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Altered IL-1 beta and IL-2 mRNA expression in murine splenic cells after concomitant stimulation by Semliki Forest virus and lipopolysaccharide.

Abstract：

:Co-infection with virus and bacteria happens frequently and often results in an exacerbated clinical course of the disease, possibly due to mechanisms including altered cytokine production. In the present study, the authors investigated the combined effects of avirulent Semliki Forest virus (SFV-A7) and bacterial lipopolysaccharide (LPS) on the interleukin-1 beta (IL-1 beta) and IL-2 gene expression in murine splenic cells. The authors found that 10 ng/ml of LPS in the culture medium induced expression of IL-1 beta but not IL-2, while infection with SFV-A7 did not induce either of these two cytokines. However, when SFV-A7 and LPS were applied together, a synergistic increase of both IL-1 beta and IL-2 was observed. Further experiments showed that addition of SFV-A7 3 h before LPS enhanced, whereas addition of the virus 3 h after the LPS inhibited, IL-1 beta gene expression. These results indicate that an interaction of virus and Gram-negative bacteria can result in an altered cytokine gene expression.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Yang J,Hukkanen V,Seljelid R,Salmi AA

doi

10.1046/j.1365-3083.1997.d01-406.x

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

349-53

issue

4

eissn

0300-9475

issn

1365-3083

journal_volume

45

pub_type

杂志文章

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