Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus.

Abstract:

:The mechanism of cell death induced by feline immunodeficiency virus (FIV) infection was investigated in an interleukin 2(IL-2)-dependent T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the cytopathic effect (CPE) observed in these cells was due to apoptosis. Infection of MYA-1 cells with FIV was associated with suppression of the proliferative response of the cells to exogenous IL-2 prior to DNA fragmentation. These findings suggest that FIV-induced CPE in these T-lymphoblastoid cells is associated with apoptosis possibly due to a defect in the IL-2 signal transduction pathway.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Ohno K,Okamoto Y,Miyazawa T,Mikami T,Watari T,Goitsuka R,Tsujimoto H,Hasegawa A

doi

10.1007/BF01309772

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

153-8

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

135

pub_type

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