Abstract:
:When the immunoglobulin secretion of 172 normal healthy individuals was investigated with the protein-A plaque assay, 12 persons (7%) did not develop any plaque-forming cells (PFC) in cultures of pokeweed mitogen (PWM)-activated unfractionated peripheral blood lymphocytes (PBL), incubated for 6 days. The effect of irradiation on normal PFC responders and non-responders was also investigated; 2000-rad-irradiated non-responder T lymphocytes co-cultured with autologous untreated B lymphocytes restored the PFC response to normal levels. The evidence of a high level of suppressor activity in non-responder T lymphocytes was further demonstrated by the decreased PFC response of normal B lymphocytes co-cultured with untreated non-responder T lymphocytes.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Tauris Pdoi
10.1111/j.1365-3083.1983.tb00864.xsubject
Has Abstractpub_date
1983-09-01 00:00:00pages
249-53issue
3eissn
0300-9475issn
1365-3083journal_volume
18pub_type
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