Early HIV infection is associated with reduced proportions of gamma delta T subsets as well as high creatinine and urea levels.


:Renal dysfunctions are major predictors of co-morbidities and mortality in HIV-infected individuals. Unconventional T cells have been shown to regulate kidney functions. However, there is dearth of information on the effect of HIV-associated nephropathies on γδ and DN T cells. It is also not clear whether γδ T cell perturbations observed during the early stages of HIV infection occur before immune activation. In this study, we investigated the relationship between creatinine and urea on the number of unconventional T cells in HIV-infected individuals at the early and chronic stages of infection. Persons in the chronic stage of infection were divided into treatment naïve and exposed groups. Treatment exposed individuals were further subdivided into groups with undetectable and detectable HIV-1RNA in their blood. Creatinine and urea levels were significantly higher among persons in the early HIV infection compared with the other groups. Proportions of γδ T, γδ + CD8, γδ + CD16 cells were also significantly reduced in the early stage of HIV infection (P < .01). Markers of immune activation, CD4 + HLA-DR and CD8 + HLA-DR, were also significantly reduced during early HIV infection (P < .01). Taken together, our findings suggest that high levels of renal markers as well as reduced proportions of gamma delta T cells are associated with the early stages of HIV infection. This event likely occurs before systemic immune activation reaches peak levels. This study provides evidence for the need for early HIV infection diagnosis and treatment.


Scand J Immunol


Olusola BA,Kabelitz D,Olaleye DO,Odaibo GN




Has Abstract


2020-05-01 00:00:00












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    abstract::Human peripheral blood lymphocytes (PBL) were activated with K46M, a m mitogenic monoclonal antibody against La-reactive T lymphocyte surface structures. The cultures were expanded in the presence of interleukin 2 (IL-2). After 1 month of culture, the activated T cells were cloned by limiting dilution at 0.5 cells/wel...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Berzins T,Vargas-Cortes M,Axelsson B,Hammarström ML,Hammarström S,Perlmann P

    更新日期:1988-11-01 00:00:00

  • Specifically decreased MLC response of lymphocytes from CBA mice injected with cells from the H-2-compatible, M-antigen-incompatible strain C3H. Lack of such effect after injection of H-2-disparate C3H-hybrid cells.

    abstract::The mixed lymphocyte culture (MLC) response of lymphocytes from CBA mice against C3H cells was studied after injection of spleen cells from C3H mice or C3H hybrids. Intravenous infusion of C3H cells resulted in a strongly suppressed specific MLC response, but this was not the case when cells from H-2-incompatible hybr...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lilliehöök B,Jacobsson H,Blomgren H

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  • Prethymic progenitors from the avian para-aortic mesoderm express GATA-3 and distinct chTcf isoforms but still lack T-cell receptor-gamma rearrangements.

    abstract::Haematopoietic precursors first colonizing the avian embryonic thymus are derived from the intraembryonic sites located around the dorsal aortae. These intraembryonic precursors have previously been demonstrated to include cells that harbour T-cell progenitor capacity and express the Ikaros transcription factor, known...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Liippo J,Koskela K,Lassila O

    更新日期:2000-11-01 00:00:00

  • Human interleukin 2: production by both TG cells and other T cells.

    abstract::We have investigated the production of interleukin 2 (IL-2) by human T cells after their stimulation by phytohaemagglutinin (PHA). T cells isolated by rosetting with sheep erythrocytes produced high levels of IL-2. Further separation of rosette-forming cells, according to the expression of Fc receptors for IgG, showed...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Silva AG,Alvarez JM,Bonnard GD,de Landazuri MO

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  • Effects of G-CSF on telomere lengths in PBMCs from human immunodeficiency virus-infected patients: results from a randomized, placebo-controlled trial.

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    journal_title:Scandinavian journal of immunology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Aladdin H,Ullum H,Schjerling P,Skov Jensen M,Dam Nielsen S,Mathiesen L,Gerstoft J,Skinhøj P,Klarlund Pedersen B

    更新日期:2000-08-01 00:00:00

  • IL-23 Activated γδ T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL-21 in Children with Primary Nephrotic Syndrome.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Zhang L,Yan J,Yang B,Zhang G,Wang M,Dong S,Liu W,Yang H,Li Q

    更新日期:2018-01-01 00:00:00

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


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  • A novel antibody directed against a three-dimensional configuration of a 95-kDa protein in patients with autoimmune hepatic diseases.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Miyachi K,Matsushima H,Hankins RW,Hirakata M,Mimori T,Hosaka H,Amagasaki Y,Miyakawa H,Kako M,Shibata M,Onozuka Y,Ueno U

    更新日期:1998-01-01 00:00:00

  • A high frequency of cytotoxic precursor cells for a syngeneic tumour.

    abstract::The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tum...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Warren HS,Lafferty KJ

    更新日期:1979-01-01 00:00:00

  • Is it worthy to take full-course immunotherapy for allergic rhinitis? About efficacy biomarker of allergen immunotherapy.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,meta分析,评审


    authors: Wang W,Yin J

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Yamada M,Tamura N,Shirai T,Kira S

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  • The double role of the endoplasmic reticulum chaperone tapasin in peptide optimization of HLA class I molecules.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Cabrera CM

    更新日期:2007-06-01 00:00:00

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    abstract::F protein is of unknown function and found principally in the liver, with smaller amounts detectable by gel diffusion and immunostaining in kidney and brain. By taking advantage of a newly developed radioimmunoassay, capable of detecting down to 1 ng ml-1 of F protein, the organ distribution of this molecule in the mo...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Griffiths JA,Oliveira DB

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Ruud E,Beiske K,Drack A,Steen HB,Godal T

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kowal K,Moniuszko M,Dabrowska M,Bodzenta-Lukaszyk A

    更新日期:2012-05-01 00:00:00

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


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    更新日期:2000-07-01 00:00:00

  • Antidrug Antibodies: B Cell Immunity Against Therapy.

    abstract::Chronic inflammatory diseases are now treated with a range of different biopharmaceuticals, often requiring lifelong parenteral administrations. This exposure to drugs is unnatural and can trigger the immune system and result in the formation of antidrug antibodies. Drug-specific antibodies will, if of sufficiently hi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Fogdell-Hahn A

    更新日期:2015-09-01 00:00:00

  • Lymphocyte-endothelial interactions in inflamed synovia: involvement of several adhesion molecules and integrin epitopes.

    abstract::The role of several adhesion molecules for lymphocyte-endothelial interactions in the synovia of rheumatoid arthritis patients was studied using the frozen section assay. Partial inhibition of lymphocyte binding to endothelium of synovial sections could be observed with antibodies against CD44, L-selectin, and beta 1-...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


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    更新日期:1993-08-01 00:00:00

  • RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases.

    abstract::RNA silencing is an efficient biochemical tool for gene knock downs as well as physiological phenomenon playing a major role in diverse biological processes. Recent knowledge suggests that the same protein families which mediate the experimental RNA interference (RNAi) in the fruit fly Drosophila melanogaster cells al...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


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    更新日期:2010-03-01 00:00:00

  • The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.

    abstract::Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signalling in human NK cells involves Abl-1 (c-Abl)-mediated phosphorylation of Crk, lowering NK cell function ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Ganesan S,Luu TT,Chambers BJ,Meinke S,Brodin P,Vivier E,Wetzel DM,Koleske AJ,Kadri N,Höglund P

    更新日期:2017-09-01 00:00:00

  • Activated CD3- CD16+ natural killer cells express a subset of the lymphokine genes induced in activated alpha beta + and gamma delta + T cells.

    abstract::In this study we analysed the potential of highly purified polyclonal TcR alpha beta+, TcR gamma delta + and CD3- NK cells, to produce lymphokines in response to mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with le...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Biassoni R,Ferrini S,Prigione I,Pelak VS,Sekaly RP,Long EO

    更新日期:1991-03-01 00:00:00

  • Membrane expression and function of complement receptors CR1 and CR3 on neutrophils from HIV-infected subjects: modulation by rTNF-alpha and rGM-CSF.

    abstract::We evaluated membrane expression and function of complement receptors CR1 and CR3 on neutrophils from 27 HIV-positive (HIV+) subjects (14 in the CDC class III and 13 class IV) as well as their modulation in vitro by recombinant tumour necrosis factor-alpha (rTNF-alpha) and granulocyte-macrophage colony stimulating fac...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Capsoni F,Minonzio F,Colombo G,Ongari AM,Bonara P,Rizzardi GP,Lazzarin A,Zanussi C

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  • Monoclonal antibodies specific for variable and constant domains of murine lambda chains.

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Bogen B

    更新日期:1989-03-01 00:00:00

  • A novel human anti-AXL monoclonal antibody attenuates tumour cell migration.

    abstract::TAM family members (TYRO3, AXL and MERTK) play essential roles in the resolution of inflammation and in infectious diseases and cancer. AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous hematopoietic malignancies including acute myeloid leukaemia, acute lymphocytic leukae...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Duan Y,Luo L,Qiao C,Li X,Wang J,Liu H,Zhou T,Shen B,Lv M,Feng J

    更新日期:2019-08-01 00:00:00

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    abstract::Phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN) on the surface of endothelial cells is accompanied by adherence of the PMN to the endothelial surface and detachment of the endothelial cells from the culture monolayer. We studied the role of the leucocyte adherence-related glycoprotein...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Vandenbroucke-Grauls CM,Thijssen HM,Tetteroo PA,Rozemuller E,Verhoef J

    更新日期:1989-07-01 00:00:00

  • Development of immunoglobulin A in infancy and childhood.

    abstract::Serum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P < 0.001) during childhood. The salivary IgA1/IgA2 ratio tended to decrease during the same period; this trend is less apparent ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Weemaes C,Klasen I,Göertz J,Beldhuis-Valkis M,Olafsson O,Haraldsson A

    更新日期:2003-12-01 00:00:00

  • Selective cytotoxicity of two rodent T cell lymphomas to rat yolk sac tumours involves a retroviral envelope protein expressed by the lymphoma.

    abstract::A Gross virus induced rat T cell lymphoma G1-Tc1 and a Moloney virus induced mouse T cell lymphoma YAC-1 are shown to exert a strong cytotoxic activity against rat yolk sac tumours but not to various types of rat, mouse or human normal cells or tumour cell lines including carcinomas, sarcomas, lymphomas and gliomas. B...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lindvall M,Eriksson H,Hedlund G,Sjögren HO

    更新日期:1997-11-01 00:00:00

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Vilaplana C,Ruiz-Manzano J,Gil O,Cuchillo F,Montané E,Singh M,Spallek R,Ausina V,Cardona PJ

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    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: van Overveld FJ,Terpstra GK,Bruijnzeel PL,Raaijmakers JA,Kreukniet J

    更新日期:1988-01-01 00:00:00