Abstract：
:Since late 2018, foot-and-mouth disease (FMD) has reemerged and rapidly swept through pig farms in North and Central Vietnam, despite widespread use of commercial FMD vaccines. To investigate the FMD virus (FMDV) strains responsible for the current epidemics, 40 FMDV samples were collected from 17 provinces during November-December 2018, and the VP1 coding genes were sequenced and analyzed. Phylogenetic analysis and sequence comparisons revealed that all of the reemerging Vietnamese FMDVs belonged to the Mya-98 lineage of the O/Southeast Asia topotype (O/SEA/Mya-98) and shared high nucleotide (99.06-100% identity) and amino acid (97.65-100% identity) sequence similarity with each other. The study results suggested that the reemerging FMDVs originated from local Vietnamese strains. Field viruses had different amino acids in the antigenic sites of VP1 when compared to the strains used in the vaccines. The present study provides an important basis for vaccine selection in the battle against FMD in Vietnam.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Van Diep N,Ngoc TTB,Hoa LQ,Nga BTT,Kang B,Oh J,Lan NT,Le VPdoi
10.1007/s00705-020-04763-8subject
Has Abstractpub_date
2020-11-01 00:00:00pages
2487-2493issue
11eissn
0304-8608issn
1432-8798pii
10.1007/s00705-020-04763-8journal_volume
165pub_type
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