Regulation of interleukin-6 production in human fetal Kupffer cells.

abstract：:The role of Lyt 1+ T-cell-derived secondard CTL inducing factor allowed the cloning of alloreactive cytotoxic T lymphocytes (CTL) by the limiting dilution approach. Several monoclonal cell lines were established in vitro. The lytic activity of some of the cell lines exceeded that of CTL from bulk cultures; that is, 50...

journal_title：Scandinavian journal of immunology

authors： Schawaller R,Röllinghoff M,Wagner H

更新日期：1980-01-01 00:00:00

abstract：:Antibodies forming a complex with antigen in vivo can dramatically change the antibody response to this antigen. In some situations, the response will be a 100-fold stronger than in animals immunized with antigen alone, and in other situations, the response will be completely suppressed. IgG is known to suppress the a...

journal_title：Scandinavian journal of immunology

authors： Xu H,Heyman B

更新日期：2020-10-01 00:00:00

abstract：:To evaluate the level of lymphocyte activation in reactive and rheumatoid arthritis, density gradient-isolated, synovial fluid mononuclear cells were stained with a panel of antisera directed at lymphocyte activation markers using an avidin-biotin-peroxidase complex (ABC) method. More specifically, we studied the expr...

journal_title：Scandinavian journal of immunology

authors： Konttinen YT,Nordström D,Bergroth V,Leirisalo-Repo M,Skrifvars B

更新日期：1986-06-01 00:00:00

abstract：:Serum exerts several effects in lymphocyte cultures, one of them being manifested very early. The presence of fetal calf serum (FCS) results in a markedly higher thymidine uptake within a few minutes, as compared with serum-free cultures. On the other hand, the uptake of uridine and other purine bases seem to be littl...

journal_title：Scandinavian journal of immunology

authors： Kristensen F,Joncourt F,de Weck AL

更新日期：1981-08-01 00:00:00

abstract：:We examined the effects of CD86 ligation on surface densities of CD80 on activated B cells. For this, splenic B cells where CD86 levels had been enhanced upon anti-immunoglobulin M (IgM) treatment were employed. Incubation of such CD86-expressing B cells with anti-CD86 monoclonal antibody (MoAb) resulted in a marked u...

journal_title：Scandinavian journal of immunology

authors： Sahoo NC,Rao KV,Natarajan K

更新日期：2002-06-01 00:00:00

abstract：:We have previously reported that a cytosolic alkaline fraction (FI) obtained from epimastigotes of Trypanosoma cruzi promotes the activation, proliferation and differentiation of normal murine B cells into antibody-secreting plasmocytes. Neither the mechanism nor the cells involved in the FI-induced polyclonal B-cell ...

journal_title：Scandinavian journal of immunology

authors： Montes CL,Zuñiga E,Minoprio P,Vottero-Cima E,Gruppi A

更新日期：1999-08-01 00:00:00

abstract：:Hypoxia is a prominent microenvironment feature in a range of disorders including cancer, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel disease (IBD), infection and obesity. Hypoxia promotes biological functions of fibroblast-like synoviocytes via regulating hypoxia-inducible factor 1α (HIF1α). Dysreg...

journal_title：Scandinavian journal of immunology

authors： Yu R,Li C,Sun L,Jian L,Ma Z,Zhao J,Liu X

更新日期：2018-04-01 00:00:00

abstract：:The role of several adhesion molecules for lymphocyte-endothelial interactions in the synovia of rheumatoid arthritis patients was studied using the frozen section assay. Partial inhibition of lymphocyte binding to endothelium of synovial sections could be observed with antibodies against CD44, L-selectin, and beta 1-...

journal_title：Scandinavian journal of immunology

authors： Fischer C,Thiele HG,Hamann A

更新日期：1993-08-01 00:00:00

abstract：:Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin-3 in patients with newly diagnosed RA and associations with disease profile, Magnetic resonance imaging (MRI) findings and seromarkers of synovial matrix inflamm...

journal_title：Scandinavian journal of immunology

authors： Issa SF,Christensen AF,Lindegaard HM,Hetland ML,Hørslev-Petersen K,Stengaard-Pedersen K,Ejbjerg BJ,Lottenburger T,Ellingsen T,Pedersen JK,Junker K,Svendsen A,Tarp U,Østergaard M,Junker P

更新日期：2017-12-01 00:00:00

abstract：:This study describes Leishmania antigen-induced activation of lymphocytes isolated from Kenyan donors, previously treated for visceral leishmaniasis, and from Danish and Kenyan controls. Peripheral blood mononuclear cells (PBMC) from cured Kala-Azar patients proliferated and produced Interferon-gamma in vitro in respo...

journal_title：Scandinavian journal of immunology

authors： Kemp M,Theander TG,Handman E,Hey AS,Kurtzhals JA,Hviid L,Sørensen AL,Were JO,Koech DK,Kharazmi A

更新日期：1991-02-01 00:00:00

abstract：:To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by immunohistochemistry, and apoptotic cells by the terminal deoxynucleotidyl-transferase-mediated dUTP-dig...

journal_title：Scandinavian journal of immunology

authors： Mustafa T,Bjune TG,Jonsson R,Pando RH,Nilsen R

更新日期：2001-12-01 00:00:00

abstract：:Immunotherapy using dendritic cells (DC) has shown promising results. However, the use of an appropriate DC population is critical for the outcome of this treatment, and the search for an optimal DC subset is still ongoing. The DC used in immunotherapy today are usually matured with a cytokine cocktail consisting of T...

journal_title：Scandinavian journal of immunology

authors： Karlsen M,Hovden AO,Vogelsang P,Tysnes BB,Appel S

更新日期：2011-08-01 00:00:00

abstract：:Histoplasma capsulatum is a fungus found intracellularly in neutrophils and peripheral blood mononuclear cells (PBMCs), suggesting that it is capable of evading damage and survives inside these cells. In this study, we report that neutrophils from H. capsulatum-infected mice, and human neutrophils and mononuclear cell...

journal_title：Scandinavian journal of immunology

authors： Medeiros AI,Bonato VL,Malheiro A,Dias AR,Silva CL,Faccioli LH

更新日期：2002-10-01 00:00:00

abstract：:During the germinal centre reaction (GC), B cells with non-functional or self-reactive antigen receptors are negatively selected by apoptosis to generate B cell repertoire with appropriate antigen specificities. We studied the molecular mechanism of Fas/CD95- and B cell receptor (BCR)-induced apoptosis to shed light o...

journal_title：Scandinavian journal of immunology

authors： Eeva J,Nuutinen U,Ropponen A,Mättö M,Eray M,Pellinen R,Wahlfors J,Pelkonen J

更新日期：2009-12-01 00:00:00

abstract：:Eosinophil granulocytes are intriguing members of the innate immunity system that have been considered important defenders during parasitic diseases as well as culprits during allergy-associated inflammatory diseases. Novel studies have, however, found new homoeostasis-maintaining roles for the cell. Recent clinical t...

journal_title：Scandinavian journal of immunology

authors： Amin K,Janson C,Bystrom J

更新日期：2016-08-01 00:00:00

abstract：:We have depleted lymphocyte subsets in PVG and AO rats with MoAbs 3.2.3 (against NKR-P1 on NK and NK/T cells) and OX-8 (against CD8 on CTL and NK cells), and examined the effect on the killing of YAC-1 target cells in vitro and the effect on the acute rejection of small allogeneic lymphocytes in vivo (allogeneic lymph...

journal_title：Scandinavian journal of immunology

authors： Løvik G,Vaage JT,Rolstad B,Naper C

更新日期：2001-10-01 00:00:00

abstract：:Crude preparations of platelet-activating factors (PAF) derived by methanolic extraction of supernatants from antigen-challenged basophils generally stimulated the secretion of histamine from human peripheral blood leucocytes when co-incubated with these cells in the absence of an additional stimulator. When these cru...

journal_title：Scandinavian journal of immunology

authors： O'Donnell MC,Fiedel BA

更新日期：1981-01-01 00:00:00

abstract：:Hypomorphic mutations in the gene encoding Bruton tyrosine kinase (BTK) may result in milder phenotypes and delayed diagnosis of B-cell related immunodeficiencies due to residual BTK function. Newborn screening for kappa-deleting-recombination-excision circles (KRECs) reliably identifies classical X-linked agammaglobu...

journal_title：Scandinavian journal of immunology

authors： Krüger R,Baumann U,Borte S,Kölsch U,Lorenz MR,Keller B,Harder I,Warnatz K,Ehl S,Schwarz K,Wahn V,von Bernuth H

更新日期：2020-01-01 00:00:00

abstract：:C57BL/6 mice treated with intranasal instillation of 100 micrograms of Aspergillus antigen three times a week developed a pulmonary eosinophilia, observed in the bronchoalveolar lavage (BAL) and on histopathological examination. At week 3, the instillation of Aspergillus antigen provoked a 10-fold increase in the BAL ...

journal_title：Scandinavian journal of immunology

authors： Wang JM,Denis M,Fournier M,Laviolette M

更新日期：1994-01-01 00:00:00

abstract：:It was reported that the expression of Toll-like receptor (TLR) 9 may be related to Th2-type allergic inflammation including allergic rhinitis (AR). However, little is known about the expression of TLR9 in the basophils in AR. In the present study, the expression of TLR9 was examined by flow cytometry analysis, and th...

journal_title：Scandinavian journal of immunology

authors： Zhong Q,Zhan M,Wang L,Chen D,Zhao N,Wang J,Huang Y,Zhang X,He S,Zhang H

更新日期：2020-11-28 00:00:00

abstract：:KIR2DL2 and KIR2DL3 are important inhibitory receptors that recognize a subset of HLA-C allelic products carrying Ser77 and Asn80. In this study, we have determined KIR2DL2 and KIR2DL3 diversity in the Chinese Han population by a PCR sequence-based typing. Based on sequencing, the coding regions of 166 Chinese Han ind...

journal_title：Scandinavian journal of immunology

authors： He Y,Tao S,Ying Y,He J,Zhu F,Lv H

更新日期：2015-04-01 00:00:00

abstract：:CD4+ T cells are the central element of the adaptive immune responses and protect the body from a variety of pathogens. Starting from naive cells, CD4+ T cells can differentiate into various effector cell subsets with specialized functions including T helper (Th) 1, Th2, Th17, regulatory T (Treg) and T follicular help...

journal_title：Scandinavian journal of immunology

authors： Wan Z,Zhou Z,Liu Y,Lai Y,Luo Y,Peng X,Zou W

更新日期：2020-05-01 00:00:00

abstract：:Cellular immune response and delayed-type hypersensitivity reactions are considered to play a major role in the immunopathogenesis of pulmonary tuberculosis (PTB). But the exact mechanism is still to be clarified. Th1 cells are mainly involved in cellular immune responses in PTB and provide a normal healing process wi...

journal_title：Scandinavian journal of immunology

authors： Aktas E,Ciftci F,Bilgic S,Sezer O,Bozkanat E,Deniz O,Citici U,Deniz G

更新日期：2009-09-01 00:00:00

abstract：:Serum Amyloid A (SAA) is an acute-phase protein secreted mainly by hepatocytes and is largely associated with high-density lipoprotein (HDL) in plasma. It has been suggested that SAA alters HDL binding to the cell surface and that this in turn changes HDL-mediated cholesterol delivery to cells. Incorporation of SAA in...

journal_title：Scandinavian journal of immunology

authors： Hayat S,Raynes JG

更新日期：2000-02-01 00:00:00

abstract：:Peripheral blood lymphocytes from 43 patients with systemic lupus erythematosus (SLE) and from age- and sex-matched normal controls were cultured with lipopolysaccharide (LPS) to examine the response to the polyclonal B-cell activator. Lymphocytes from active SLE patients incorporated 4840 +/- 471 (mean +/- SE) cpm in...

journal_title：Scandinavian journal of immunology

authors： Abe T,Toguchi T,Takeuchi T,Kiyotaki M,Homma M

更新日期：1981-05-01 00:00:00

abstract：:Gαq, the alpha subunit of Gq, a member of the Gq/11 sub-family, was reported to inhibit phosphatidylinositol-3-Kinase (PI3K) activation and prevent the activation of Akt. Previous studies demonstrated that mice losing Gαq in their immune system could spontaneously develop inflammatory arthritis. In this study, we show...

journal_title：Scandinavian journal of immunology

authors： Wang Y,Li Y,He Y,Sun Y,Sun W,Xie Q,Yin G,Du Y,Wang L,Shi G

更新日期：2012-02-01 00:00:00

abstract：:Using a recently developed murine model of haematogenously induced Staphylococcus aureus, the authors have characterized the phenotypes and functional properties of inflammatory cells present in the synovium of arthritic mice. The results show that large numbers of granulocytes and macrophages were observed in the inf...

journal_title：Scandinavian journal of immunology

authors： Abdelnour A,Bremell T,Holmdahl R,Tarkowski A

更新日期：1994-04-01 00:00:00

abstract：:Midtrimester amniotic fluid cytokines may reflect the function of the maternal immune system in the maternal-fetal interface and thus be predictive of pre-eclampsia. We determined the concentrations of interleukin (IL)-6, IL-8, IL-10, IL-11, IL-12, IL-15, tumour necrosis factor (TNF)-alpha and transforming growth fact...

journal_title：Scandinavian journal of immunology

authors： Heikkinen J,Möttönen M,Pulkki K,Lassila O,Alanen A

更新日期：2001-03-01 00:00:00

abstract：:Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children req...

journal_title：Scandinavian journal of immunology

authors： Karnabi E,Boutjdir M

更新日期：2010-09-01 00:00:00

abstract：:Denaturing high-performance liquid chromatography (DHPLC) was evaluated as a tool for diagnostic screening of polymorphisms in the tumour necrosis factor receptor superfamily member 6 (TNFRSF6) also known as CD95, Apo-1 or Fas gene. Exons 1-9 of the TNFRSF6 gene were amplified from genomic DNA of 38 individuals, of wh...

journal_title：Scandinavian journal of immunology

authors： Etokebe GE,Abrahamsen TG,Bogen B,Spurkland A

更新日期：2004-05-01 00:00:00