Abstract:
:The addition of a small proportion (10%) of in vivo concanavalin-A (Con-A)-activated spleen cells to normal spleen cell cultures suppressed the primary immune response to sheep erythrocytes (SRBC) but had no effect on the thymus-independent primary immune response to 3,5-dinitro-4-hydroxy-phenacetyl-conjugated lipopolysaccharide. When Con-A-activated cells were added after 24 h, there was no suppression of the anti-SRBC response but rather an enhanced response when few cells were admixed. Con-A-activated cells did not influence activation of normal cells by polyclonal T- and B-cell activators. It is concluded that Con-A-induced suppressor cells do not act on B cells but rather on helper cells (T cells or macrophages) at a very early stage of the immune response to thymus-dependent antigens.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Ekstedt RD,Waterfield JD,Nespoli L,Möller Gdoi
10.1111/j.1365-3083.1977.tb00391.xsubject
Has Abstractpub_date
1977-01-01 00:00:00pages
247-53issue
3eissn
0300-9475issn
1365-3083journal_volume
6pub_type
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