CD80 expression is induced on activated B cells following stimulation by CD86.


:We examined the effects of CD86 ligation on surface densities of CD80 on activated B cells. For this, splenic B cells where CD86 levels had been enhanced upon anti-immunoglobulin M (IgM) treatment were employed. Incubation of such CD86-expressing B cells with anti-CD86 monoclonal antibody (MoAb) resulted in a marked upregulation in cell surface levels of CD80. Such an enhancement in surface levels was also accompanied by a marked increase in CD80 mRNA, suggesting that the effects of CD86-triggering are exerted at the level of CD80 message. Furthermore, coculture of CD86-upregulated B cells with CD28-expressing fibroblasts also led to the enhancement of CD80 levels, which was not obtained upon incubation with cells expressing cytotoxic T-lymphocyte-associated molecule (CTLA)-4-Ig. Finally, we also demonstrate that CD86-induced CD80 is fully competent to function as a costimulatory molecule, as revealed by its ability to enhance cytokine secretion by allogeneic T cells. Thus, these results reveal the existence of another pathway that regulates the expression of CD80, at least on activated B cells, which could have important implications in directing the course of an immune response.


Scand J Immunol


Sahoo NC,Rao KV,Natarajan K





Has Abstract


2002-06-01 00:00:00














  • Rabbit spleen B lymphocytes as helper cells in lymphocyte activation by concanavalin A and phytohaemagglutinin.

    abstract::Using rosetting methods, we have purified rabbit B cells and studied their interactions with T cells purified by passage over an anti-immunoglobulin-coated Degalan beads column. B cells enhance the response of T cells to concanavalin A (Con A) and phytohaemagglutinin. In regulation of the response to Con A, an adheren...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Cavaillon JM,Udupa TN,Chou CT,Cinader B,Dubiski S

    更新日期:1982-01-01 00:00:00

  • Reactive oxygen species selectively deplete normal T lymphocytes via a hydroxyl radical dependent mechanism.

    abstract::Chronic inflammatory synovitis is characterized by both lymphocytic infiltrates and persistent polymorph exudates. Activated polymorphs release reactive oxygen species (ROS) during inflammation, but the contribution that these make to the lymphocyte abnormalities associated with RA has been little studied. We therefor...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Allan IM,Lunec J,Salmon M,Bacon PA

    更新日期:1987-07-01 00:00:00

  • Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex.

    abstract::The fluid-phase terminal complement complex (TCC), consisting of the components C5b, C6, C7, C8, C9, and the S-protein, has recently been detected in normal human plasma by using antibodies against native terminal complement components. Increased amounts of TCC were then found in several patients with in vivo activati...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Mollnes TE,Lea T,Frøland SS,Harboe M

    更新日期:1985-08-01 00:00:00

  • Modulation of host immune responses by overexpression of immunodominant antigens of Mycobacterium tuberculosis in bacille Calmette-Guérin.

    abstract::Based on their immunodominant nature and ability to induce appropriate immune responses in the host, several antigens of Mycobacterium tuberculosis have shown promise of protection. However, most of the candidate vaccines developed by employing various strategies have afforded protection that is at best comparable wit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Rao V,Dhar N,Tyagi AK

    更新日期:2003-10-01 00:00:00

  • Three-point association of HLA-A,B,Bf haplotypes deduced in 200 parents of 100 families.

    abstract::The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters,...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Albert ED,Rittner C,Scholz S,Kuntz B,Mickey MR

    更新日期:1977-01-01 00:00:00

  • Inhibition of de novo IgM antibody synthesis by thalidomide as a relevant mechanism of action in leprosy.

    abstract::Thalidomide is well documented to be an effective treatment for erythema nodosum leprosum (ENL) occurring in lepromatous leprosy. To be beneficial, thalidomide must interfere with one or more of the several essential steps in the pathogenesis of this syndrome, which is presumed to be a clinical manifestation of an Art...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Shannon EJ,Miranda RO,Morales MJ,Hastings RC

    更新日期:1981-01-01 00:00:00

  • Cellular interactions between synovial T-cell clones from a patient with rheumatoid arthritis.

    abstract::The aim of this study was to investigate T-T cell interactions that may be involved in the pathogenesis of chronic synovitis. Two CD4+ T-cell clones, termed N16 and N18, sharing similar cytokine profiles were isolated from the synovial tissue of a patient with rheumatoid arthritis. Activated N16 cells induced prolifer...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Van Laar JM,Miltenburg AM,De Kuiper P,Daha MR,De Vries RR,Breedveld FC

    更新日期:1993-06-01 00:00:00

  • Adhesive interactions between human NK cells and porcine endothelial cells.

    abstract::Human natural killer (NK) cells are able to adhere to xenogeneic porcine endothelial cells (EC) and evidence from in vitro studies as well as animal models suggests a potential role for NK cells in the cellular recognition and damage of porcine xenogeneic tissues. One possible explanation for the observed NK cell-medi...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审


    authors: Schneider MK,Forte P,Seebach JD

    更新日期:2001-07-01 00:00:00

  • Ex vivo responses for interferon-gamma and proinflammatory cytokine secretion to low-molecular-weight antigen MTB12 of Mycobacterium tuberculosis during human tuberculosis.

    abstract::MTB12 protein, also called CFP-2, is a major and early secreted component of Mycobacterium tuberculosis. However, its role during mycobacterial infection has been poorly characterized. In this study, we purified the native MTB12 protein and investigated the profile of MTB12-induced cytokines [interferon (IFN)-gamma, t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Lee JS,Son JW,Jung SB,Kwon YM,Yang CS,Oh JH,Song CH,Kim HJ,Park JK,Paik TH,Jo EK

    更新日期:2006-08-01 00:00:00

  • Binding of a bacterial acylpoly(1,3)galactoside to human blood leucocytes.

    abstract::The binding of a 34-kDa (mol. wt.) acylpoly(1,3)galactoside (APG) extracted from a membrane proteoglycan of Klebsiella pneumoniae to human blood leucocytes was investigated. APG is made of a long poly(1,3)galactose chain, a core-like region and a lipid moiety which comprises two glucosamine residues bound to a phospha...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Hmama Z,Kouassi E,Panaye G,Delassan S,Normier G,Binz H,Revillard JP

    更新日期:1992-07-01 00:00:00

  • An altered response by psoriatic keratinocytes to gamma interferon.

    abstract::To determine whether psoriatic keratinocytes differ from normal keratinocytes in their response to gamma interferon, epidermal cell suspensions from normal and from lesional and uninvolved psoriatic skin were cultured in the presence of gamma interferon and the induction of HLA-DR expression and inhibition of cell gro...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Baker BS,Powles AV,Valdimarsson H,Fry L

    更新日期:1988-12-01 00:00:00

  • Bacteriostatic activity of BCG/PPD-activated macrophages against Mycobacterium fortuitum does not involve reactive nitrogen or oxygen intermediates.

    abstract::Mycobacteria preferentially reside in resident macrophages whereas activated macrophages are presumed to eliminate the bacteria effectively. The aim of the present study was to determine the antibacterial activities of resident and activated murine peritoneal macrophages against Mycobacterium fortuitum and the intrace...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Nibbering PH,Yoshida SI,van den Barselaar MT,van Furth R

    更新日期:1994-08-01 00:00:00

  • Selective increase in blood dendritic cell antigen-3-positive dendritic cells in bronchoalveolar lavage fluid in allergic patients.

    abstract::Dendritic cells (DCs) are specific antigen-presenting cells that play critical roles in the initiation and polarization of immune responses. DCs residing in the lungs might be detected in the bronchoalveolar lavage fluid (BALF). We analysed DC compartment in the peripheral blood and BALF of patients with allergy and i...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kayserova J,Zentsova-Jaresova I,Budinsky V,Rozkova D,Kopecka J,Vernerova E,Pohunek P,Skalicka V,Spisek R,Sediva A

    更新日期:2012-03-01 00:00:00

  • Structural analysis of VH4-21 encoded human IgM allo- and autoantibodies against red blood cells.

    abstract::We have sequenced the variable heavy chain regions of a number of VH4-21 encoded monoclonal IgM anti-Rh(D) antibodies produced in response to deliberate immunization. These were compared with the sequences of similarly encoded IgM anti-I cold agglutinins (CA) derived from patients with lympho-proliferative diseases. T...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Børretzen M,Chapman C,Stevenson FK,Natvig JB,Thompson KM

    更新日期:1995-07-01 00:00:00

  • Altered natural killer and natural cytotoxic cellular activities in lpr mice.

    abstract::Three strains of mice bearing the autosomal recessive lpr gene (MRL, C57BL/6, and C3H) that had spontaneously developed a lupus-like disease were studied sequentially for functional natural killer (NK) and natural cytotoxic (NC) cell activity. Natural killing was impaired in spleen and bone marrow cells from all the l...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Pan LZ,Dauphinée MJ,Ansar Ahmed S,Talal N

    更新日期:1986-04-01 00:00:00

  • Citrullination of self-proteins and autoimmunity.

    abstract::Citrullination (deimination is an enzymatic, posttranslational conversion of arginine residues to citrulline residues) of joint-associated self-proteins may be a possible mechanism in the induction of autoimmune CD4 T-cell responses in rheumatoid arthritis. We have studied the immune response to normal or deiminated h...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Rubin B,Sønderstrup G

    更新日期:2004-07-01 00:00:00

  • Specific deposition of serum amyloid A protein 2 in the mouse.

    abstract::The homogenates of amyloid-laden spleens prepared from CBA mice were analysed by SDS-PAGE and immunoblotting employing rat anti-murine monoclonal antibody, MSA 4-26. The results showed that the precursor of amyloid A protein (AA), serum amyloid A protein 2 (SAA2), and SAA intermediates with molecular weights of 10,000...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Shiroo M,Kawahara E,Nakanishi I,Migita S

    更新日期:1987-12-01 00:00:00

  • Inhibition by Artocarpus tonkinensis of the development of collagen-induced arthritis in rats.

    abstract::Extracts of the leaves and roots from the tree Artocarpus tonkinensis A Cheval (family Moraceae) are used in traditional Vietnamese medicine in order to treat backache as well as rheumatic joint diseases. We prepared an ethyl acetate (EtOAc) extract from this plant and tested its anti-inflammatory properties in an exp...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Ngoc DD,Catrina AI,Lundberg K,Harris HE,Ha NT,Anh PT,Larsson P

    更新日期:2005-03-01 00:00:00

  • CD4+Foxp3+ regulatory T-cell impairment by paclitaxel is independent of toll-like receptor 4.

    abstract::Paclitaxel (PTX) is one of the most widely used clinical antitumour drugs in chemotherapy nowadays. Its effect on immune system has become a hot spot of research in recent years. Here, we demonstrated that PTX not only decreased the percentage of CD4+Foxp3+ regulatory T (Treg) cells both in vitro and in vivo but also ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Zhu Y,Liu N,Xiong SD,Zheng YJ,Chu YW

    更新日期:2011-04-01 00:00:00

  • T-cell receptor V-gene usage in synovial fluid and synovial tissue from RA patients.

    abstract::The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Gudmundsson S,Rönnelid J,Karlsson-Parra A,Lysholm J,Gudbjörnsson B,Widenfalk B,Janson CH,Klareskog L

    更新日期:1992-11-01 00:00:00

  • Hypothesis for the control of clotting factor VIII inhibitory antibodies by decreasing potency of helper T-cell-recognized epitopes in factor VIII.

    abstract::The study of the immunobiology of FVIII inhibitors may lead to new therapies for this potentially severe complication of haemophilia A and to new principles for the use of therapeutic proteins. In order to characterize the idiotype-anti-idiotype networks regulating FVIII inhibitors, we developed rabbit anti-idiotypic ...

    journal_title:Scandinavian journal of immunology

    pub_type: 社论,评审


    authors: Tiarks C,Humphreys RE,Anderson J,Mole J,Pechet L

    更新日期:1992-11-01 00:00:00

  • Vitamin A supplementation reduces IL-17 and RORc gene expression in atherosclerotic patients.

    abstract::Vitamin A is a potential mediator of T helper cells in atherosclerosis. The purpose of this study was to evaluate the effect of vitamin A supplementation on expression of Th17 cells-related IL-17 and RORc genes in atherosclerotic patients. Thirty one atherosclerotic patients and 15 healthy controls were studied for 4 ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,随机对照试验


    authors: Mottaghi A,Ebrahimof S,Angoorani P,Saboor-Yaraghi AA

    更新日期:2014-08-01 00:00:00

  • Immunomodulatory effects of Lactobacillus casei administration in a mouse model of gliadin-sensitive enteropathy.

    abstract::Coeliac disease (CD) is a very common food-sensitive enteropathy, which is triggered by gluten ingestion and is mediated by CD4(+) T cells. In addition, alterations in the intestinal microbiota that is normally involved in the homeostasis of GALT (gut-associated lymphoid tissue) seem to play a role in CD. In accordanc...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: D'Arienzo R,Stefanile R,Maurano F,Mazzarella G,Ricca E,Troncone R,Auricchio S,Rossi M

    更新日期:2011-10-01 00:00:00

  • Quantification of cytokine gene expression using an economical real-time polymerase chain reaction method based on SYBR Green I.

    abstract::Assessment of cytokine expression has become crucial to understand host responses to infections as well as autoimmunity. Several approaches including Northern blot, RNase protection assay and enzyme-linked immunosorbent assay have been used for this purpose, but they are time consuming, labour intense, and relatively ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Ramos-Payán R,Aguilar-Medina M,Estrada-Parra S,González-Y-Merchand JA,Favila-Castillo L,Monroy-Ostria A,Estrada-Garcia IC

    更新日期:2003-05-01 00:00:00

  • Participation of iNKT cells in the early and late components of Tc1-mediated DNFB contact sensitivity: cooperative role of γδ-T cells.

    abstract::Prior studies of classical 24 h responses in TNP-Cl (picryl chloride) allergic contact sensitivity (CS), showed mediation by Th1 cells in CBA mice, and established that 24 h elicitation of responses requires an early 2 h CS-initiating component dependent on iNKT cells, IL-4 and B-1 B cells. Here, we studied the other ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Askenase PW,Majewska-Szczepanik M,Kerfoot S,Szczepanik M

    更新日期:2011-05-01 00:00:00

  • Multiple sclerosis: cells secreting antibodies against myelin-associated glycoprotein are present in cerebrospinal fluid.

    abstract::We evaluated the B-cell response in cerebrospinal fluid (CSF) and blood by enumerating cells secreting antibodies to myelin-associated glycoprotein (MAG) and, for reference, to myelin basic protein (MBP), two myelin components which may constitute targets for autoimmune attack in multiple sclerosis (MS). Among 25 untr...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Baig S,Olsson T,Yu-Ping J,Höjeberg B,Cruz M,Link H

    更新日期:1991-01-01 00:00:00

  • Development of immunoglobulin A in infancy and childhood.

    abstract::Serum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P < 0.001) during childhood. The salivary IgA1/IgA2 ratio tended to decrease during the same period; this trend is less apparent ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Weemaes C,Klasen I,Göertz J,Beldhuis-Valkis M,Olafsson O,Haraldsson A

    更新日期:2003-12-01 00:00:00

  • Heterogeneity and mechanism of action of human natural killer lymphocytes: differential distribution of receptors for Helix pomatia haemagglutinin (HP receptors).

    abstract::Neuraminidase-treated lymphocytes from the peripheral blood of normal human donors were fractionated on columns charged with Helix pomatia haemagglutinin (HP) coupled to Sepharose 4B. While lymphocytes lacking HP receptors (HP-) passed directly through the column (fraction I), lymphocytes with HP receptors (HP+) were ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Pape GR,Troye M,Perlmann P

    更新日期:1979-01-01 00:00:00

  • Effect of interferon on cell proliferation and generation of cytotoxic potential in mixed autologous and allogeneic lymphocyte cultures.

    abstract::Autologous and allogeneic mixed lymphocyte cultures (AMC and MLC) were assayed for blastogenesis, generation of cytotoxic potential, and the effect of interferon (IFN-alpha) on these features. The cells of the mixed cultures lysed K562, Daudi, and autologous and allogeneic phytohaemagglutinin blasts. Stimulator-specif...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Argov S,Klein E

    更新日期:1983-03-01 00:00:00

  • Blockade of the B7-CD28 pathway by CTLA4-Ig counteracts rejection and prolongs survival in small bowel transplantation.

    abstract::Allograft rejection involves T-cell activation, requiring T-cell receptor interactions with major histocompatibility complex (MHC) molecules and costimulatory signals delivered through the B7-CD28 pathway. We evaluated the effect of blocking this pathway on graft rejection and survival, in a rat experimental model of ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章


    authors: Kurlberg G,Haglind E,Schön K,Törnqvist H,Lycke N

    更新日期:2000-03-01 00:00:00