Early HIV infection is associated with reduced proportions of gamma delta T subsets as well as high creatinine and urea levels.


:Renal dysfunctions are major predictors of co-morbidities and mortality in HIV-infected individuals. Unconventional T cells have been shown to regulate kidney functions. However, there is dearth of information on the effect of HIV-associated nephropathies on γδ and DN T cells. It is also not clear whether γδ T cell perturbations observed during the early stages of HIV infection occur before immune activation. In this study, we investigated the relationship between creatinine and urea on the number of unconventional T cells in HIV-infected individuals at the early and chronic stages of infection. Persons in the chronic stage of infection were divided into treatment naïve and exposed groups. Treatment exposed individuals were further subdivided into groups with undetectable and detectable HIV-1RNA in their blood. Creatinine and urea levels were significantly higher among persons in the early HIV infection compared with the other groups. Proportions of γδ T, γδ + CD8, γδ + CD16 cells were also significantly reduced in the early stage of HIV infection (P < .01). Markers of immune activation, CD4 + HLA-DR and CD8 + HLA-DR, were also significantly reduced during early HIV infection (P < .01). Taken together, our findings suggest that high levels of renal markers as well as reduced proportions of gamma delta T cells are associated with the early stages of HIV infection. This event likely occurs before systemic immune activation reaches peak levels. This study provides evidence for the need for early HIV infection diagnosis and treatment.


Scand J Immunol


Olusola BA,Kabelitz D,Olaleye DO,Odaibo GN




Has Abstract


2020-05-01 00:00:00












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    abstract::Pretreatment with D-Penicillamine of rat peritoneal macrophages markedly influences their ability to modulate Concanavalin A stimulated [3H]thymidine incorporation in non-adherent rat lymph node cells. Untreated macrophages added in high numbers to the lymphocytes (ratio lymphocytes/macrophage 7.5 : 1) depress their [...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Binderup L,Bramm E,Arrigoni-Martelli E

    更新日期:1978-04-01 00:00:00

  • Long-distance running modulates the expression of leucocyte and endothelial adhesion molecules.

    abstract::There still exist many unanswered questions whether physical exercise is beneficial or harmful to the immune system. The 'open-window' post-exercise hypothesis states that athletes are more susceptible to infections after exercise, but there is a need for further elucidation. The aim of the present study was to invest...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Nielsen HG,Lyberg T

    更新日期:2004-10-01 00:00:00

  • PHA-induced activation of suppressor cells in normal human peripheral blood lymphocytes.

    abstract::Normal human peripheral blood and tonsil lymphocytes can be stimulated to proliferate by phytohemagglutinin (PHA). When cells cultured with this mitogen for 3 days were transferred fo fresh autologous lymphocytes in fresh medium with PHA, the mitogen response of the fresh lymphocytes was suppressed. The suppression re...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kurnick JT,Bell C,Grey HM

    更新日期:1976-01-01 00:00:00

  • Identity of HML-1 antigen on intestinal intraepithelial T cells and of B-ly7 antigen on hairy cell leukaemia.

    abstract::Immunoprecipitation of radioiodinated hairy cell leukaemia (HCL) cell lysates with monoclonal antibody (MoAb) HML-1, originally reported to recognize intraepithelial T cells, and with MoAb B-ly7, originally reported to react with HCL, led to identical biochemical characteristics. In SDS-PAGE under reducing conditions,...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Moldenhauer G,Mielke B,Dörken B,Schwartz-Albiez R,Möller P

    更新日期:1990-08-01 00:00:00

  • Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis.

    abstract::The major rheumatoid factor cross-reactive idiotype, which was defined by prototypic monoclonal IgM rheumatoid factors from Waldenstrom's macroglobulinaemia patient Wa, is present on 60% of all monoclonal IgM RF paraproteins. One-third of patients with juvenile rheumatoid arthritis (JRA), who are seronegative for clas...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Ilowite NT,Wedgwood JF,Moore TL,Ramakrishnan T,Bonagura VR

    更新日期:1991-10-01 00:00:00

  • Membrane expression and function of complement receptors CR1 and CR3 on neutrophils from HIV-infected subjects: modulation by rTNF-alpha and rGM-CSF.

    abstract::We evaluated membrane expression and function of complement receptors CR1 and CR3 on neutrophils from 27 HIV-positive (HIV+) subjects (14 in the CDC class III and 13 class IV) as well as their modulation in vitro by recombinant tumour necrosis factor-alpha (rTNF-alpha) and granulocyte-macrophage colony stimulating fac...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Capsoni F,Minonzio F,Colombo G,Ongari AM,Bonara P,Rizzardi GP,Lazzarin A,Zanussi C

    更新日期:1992-10-01 00:00:00

  • Lack of polarized type 1 or type 2 cytokine profile in asymptomatic HIV-1-infected patients during a two-year bimonthly follow-up.

    abstract::The production of type 1 (interferon or IFN-gamma) and type 2 (interleukin or IL-4 and IL-10) cytokines by mitogen-stimulated peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic human immunodeficiency virus-seropositive (HIV+) patients untreated with any antiviral, antibacterial or antimycotic drugs,...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Canaris AD,Caruso A,Licenziati S,Cantalamessa A,De Francesco MA,Fallacara F,Fiorentini S,Dima F,Martinelli F,Manca N,Balsari A,Turano A

    更新日期:1998-02-01 00:00:00

  • Human peripheral blood null lymphocytes stimulated by Staphylococcus aureus Cowan I produce atypical acid-labile interferon in vitro.

    abstract::Peripheral blood mononuclear leucocytes (PBLs) stimulated in vitro by heat-killed formaldehyde-fixed Staphylococcus aureus Cowan I (SACoI) produced acid-labile alpha interferon (IFN-alpha) and, to various extents, also IFN-gamma. The IFN producers resided in nylon wool-nonadherent cells, and monocytes suppressed SACoI...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Funa K,Ramstedt U,Rönnblom L,Alm GV

    更新日期:1985-01-01 00:00:00

  • Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Carballo I,Rabuñal N,Alvela L,Pérez LF,Vidal C,Alonso M,Sopeña B,Gude F,Gonzalez-Quintela A

    更新日期:2017-04-01 00:00:00

  • CTL-based cancer preventive/therapeutic vaccines for carcinomas: role of tumour-associated carbohydrate antigens.

    abstract::In this study, we discuss the use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as preventive vaccines for carcinomas. The results of our recent studies suggest that CD8(+) cytotoxic T cells are capable of recognizing small TACA in a conventional class I MHC-restricted fashion. TACA-specif...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Franco A

    更新日期:2005-05-01 00:00:00

  • Role of dendritic cells in Sjögren's syndrome.

    abstract::Sjögren's syndrome (SS) is a chronic inflammatory and lymphoproliferative autoimmune disease of unknown aetiology. It is characterised by progressive mononuclear cell infiltration of the salivary and lacrimal glands and a decreased glandular secretion, resulting in dryness of the mouth and eyes (xerostomia and keratoc...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Vogelsang P,Jonsson MV,Dalvin ST,Appel S

    更新日期:2006-09-01 00:00:00

  • The influence of serum on lymphocyte cultures. II. Cell cycle specificity of serum action in spleen cells.

    abstract::Serum exerts several effects in lymphocyte cultures, one of them being manifested very early. The presence of fetal calf serum (FCS) results in a markedly higher thymidine uptake within a few minutes, as compared with serum-free cultures. On the other hand, the uptake of uridine and other purine bases seem to be littl...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kristensen F,Joncourt F,de Weck AL

    更新日期:1981-08-01 00:00:00

  • Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity.

    abstract::Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin-3 in patients with newly diagnosed RA and associations with disease profile, Magnetic resonance imaging (MRI) findings and seromarkers of synovial matrix inflamm...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Issa SF,Christensen AF,Lindegaard HM,Hetland ML,Hørslev-Petersen K,Stengaard-Pedersen K,Ejbjerg BJ,Lottenburger T,Ellingsen T,Pedersen JK,Junker K,Svendsen A,Tarp U,Østergaard M,Junker P

    更新日期:2017-12-01 00:00:00

  • Proliferative kinetics, phenotype and cytotoxic function of thymic and peripheral T-cell colonies.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Röpke C,Claësson MH

    更新日期:1986-02-01 00:00:00

  • Use of the V delta 1 variable region in the functional T-cell receptor alpha chain of a WT31+ cytotoxic T lymphocyte clone which specifically recognizes HLA-A2 molecule.

    abstract::We report here the molecular characterization of the T-cell receptor (TCR) expressed by a human HLA-A2 specific cytotoxic T-cell clone named CTL 49. Flow cytometry analysis with a panel of anti-TCR antibodies revealed an OKT3+, WT31+, A13+, BB3-, TCR delta-, delta TCS1-, TCR gamma/delta 1-, OKT4-, and OKT8+ phenotype,...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Castelli C,Mazzocchi A,Salvi S,Anichini A,Sensi M

    更新日期:1992-04-01 00:00:00

  • The formyl peptide N-formyl-methionyl-leucyl-phenylalanine downregulates the expression of FcgammaRs in interferon-gamma-activated monocytes/macrophages in vitro and in vivo.

    abstract::N-Formyl peptides are cleavage products of bacterial and mitochondrial proteins that have pro-inflammatory activities and play an important role in antibacterial host defence. FcgammaRI is a receptor for the Fc portion of immunoglobulin G expressed in monocytes that mediates cytotoxicity and is upregulated by interfer...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Beigier-Bompadre M,Barrionuevo P,Alves-Rosa F,Rubel CJ,Palermo MS,Isturiz MA

    更新日期:2003-03-01 00:00:00

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    abstract::To examine the possible relationship between the cells mediating resistance to tumour cells and those mediating rejection of foreign bone marrow transplants (BMT), the effect of tumour-bearing on BMT rejection has been measured by means of the spleen colony assay. Moderate doses (less than 5.0 X 10(6] of bone marrow c...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Miller SC,Nguyen D,Bird IA

    更新日期:1988-04-01 00:00:00

  • IL-23 Activated γδ T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL-21 in Children with Primary Nephrotic Syndrome.

    abstract::This study (1) analysed the percentage of γδ T cells, γδ T cell subsets, Th17 cells and regulatory T cells (Treg cells) and (2) determined the role of IL-23 in primary nephrotic syndrome (PNS) patients with active disease and in remission. Eighty-four patients with PNS and 51 healthy age-matched controls were included...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Zhang L,Yan J,Yang B,Zhang G,Wang M,Dong S,Liu W,Yang H,Li Q

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Løvik G,Vaage JT,Rolstad B,Naper C

    更新日期:2001-10-01 00:00:00

  • Evidence for a type 1 diabetes susceptibility locus (IDDM10) on chromosome 10p11-q11 in a Russian population.

    abstract::Around 20 susceptibility loci for type 1 diabetes mellitus (T1DM) have been mapped. One of these loci, IDDM10, was found on chromosome 10p11-q11. Here, we investigated whether the IDDM10 locus contributes in the susceptibility to T1DM in a Russian family dataset. One hundred and fourteen simplex Russian families, each...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Chistiakov DA,Seryogin Y,Savost'anov KV,Zilberman LI,Titovich EV,Kuraeva TL,Dedov II,Nosikov VV

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  • Alpha 1-microglobulin is mitogenic for guinea pig lymphocytes.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lögdberg L,Akerström B,Shevach EM

    更新日期:1986-11-01 00:00:00

  • V and C gene contribution in creating anti-alpha-1,3 dextran antibodies in mice. II. Characteristics of Ig-lb to e prototype responses.

    abstract::The light (L) and heavy (H) chain and the idiotypic (Id) composition of the antibody (Ab) plaque-forming cells (PFC) and serum Ab specific for alpha-1,3 dextran have been characterized in murine strains exhibiting the CH-Ig-lb to e allotypes and in their F1 hybrids with Ig-la1, BALB/c prototypes. The Ab response of th...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Bell C

    更新日期:1979-03-01 00:00:00

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    abstract::Antigen-specific lymphocyte hybridomas have been produced by a simple in vitro immunization procedure. Non-immune spleen cells have been activated in vitro, and the B-cell blasts have subsequently been used for somatic cell hybridization. Hybrids secreting monoclonal antibodies to human myoglobin, pig insulin, and ben...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Borrebaeck CA

    更新日期:1983-07-01 00:00:00

  • The complex of alpha 2-macroglobulin with CD2 in the plasma of gastric carcinoma patients.

    abstract::alpha 2-macroglobulin (alpha 2M) preparations purified from the plasma of healthy persons and gastric carcinoma patients were further analysed by immunochemical techniques. It was found that only alpha 2M from the plasma of gastric carcinoma patients gave a positive reaction with E-receptor sheep antiserum in rocket i...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Smorodin EP,Kurtenkoy OA

    更新日期:1991-06-01 00:00:00

  • B-cell CD25 expression in murine primary and secondary lymphoid tissue.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Amu S,Gjertsson I,Tarkowski A,Brisslert M

    更新日期:2006-11-01 00:00:00

  • Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases.

    abstract::BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell development, with loss-of-function mutations causing X-linked agammaglobulinemia and susceptibility to severe, frequently lethal, Epstein-Barr virus infection, respectively. Over the last few years, considerable efforts have been made ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Vargas L,Hamasy A,Nore BF,Smith CI

    更新日期:2013-08-01 00:00:00

  • The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity.

    abstract::The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated wit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Cardona PJ,Cooper A,Luquín M,Ariza A,Filipo F,Orme IM,Ausina V

    更新日期:1999-04-01 00:00:00

  • The architecture of rat lymph nodes. IV. Distribution of ferritin and colloidal carbon in the draining lymph nodes after foot-pad injection.

    abstract::Rat popliteal and the iliac lymph nodes were examined after foot-pad injections of colloidal carbon and ferritin-tetramethylrhodamine isothiocyanate. Carbon rapidly entered medullary sinuses, but the entry of carbon into the interstitium was prohibited by avid phagocytosis, by sinus macrophages and by the lymphoendoth...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Fossum S

    更新日期:1980-01-01 00:00:00

  • Complement activation and interleukin response in major abdominal surgery.

    abstract::The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. The study design was prospective and randomised. Fifty patients undergoin...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,随机对照试验


    authors: Kvarnström AL,Sarbinowski RT,Bengtson JP,Jacobsson LM,Bengtsson AL

    更新日期:2012-05-01 00:00:00

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    abstract::Histamine release from normal human leukocytes can be induced by anti-IgE or protein A from Staphylococcus aureus. After incubation in buffer at 37 degrees C for various time intervals or repeated washings with buffer, or both procedures, the leukocytes lose most of their reactivity to protein A, whereas the reactivit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Petersson BA

    更新日期:1975-01-01 00:00:00