当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Identification of transcripts of the T cell antigen receptor beta chain gene and major histocompatibility complex class II genes in antigen-presenting cloned BK-BI-2.6.C6 cells.

Identification of transcripts of the T cell antigen receptor beta chain gene and major histocompatibility complex class II genes in antigen-presenting cloned BK-BI-2.6.C6 cells.

Abstract：

:The cloned murine cell line BK-BI-2.6.C6 has previously been shown to exhibit T cell characteristics, to synthesize and express MHC class II molecules, and to present protein antigens to antigen-dependent T cell clones. As a more definitive proof of the T-cell nature of these cells, transcripts of the rearranged T cell antigen receptor (TcR) beta gene were assessed by Northern blot analysis. BK-BI-2.6.C6 cells constitutively transcribe mRNA for the light chain of TcR and express the disulphide-linked alpha, beta TcR heterodimer at the cell surface. In addition mRNA for the polymorphic MHC class II subunits A alpha and A beta as well as for the invariant gamma chain were detected. BK-BI-2.6.C6 T cells effectively stimulated bovine insulin-reactive T hybridoma cells to lymphokine production in the presence of this antigen. Since the antigen-presenting and the responding T cell populations are maintained in culture in the absence of feeder cells, contamination by conventional accessory cells is excluded. These data unequivocally demonstrate that cloned murine Ia-expressing T cells can act as antigen-presenting accessory cells.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Reske-Kunz AB,Rück G,Steinlein P,Reske K

doi

10.1111/j.1365-3083.1988.tb02327.x

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

107-12

issue

1

eissn

0300-9475

issn

1365-3083

journal_volume

27

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • Human immunodeficiency virus-associated thrombotic microangiopathies: clinical characteristics and outcome according to ADAMTS13 activity.

    abstract：:Human immunodeficiency virus (HIV) infection is a risk factor for thrombotic microangiopathy (TMA). We sought whether a severe deficiency in ADAMTS13, the enzyme specifically involved in the cleavage of von Willebrand factor, was associated with specific presenting features and outcome in HIV-associated TMA. In this p...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-3083.2008.02143.x

    authors： Malak S,Wolf M,Millot GA,Mariotte E,Veyradier A,Meynard JL,Korach JM,Malot S,Bussel A,Azoulay E,Boulanger E,Galicier L,Devaux E,Eschwège V,Gallien S,Adrie C,Schlemmer B,Rondeau E,Coppo P,Réseau d'Etude des Microangi

    更新日期：2008-09-01 00:00:00

  • Characterization of homologous anti-alpha-fetoprotein antibodies produced in rabbits.

    abstract：:The natural tolerance to alpha-fetoprotein (AFP) was broken in rabbits by immunizations with purified AFP from different species and homologous AFP chemically modified by haptenation. Some of the rabbits were boostered with rabbit AFP. The highest titers were obtained with human AFP, which shows a strong cross-reactio...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb00279.x

    authors： Pihko H

    更新日期：1976-01-01 00:00:00

  • Sensitivity to glucocorticoids of lymph node cells stimulated in vivo by oxazolone.

    abstract：:Sensitization of B10.A mice with oxazolone results in delayed-type hypersensitivity (DTH) and a two to three-fold increase in the weight of regional lymph nodes by the third day. Hydrocortisone treatment of the animals 3 days after sensitization suppresses the manifestation of DTH on the tenth day but not on the seven...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1978.tb00529.x

    authors： Venetianer A,Arányi P,Bösze ZS,Fachet J

    更新日期：1978-01-01 00:00:00

  • Characterization of a susceptibility locus for SLE, SLEB5, on chromosome 4p14-13.

    abstract：:Systemic lupus erythematosus is a systemic autoimmune disorder of unknown aetiology but is most likely caused by an interaction between several genetic factors and the environment. In a previously published genome scan we presented linkage to a marker on chromosome 4p13 in Icelandic families. Fine mapping of the regio...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2006.01810.x

    authors： Johansson CM,Kristjánsdottir H,Gröndal G,Steinsson K,Alarcón-Riquelme ME

    更新日期：2006-09-01 00:00:00

  • CD8+CD60+ T cells, cells expressing epsilon specific mRNA and Th1/Th2 cytokines in cord blood and at 7 months of age.

    abstract：:IgE levels in cord blood have been investigated as predictors of atopy, but no definitive findings have been made. Other factors, including cells and/or cytokines may serve as predictors of this disease. Cord blood and peripheral blood was obtained at birth and at 7 months of age, respectively, from children (n = 2) w...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2008.02169.x

    authors： Smith-Norowitz TA,Norowitz KB,Silverberg JI,Chice S,Shah V,Stanek A,Walker D,Brennan JP,Durkin HG,Bluth MH

    更新日期：2008-11-01 00:00:00

  • Bacteriostatic activity of BCG/PPD-activated macrophages against Mycobacterium fortuitum does not involve reactive nitrogen or oxygen intermediates.

    abstract：:Mycobacteria preferentially reside in resident macrophages whereas activated macrophages are presumed to eliminate the bacteria effectively. The aim of the present study was to determine the antibacterial activities of resident and activated murine peritoneal macrophages against Mycobacterium fortuitum and the intrace...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1994.tb03449.x

    authors： Nibbering PH,Yoshida SI,van den Barselaar MT,van Furth R

    更新日期：1994-08-01 00:00:00

  • Separate but complementary roles for the two forms of interleukin 1 in the growth of transformed human B lymphoblasts.

    abstract：:Epstein-Barr virus (EBV)-transformed human B cells were seeded at densities below their capacity for autostimulatory growth and the effects of interleukin 1-alpha (IL-1-alpha), interleukin 1-beta (IL-1-beta) and B-cell growth factor (BCGF) were studied. When added separately, IL-1-alpha was able to support the growth ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1987.tb02263.x

    authors： Gallagher G,Taylor N,Willdridge J

    更新日期：1987-09-01 00:00:00

  • Stimulation by T cell independent antigens can relieve the arrest of differentiation of immature auto-reactive B cells in the bone marrow.

    abstract：:The pair of microH-chain and kappa L-chain transgenes encoding the Sp6 TNP/DNA-specific IgM was bred onto the rearrangement-deficient genetic background of RAG-2T mice, and onto the kappa L-chain expression-deficient background of iE kappa T mice. Bone marrow of Sp6 transgenic RAG-2T mice contained normal numbers of B...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1995.tb03621.x

    authors： Andersson J,Melchers F,Rolink A

    更新日期：1995-07-01 00:00:00

  • Immunological characterization of novel secreted antigens of Mycobacterium tuberculosis.

    abstract：:Proteins secreted by Mycobacterium tuberculosis are targets of host immune responses and as such are investigated for vaccine and immunodiagnostics development. Computer-driven searches of the M. tuberculosis H37Rv genome had previously identified 45 novel secreted proteins. Here, we report the characterization of the...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2005.01557.x

    authors： Ben Amor Y,Shashkina E,Johnson S,Bifani PJ,Kurepina N,Kreiswirth B,Bhattacharya S,Spencer J,Rendon A,Catanzaro A,Gennaro ML

    更新日期：2005-02-01 00:00:00

  • T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients.

    abstract：:The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1992.tb03128.x

    authors： Gudmundsson S,Rönnelid J,Karlsson-Parra A,Lysholm J,Gudbjörnsson B,Widenfalk B,Janson CH,Klareskog L

    更新日期：1992-11-01 00:00:00

  • Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels.

    abstract：:The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primar...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2004.01409.x

    authors： Carvalho LJ,Oliveira SG,Theisen M,Alves FA,Andrade MC,Zanini GM,Brígido MC,Oeuvray C,Póvoa MM,Muniz JA,Druilhe P,Daniel-Ribeiro CT

    更新日期：2004-04-01 00:00:00

  • Thalidomide prolongs experimental autoimmune neuritis in Lewis rats.

    abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00421.x

    authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

    更新日期：1998-10-01 00:00:00

  • Quantitation of cells secreting immunoglobulins after elution from rheumatoid synovial tissue.

    abstract：:Mononuclear cells (MNC) eluted from rheumatoid synovial tissue of 16 patients with rheumatoid arthritis were examined for immunoglobulin-secreting cells (ISC). Immediately after elution and separation synovial tissue MNC contained considerable numbers of ISC. IgG and IgA ISC were more abundant than IgM ISC. At the sam...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1982.tb00741.x

    authors： Egeland T,Lea T,Mellbye OJ,Pahle JA,Ottesen T,Natvig JB

    更新日期：1982-11-01 00:00:00

  • Soluble CD4: a link between specific immune mechanisms and non-specific inflammatory responses?

    abstract：:The CD4 molecule is an important cell surface molecule expressed on many cell types including T-helper cells. CD4 can be shed from cells, and the truncated soluble form of CD4 (sCD4) has been found elevated in serum in several diseases. In this study the authors show that migration of polymorphonuclear neutrophils (PM...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1996.d01-264.x

    authors： Goto H,Gidlund M

    更新日期：1996-06-01 00:00:00

  • Human anti-F(ab')2 antibodies and pepsin agglutinators react with Fv determinants.

    abstract：:Affinity-purified human IgG anti-tetanus antibody was subjected to papain and then pepsin digestion, and residual fragments retaining antibody activity were re-isolated by adsorption and elution from Sepharose-tetanus toxoid columns. Both Fab' and Fv fragments isolated by gel filtration showed strong reactivity with a...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb03082.x

    authors： Silvestris F,Williams RC Jr,Searles RP

    更新日期：1986-04-01 00:00:00

  • CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression.

    abstract：:CD25 monoclonal antibody binding to the alpha-chain of the Interleukin-2 (IL-2) receptor, blocks high-affinity IL-2 binding, thereby preventing complete T-cell activation and being of ample importance in transplantation medicine and potentially the treatment of autoimmune disease. However, CD25 antibodies do not only ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2009.02281.x

    authors： Richter GH,Mollweide A,Hanewinkel K,Zobywalski C,Burdach S

    更新日期：2009-09-01 00:00:00

  • T-cell stimulation induced by idiotypes on monoclonal immunoglobulins in patients with monoclonal gammopathies.

    abstract：:The stimulation of peripheral blood mononuclear cells by purified autologous and/or allogeneic monoclonal IgG was studied in five patients with multiple myeloma (MM), nine patients with monoclonal gammopathy of undetermined significance (MGUS) and six healthy individuals. Single cells secreting IFN-gamma or IL-2 were ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1993.tb03236.x

    authors： Yi Q,Bergenbrant S,Osterborg A,Osby E,Ostman R,Björkholm M,Holm G,Lefvert AK

    更新日期：1993-12-01 00:00:00

  • Target cell lysis by natural killer cells is influenced by beta 2-microglobulin expression.

    abstract：:Natural killer (NK) cells form part of the vertebrate defence against viruses and tumours, but show only limited specificity. The molecule(s) recognized by NK cells on target cells are at present unknown. Major histocompatibility complex (MHC) class I antigen concentration on target cells is inversely correlated with ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01184.x

    authors： Müllbacher A,King NJ

    更新日期：1989-07-01 00:00:00

  • NcoI restriction fragment length polymorphism (RFLP) of the tumour necrosis factor (TNF alpha) region in primary biliary cirrhosis and in healthy Danes.

    abstract：:The restriction fragment length polymorphism of the human tumour necrosis factor (TNF alpha) region was investigated by means of 20 different restriction enzymes and a human TNF alpha cDNA probe. Only one of the enzymes, NcoI, revealed a polymorphic pattern consisting of fragments of 10.5 and 5.5 kb, which behaved as ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01200.x

    authors： Fugger L,Morling N,Ryder LP,Platz P,Georgsen J,Jakobsen BK,Svejgaard A,Dalhoff K,Ranek L

    更新日期：1989-08-01 00:00:00

  • Early HIV infection is associated with reduced proportions of gamma delta T subsets as well as high creatinine and urea levels.

    abstract：:Renal dysfunctions are major predictors of co-morbidities and mortality in HIV-infected individuals. Unconventional T cells have been shown to regulate kidney functions. However, there is dearth of information on the effect of HIV-associated nephropathies on γδ and DN T cells. It is also not clear whether γδ T cell pe...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12868

    authors： Olusola BA,Kabelitz D,Olaleye DO,Odaibo GN

    更新日期：2020-05-01 00:00:00

  • Human membrane-bound C3 receptors. I. Serological and immunohistological demonstration of C3 receptors.

    abstract：:The aim of the present study was to present further evidence of the specific reactivity of an anti-C3 receptor serum (AC3RS), to demonstrate membrane-bound C3 receptors by using this AC3RS in different serological an immunohistological methods, and to investigate the relationship between membrane-bound C3 receptors an...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1981.tb00112.x

    authors： Stein H,Gerdes J,Tolksdorf G,Klatt U

    更新日期：1981-01-01 00:00:00

  • Galectin-3 is associated with severe heart failure and death: A hospital-based study in Chinese patients.

    abstract：:Heart failure (HF) is a serious disease syndrome characterized by elevated pro-inflammatory cytokines and inflammatory mediators presume to have significant contribution on disease progression. Galectins are carbohydrate-binding proteins responsible of various physiological functions. Role of galectins in heart failur...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12826

    authors： Wang N,Dang M,Zhang W,Lei Y,Liu Z

    更新日期：2020-05-01 00:00:00

  • PHA-induced activation of suppressor cells in normal human peripheral blood lymphocytes.

    abstract：:Normal human peripheral blood and tonsil lymphocytes can be stimulated to proliferate by phytohemagglutinin (PHA). When cells cultured with this mitogen for 3 days were transferred fo fresh autologous lymphocytes in fresh medium with PHA, the mitogen response of the fresh lymphocytes was suppressed. The suppression re...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb03026.x

    authors： Kurnick JT,Bell C,Grey HM

    更新日期：1976-01-01 00:00:00

  • Reduced apoptosis of mouse macrophages induced by yscW mutant of Yersinia pestis results from the reduced secretion of YopJ and relates to caspase-3 signal pathway.

    abstract：:The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III secretion system (T3SS) that injects six Yersinia outer protein (Yop) effector proteins into the cytosol of macrophages, leading to disruption of host defence mechanisms. Here, we report that a T3SS structural protein YscW of Yersin...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2009.02297.x

    authors： Bi Y,Du Z,Yang H,Guo Z,Tan Y,Zhu Z,Yang R

    更新日期：2009-10-01 00:00:00

  • The fifth serum amyloid A-related gene sequence, GSAA4, is SAA3.

    abstract：:The human serum amyloid A (SAA) gene family consists of two acute phase genes, SAA1 and SAA2; a pseudogene, SAA3 and a fourth gene, SAA4. The existence of SAA4 was first described in this laboratory. Subsequently, Sack & Talbot isolated a clone, designated GSAA4, which had homology to SAA3. The clone was described as ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1994.tb03460.x

    authors： Watson G,Faulkes DJ,Woo P

    更新日期：1994-08-01 00:00:00

  • The effects of thymopentin on the development of SLE-like syndrome in the MRL/lpr-lpr mouse.

    abstract：:Thymopentin (TP-5) is a synthetic pentapeptide that corresponds to the active 32-36 amino acid sequence of the thymic hormone thymopoietin, of which it retains all the immunomodulatory properties. In this study, we have evaluated the effects of long term prophylactic treatment with TP-5 on the clinical, immunological ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1994.tb03503.x

    authors： Nicoletti F,Zaccone P,Magro G,Barcellini W,Cavallaro V,Belli G,Cocuzza C,di Marco R,Meroni PL

    更新日期：1994-11-01 00:00:00

  • Long-distance running modulates the expression of leucocyte and endothelial adhesion molecules.

    abstract：:There still exist many unanswered questions whether physical exercise is beneficial or harmful to the immune system. The 'open-window' post-exercise hypothesis states that athletes are more susceptible to infections after exercise, but there is a need for further elucidation. The aim of the present study was to invest...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2004.01486.x

    authors： Nielsen HG,Lyberg T

    更新日期：2004-10-01 00:00:00

  • Irregular cytokine pattern of CD4+ T lymphocytes in response to Staphylococcus aureus in patients with Wegener's granulomatosis.

    abstract：:The initial stage of Wegener's Granulomatosis (WG) is often marked by symptoms of infection and it has been postulated that a bacterial infection could be the aetiologic factor of this disease. The objective of our work was to investigate T-cell-mediated immunity in WG by testing proliferative responses on bacterial a...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1999.00544.x

    authors： Mayet WJ,Märker-Hermann E,Schlaak J,Meyer Zum Büschenfelde KH

    更新日期：1999-06-01 00:00:00

  • Study of the mechanism for in vitro activation of mouse NK cells by interferon.

    abstract：:The enhancement of the lytic capacity of mouse splenic 'natural killer' (NK) cells by interferon has been studied in vitro as a model for NK cell differentiation from inactive immediate precursors. We show that the increased cytotoxicity is a function of interferon concentration, and that two stages in the NK cell dif...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1980.tb00040.x

    authors： Senik A,Kolb JP,Orn A,Gidlund M

    更新日期：1980-01-01 00:00:00

  • The role of surface ig binding in the activation of human B cells by phosphorothioate oligodeoxynucleotides.

    abstract：:Phosphorothioate oligodeoxynucleotides (sODNs) can induce T-cell-independent polyclonal activation of human B cells by a mechanism that depends on both sequence and back-bone structure. Because matrix-bound as well as soluble sODNs are mitogenic, this stimulation may result from the engagement of surface receptor(s). ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2001.01004.x

    authors： Liang H,Reich CF,Pisetsky DS,Lipsky PE

    更新日期：2001-12-01 00:00:00