Fine specificity and cytolytic activity of continuously growing alloreactive cytotoxic T lymphocyte clones.

abstract：:We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody...

journal_title：Scandinavian journal of immunology

authors： Kaplan MH,Alhasan S,Rosenspire A,Sundick RS

更新日期：1993-08-01 00:00:00

abstract：:The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that...

journal_title：Scandinavian journal of immunology

authors： Gudmundsson S,Rönnelid J,Karlsson-Parra A,Lysholm J,Gudbjörnsson B,Widenfalk B,Janson CH,Klareskog L

更新日期：1992-11-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that leads to substantial suffering for millions of patients. In some patients, the chronic inflammation leads to remodelling of the extracellular matrix and fibrosis. Fibrosis, in combination with expansion of smooth muscle layers, l...

journal_title：Scandinavian journal of immunology

authors： Alfredsson J,Wick MJ

更新日期：2020-12-01 00:00:00

abstract：:Antigen 60 (A60), a member of the thermostable macromolecular antigen family (TMA) and main component of old tuberculin and purified protein derivative (PPD), has been purified from the cytoplasm of Mycobacterium bovis BCG; its structure and metabolism have already been described. In the present paper, the action of A...

journal_title：Scandinavian journal of immunology

authors： Cocito C,Baelden MC,Benoit C

更新日期：1987-06-01 00:00:00

abstract：:RUTI is a vaccine consisting of Mycobacterium tuberculosis bacilli grown in stress conditions that is fragmented, detoxified and liposomed. RUTI was designed to shorten the treatment of latent tuberculosis infection (LTBI) with isoniazid from 9 months to just 1 month, by additional treatment with two inoculations of R...

journal_title：Scandinavian journal of immunology

authors： Vilaplana C,Ruiz-Manzano J,Gil O,Cuchillo F,Montané E,Singh M,Spallek R,Ausina V,Cardona PJ

更新日期：2008-06-01 00:00:00

abstract：:To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irrad...

journal_title：Scandinavian journal of immunology

authors： Colucci F,Bergman ML,Lejon K,Holmberg D

更新日期：1998-12-01 00:00:00

abstract：:Many patients with inflammatory bowel disease (IBD) are undergoing therapy with infliximab, an antibody specific for TNF. However, the exact mechanisms of action of infliximab are not completely understood. The aim of this study was to determine the in vitro effects of infliximab on blood T cells derived from anti-TNF...

journal_title：Scandinavian journal of immunology

authors： Dahlén R,Strid H,Lundgren A,Isaksson S,Raghavan S,Magnusson MK,Simrén M,Sjövall H,Öhman L

更新日期：2013-09-01 00:00:00

abstract：:Interleukin-1 (IL-1) production by the human monocyte-like cloned cell line CM-SM has been investigated as a function of the state of cell differentiation. CM-SM cells were induced to differentiate along the monocyte-macrophage lineage by bacterial lipopolysaccharides (LPS) or by 12-O-tetradecanoyl-phorbol-13-acetate ...

journal_title：Scandinavian journal of immunology

authors： Revoltella RP,Butler RH,Musiani P,Piantelli M,Ranelletti FO

更新日期：1985-01-01 00:00:00

abstract：:The objective of this study was to evaluate whether major abdominal surgery leads to complement activation and interleukin response and whether the kind of anaesthesia influence complement activation and the release of inflammatory interleukins. The study design was prospective and randomised. Fifty patients undergoin...

journal_title：Scandinavian journal of immunology

authors： Kvarnström AL,Sarbinowski RT,Bengtson JP,Jacobsson LM,Bengtsson AL

更新日期：2012-05-01 00:00:00

abstract：:In 10 blood samples from mothers who were studied after the delivery of a male infant and who had Y-body-containing cells in their circulations (mean value, 0.06%) the proportions of surface-Ig- and Y-body-positive lymphocytes were determined after passage through nylon wool. In each case one part of the sample was tr...

journal_title：Scandinavian journal of immunology

authors： Schröder J

更新日期：1975-01-01 00:00:00

abstract：:Cytotoxic responses of lymphoid cells from different mouse strains against syngeneic cells modified with the haptens fluorescein isothiocyanate and trinitrophenyl were investigated. Mic of the H-2k strain demonstrated strong primary in vitro hapten-specific cytotoxicity reactions, which were H-2 restricted and involve...

journal_title：Scandinavian journal of immunology

authors： Möller E,Ramos T

更新日期：1981-01-01 00:00:00

abstract：:Antibodies to interleukin-2 (IL-2) have been reported in the sera of patients under therapies involving this cytokine and in the sera of patients infected with human immunodeficiency virus (HIV). Our study proves that auto-antibodies to IL-2 are present also, at a lower titre, in healthy individuals. These antibodies ...

journal_title：Scandinavian journal of immunology

authors： Tiberio L,Caruso A,Pozzi A,Rivoltini L,Morelli D,Monti E,Balsari A

更新日期：1993-11-01 00:00:00

abstract：:A search for an antigen-driven expansion of T lymphocytes in the inflamed joints in rheumatoid arthritis (RA) patients have been going on for decades. We here analyzed the human germinal centre T-cell receptor (TCR) Vbeta gene usage with polymerase chain reaction (PCR) combined with sequence analysis, to address the q...

journal_title：Scandinavian journal of immunology

authors： Källberg E,Leanderson T,Natvig JB

更新日期：2001-09-01 00:00:00

abstract：:Severe hypercholesterolaemia is associated with decreased levels of immunoglobulin G2a (IgG2a) antibodies [T-helper 1 (Th1) response] to modified malondialdehyde-modified low-density lipoprotein (MDA-LDL) and increased levels of Th2-dependent IgG1 antibodies in apolipoprotein E-deficient (apoE(-/-)) mice. To investiga...

journal_title：Scandinavian journal of immunology

authors： Robertson AK,Zhou X,Strandvik B,Hansson GK

更新日期：2004-03-01 00:00:00

abstract：:We studied the inhibitory effect of a fraction of bovine seminal plasma on in vitro lymphocyte responses to specific and nonspecific ligands. Seminal plasma was fractionated by Sephadex G-100 chromatography, and the inhibitory component was found to have a molecular weight of above 100,000 daltons. This fraction was d...

journal_title：Scandinavian journal of immunology

authors： Prakash C,Coutinho A,Möller G

更新日期：1976-01-01 00:00:00

abstract：:Ficolin-2 (L-ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition molecule found in human serum in which inter-individual variation in serum appears to be under genetic control. To validate and extend this finding, we developed a sandwich ELISA for detection of human Ficolin-2 in serum sampl...

journal_title：Scandinavian journal of immunology

authors： Munthe-Fog L,Hummelshøj T,Hansen BE,Koch C,Madsen HO,Skjødt K,Garred P

更新日期：2007-04-01 00:00:00

abstract：:Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during whic...

journal_title：Scandinavian journal of immunology

authors： Nera KP,Kyläniemi MK,Lassila O

更新日期：2015-09-01 00:00:00

abstract：:The expression and function of neural cell adhesion molecule (NCAM, CD56, Leu19) on leukaemic blasts was investigated. The expression of NCAM was frequent (64%) in 14 studied cases of acute myeloid leukaemia (AML) but not in chronic lymphocytic leukaemia (CLL: 1/3 cases positive) or immunocytoma (IC: no positivity). N...

journal_title：Scandinavian journal of immunology

authors： Palucka AK,Porwit A,Reizenstein P

更新日期：1992-04-01 00:00:00

abstract：:The mammalian C-type serum lectin, mannan-binding protein (MBP), may induce C1q- and antibody-independent activation of the classical pathway of complement. Accordingly, MBP is considered as a member of the complement system. Complement deficiencies have been found with increased frequency in patients with meningococc...

journal_title：Scandinavian journal of immunology

authors： Garred P,Michaelsen TE,Bjune G,Thiel S,Svejgaard A

更新日期：1993-04-01 00:00:00

abstract：:Neural transplantation may become an important treatment alternative for focal brain disorders. To date, the most successful grafts have been obtained in patients with Parkinson's disease. Completely normalized dopamine production and reduction of Parkinsonian symptoms have been demonstrated 10 years after grafting. H...

journal_title：Scandinavian journal of immunology

authors： Larsson LC,Widner H

更新日期：2000-09-01 00:00:00

abstract：:Thirty-two mycobacterial components were detected by antibodies contained in leprosy patients' sera across the clinical spectrum and rabbit anti-M. leprae hyperimmune sera by western blot analysis of armadillo-derived M. leprae antigen preparations. Sera of borderline tuberculoid patients were found to contain antibod...

journal_title：Scandinavian journal of immunology

authors： Ehrenberg JP,Gebre N

更新日期：1987-12-01 00:00:00

abstract：:Haematopoietic precursors first colonizing the avian embryonic thymus are derived from the intraembryonic sites located around the dorsal aortae. These intraembryonic precursors have previously been demonstrated to include cells that harbour T-cell progenitor capacity and express the Ikaros transcription factor, known...

journal_title：Scandinavian journal of immunology

authors： Liippo J,Koskela K,Lassila O

更新日期：2000-11-01 00:00:00

abstract：:MTB12 protein, also called CFP-2, is a major and early secreted component of Mycobacterium tuberculosis. However, its role during mycobacterial infection has been poorly characterized. In this study, we purified the native MTB12 protein and investigated the profile of MTB12-induced cytokines [interferon (IFN)-gamma, t...

journal_title：Scandinavian journal of immunology

authors： Lee JS,Son JW,Jung SB,Kwon YM,Yang CS,Oh JH,Song CH,Kim HJ,Park JK,Paik TH,Jo EK

更新日期：2006-08-01 00:00:00

abstract：:Infection with murine gammaherpesvirus 68 has become an accepted model for studying the virus/host interactions with regard to gammaherpesvirus infections. Previous studies using gene-deficient mice have revealed that neither IFNγ nor perforin is essential in controlling the outcome of infection or the virus load duri...

journal_title：Scandinavian journal of immunology

authors： Bartholdy C,Høgh-Petersen M,Storm P,Holst PJ,Orskov C,Christensen JP,Thomsen AR

更新日期：2014-06-01 00:00:00

abstract：:When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irr...

journal_title：Scandinavian journal of immunology

authors： Tauris P

更新日期：1983-09-01 00:00:00

abstract：:Tumour-draining lymph node T cells are an excellent source of effector T cells that can be used in adoptive tumour immunotherapy because they have already been sensitized to tumour-associated antigens in vivo. However, such tumour-specific immune cells are not readily obtained from the host due to poor immunogenicity ...

journal_title：Scandinavian journal of immunology

authors： Ishida A,Tanaka H,Hiura T,Miura S,Watanabe S,Matsuyama K,Kuriyama H,Tanaka J,Kagamu H,Gejyo F,Yoshizawa H

更新日期：2007-11-01 00:00:00

abstract：:Culture filtrate from Mycobacterium tuberculosis contains protective molecules which have been used successfully in experimental vaccines against tuberculosis. Despite an increasing number of mycobacterial proteins being characterised, a major effort is still needed to get an overview of the many potentially interesti...

journal_title：Scandinavian journal of immunology

authors： Weldingh K,Hansen A,Jacobsen S,Andersen P

更新日期：2000-01-01 00:00:00

abstract：:This paper briefly reviews commonly used procedures for separation of mononuclear cells (MNC) and granulocytes from human blood with X-ray contrast media as gradient material, and also presents new and modified procedures for leucocyte preparation. Standard techniques for human blood do not always yield satisfactory r...

journal_title：Scandinavian journal of immunology

authors： Bøyum A,Løvhaug D,Tresland L,Nordlie EM

更新日期：1991-12-01 00:00:00

abstract：:In a previous report the authors demonstrated that acute graft-versus-host disease (GVHD) was associated with pathologic amounts of tumour necrosis factor alpha (TNF-alpha) and the appearance of lipopolysaccharide (LPS) in the blood of GVH reactive mice just prior to death. In this study the authors have investigated ...

journal_title：Scandinavian journal of immunology

authors： Price KS,Nestel FP,Lapp WS

更新日期：1997-03-01 00:00:00

abstract：:22q11.2 deletion syndrome is the commonest chromosome deletion syndrome. 22q11.2 deletion may result in variable clinical phenotypes which may differ even between patients with identical deletions. Abnormal pharyngeal arch development results in defects in the development of the parathyroid glands, thymus and conotrun...

journal_title：Scandinavian journal of immunology

authors： McLean-Tooke A,Spickett GP,Gennery AR

更新日期：2007-07-01 00:00:00