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Cellular and molecular characteristics of transformed T cells from an antigen-specific T-cell line.

Abstract：

:An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was poly-, oligo-, or monoclonal. The results indicate that the T lymphoma has no chromosome abnormalities, contains no tumour-inducing virus, can induce clone-specific immunity, and is oligoclonal with respect to TcR V alpha and V beta expression. The nature of the transformation event and clinical application of vaccination against T lymphomas is discussed. In addition, the expressed TcR V alpha and V beta repertoire of Con A T blasts was apparently not affected by the Igh-l or the MHC haplotype, as investigated in Igh-l and MHC congeneic C57Bl mice.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Wegener AM,Holm B,Geisler C,Rubin B

doi

10.1111/j.1365-3083.1990.tb02815.x

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

645-56

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

31

pub_type

杂志文章

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