Plaque-forming cells in man. II. Evidence of the existence of active suppressor cells in peripheral blood of normal plaque-forming cell non-responders.

Abstract:

:When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irradiation on normal PFC responders and non-responders was also investigated; 2000-rad-irradiated non-responder T lymphocytes co-cultured with autologous untreated B lymphocytes restored the PFC response to normal levels. The evidence of a high level of suppressor activity in non-responder T lymphocytes was further demonstrated by the decreased PFC response of normal B lymphocytes co-cultured with untreated non-responder T lymphocytes.

journal_name

Scand J Immunol

authors

Tauris P

doi

10.1111/j.1365-3083.1983.tb00864.x

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

249-53

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

18

pub_type

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