and subsequently displayed massive cytopathic eff...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Kamiya S,Tanaka J,Ogura T,Sato H,Ogura H,Nakamura S,Hatano M

    更新日期:1986-01-01 00:00:00

  • Bovine herpesvirus type 1 gp87 mediates both attachment of virions to susceptible cells and hemagglutination.

    abstract::The 87,000-dalton glycoprotein (gp87) of bovine herpesvirus type 1 (BHV-1) was found to selectively attach to susceptible cells. The attachment of gp87 to the cells was markedly decreased by the prior adsorption of intact virions. Anti-gp87 (site Ia) monoclonal antibody, which inhibited BHV-1 adsorption to the cells a...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Okazaki K,Honda E,Minetoma T,Kumagai T

    更新日期:1987-01-01 00:00:00

  • Detection of human bocavirus-2 in children with acute gastroenteritis in South Korea.

    abstract::Human bocavirus (HBoV)-2, a new parvovirus, has been identified in stool samples and is suggested to be one of the etiologic agents of acute gastroenteritis (GE). The purpose of this study was to investigate the prevalence of HBoV-2 in children with GE. Stool samples were collected from 358 children hospitalized with ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Han TH,Kim CH,Park SH,Kim EJ,Chung JY,Hwang ES

    更新日期:2009-01-01 00:00:00

  • Isolation and characterization of a novel filamentous phage from Stenotrophomonas maltophilia.

    abstract::In this study, a novel filamentous phage, φSHP1, of the environmental Stenotrophomonas maltophilia strain P2 was isolated and characterized. Electron microscopy showed that φSHP1 resembled members of the family Inoviridae and was about 2.1 μm long. The 6,867-nucleotide genome of φSHP1 was a circular single-stranded DN...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Liu J,Liu Q,Shen P,Huang YP

    更新日期:2012-09-01 00:00:00

  • Influenza virus hemagglutinin stimulates the protein kinase C activity of human polymorphonuclear leucocytes.

    abstract::Human polymorphonuclear leukocytes (PMNL) incubated with influenza virus, A/USSR/90/77 (H1N1) or its hemagglutinin produced a significant increase in their PKC activity when compared with untreated PMNL. The activated kinase translocated from cytosol to cellular membrane. The calcium-dependent enzyme activity was inhi...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Arora DJ,Gasse N

    更新日期:1998-01-01 00:00:00

  • The complete genome sequence of an El Amar isolate of plum pox virus (PPV) and its phylogenetic relationship to other PPV strains.

    abstract::The genomic sequence of an El Amar isolate of plum pox virus (PPV) from Egypt was determined by sequencing overlapping cDNA fragments. This is the first complete sequence of a member of the El Amar (EA) strain of PPV. The genome consists of 9791 nt, excluding a poly(A) tail at the 3' terminus. The complete nt sequence...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Myrta A,Varga A,James D

    更新日期:2006-06-01 00:00:00