Characterization of stimulatory surface molecular expression on avian T cells.

abstract：:The CD45 molecule is a transmembrane tyrosine phosphatase that may be associated with the T-cell receptor (TCR). This has led to the suggestion that CD45 may be important for the regulation of signal transduction in T cells. This idea is supported by the finding that antibodies against CD45 are comitogenic in prolifer...

journal_title：Scandinavian journal of immunology

authors： Wolff H,Janeway C Jr

更新日期：1994-07-01 00:00:00

abstract：:There is an increasing need for novel biomarkers that enable better diagnostic and prognostic stratification of patients with suspected infection. A proprotein convertase enzyme FURIN is upregulated upon immune cell activation, and it promotes infectivity by cleaving and activating pathogens. In this study, we determi...

journal_title：Scandinavian journal of immunology

authors： Ranta N,Turpeinen H,Oksanen A,Hämäläinen S,Huttunen R,Uusitalo-Seppälä R,Rintala E,Aittoniemi J,Pesu M

更新日期：2015-12-01 00:00:00

abstract：:Osteoclasts are responsible for bone destruction in rheumatoid arthritis (RA), and adipose-derived mesenchymal stromal cells (ADSCs) can inhibit experimental collagen-induced arthritis model. This study aims to determine whether ADSCs also suppresses osteoclastogenesis and bone erosion in collagen-induced arthritis (C...

journal_title：Scandinavian journal of immunology

authors： Chang Q,Li C,Lu Y,Geng R,Wei JN,Hu JZ

更新日期：2020-08-01 00:00:00

abstract：:The current critical shortage of human donor organs has stimulated the feasibility of the xenogenic transplantation, such as swine to primate. We have previously reported the induction of donor-specific tolerance in MHC-disparated recipient mice by using our cyclophosphamide (CP)-induced tolerance conditioning. In thi...

journal_title：Scandinavian journal of immunology

authors： Tomita Y,Shimizu I,Iwai T,Zhang QW,Okano S,Kajiwara T,Onzuka T,Tominaga R

更新日期：2006-10-01 00:00:00

abstract：:The immune system produces specific antibodies (Ab) against any antigens (Ag) of exogenous and endogenous origins with a diverse repertoire of V-region specificities. The primary V-region repertoire is created by the rearrangement of immunoglobulin (Ig) V-region, D- and J-segments with the insertion of N- and P-sequen...

journal_title：Scandinavian journal of immunology

authors： Sakaguchi N,Maeda K,Kuwahara K

更新日期：2011-06-01 00:00:00

abstract：:Haematopoietic precursors first colonizing the avian embryonic thymus are derived from the intraembryonic sites located around the dorsal aortae. These intraembryonic precursors have previously been demonstrated to include cells that harbour T-cell progenitor capacity and express the Ikaros transcription factor, known...

journal_title：Scandinavian journal of immunology

authors： Liippo J,Koskela K,Lassila O

更新日期：2000-11-01 00:00:00

abstract：:Bone marrow cells from two patients without detectable monoclonal immunoglobulin (Ig) in serum and urine but with the clinical picture of plasma cell myeloma were cultivated in vitro. Immunofluorescence studies of cultured living and fixed bone marrow cells showed no signs of Ig production in one of the cases, whereas...

journal_title：Scandinavian journal of immunology

authors： Nilsson K,Killander D,Killander J,Mellstedt H

更新日期：1976-01-01 00:00:00

abstract：:Sensitization of B10.A mice with oxazolone results in delayed-type hypersensitivity (DTH) and a two to three-fold increase in the weight of regional lymph nodes by the third day. Hydrocortisone treatment of the animals 3 days after sensitization suppresses the manifestation of DTH on the tenth day but not on the seven...

journal_title：Scandinavian journal of immunology

authors： Venetianer A,Arányi P,Bösze ZS,Fachet J

更新日期：1978-01-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBM) from four patients with IgG myeloma and four patients with benign monoclonal gammopathy (BMG) were stimulated with pokeweed mitogen (PWM), and the in vitro immunoglobulin production over 7 days was measured with an enzyme-linked immunosorbent assay. All myeloma patients were su...

journal_title：Scandinavian journal of immunology

authors： Peest D,Brunkhorst U,Schedel I,Deicher H

更新日期：1984-02-01 00:00:00

abstract：:Phosphorothioate oligodeoxynucleotides (sODNs) can induce T-cell-independent polyclonal activation of human B cells by a mechanism that depends on both sequence and back-bone structure. Because matrix-bound as well as soluble sODNs are mitogenic, this stimulation may result from the engagement of surface receptor(s). ...

journal_title：Scandinavian journal of immunology

authors： Liang H,Reich CF,Pisetsky DS,Lipsky PE

更新日期：2001-12-01 00:00:00

abstract：:Immunisation of female mice with the allergen ovalbumin (OVA) during pregnancy reduces the OVA-specific IgE response in adult offspring. To approach primary prevention strategies for allergy, we investigated to what extent genetic, paternal and maternal factors influence this suppressive effect on allergic sensitisati...

journal_title：Scandinavian journal of immunology

authors： Nygaard UC,Hansen JS,Groeng EC,Melkild I,Løvik M

更新日期：2013-02-01 00:00:00

abstract：:Cellular immune response and delayed-type hypersensitivity reactions are considered to play a major role in the immunopathogenesis of pulmonary tuberculosis (PTB). But the exact mechanism is still to be clarified. Th1 cells are mainly involved in cellular immune responses in PTB and provide a normal healing process wi...

journal_title：Scandinavian journal of immunology

authors： Aktas E,Ciftci F,Bilgic S,Sezer O,Bozkanat E,Deniz O,Citici U,Deniz G

更新日期：2009-09-01 00:00:00

abstract：:Administration of D-penicillamine (50 mg/kg/day orally) to rats with adjuvant arthritis for up to 42 days significantly modified the incorporation of 3H-thymidine (3H-TdR) in concanavalin A (Con A)-stimulated lymph node cells. Treatment with D-penicillamine abolished the ability of macrophages from arthritic rats to i...

journal_title：Scandinavian journal of immunology

authors： Binderup L,Bramm E,Arrigoni-Martelli E

更新日期：1980-01-01 00:00:00

abstract：:We previously raised a rabbit antiserum (L12) against a 38 kD polypeptide which is expressed on the surface of thymocytes and peripheral T cells of an Urodele Amphibian, the Mexican axolotl (Ambystoma mexicanum). Here we show that L12 antibodies immunoprecipitate several labelled molecules from surface iodinated axolo...

journal_title：Scandinavian journal of immunology

authors： Kerfourn F,Guillet F,Charlemagne J,Tournefier A

更新日期：1993-10-01 00:00:00

abstract：:Phagocytes, such as granulocytes and monocytes/macrophages, contain a membrane-associated NADPH oxidase that produces superoxide leading to other reactive oxygen species with microbicidal, tumoricidal and inflammatory activities. Primary defects in oxidase activity in chronic granulomatous disease (CGD) lead to severe...

journal_title：Scandinavian journal of immunology

authors： de Oliveira-Junior EB,Bustamante J,Newburger PE,Condino-Neto A

更新日期：2011-05-01 00:00:00

abstract：:Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely un...

journal_title：Scandinavian journal of immunology

authors： Popovic M,Ahlqvist E,Rockenbauer E,Bockermann R,Holmdahl R

更新日期：2008-10-01 00:00:00

abstract：:Immunoglobulin G (IgG) is important in clearance and recognition of previously presented antigens and after activation, IgGs can interact with the Fc gamma receptors (FcγRs) on haematopoietic cells, including bone-resorbing osteoclasts. The pathogenicity of IgG, that is the ability to elicit stimulatory effects via Fc...

journal_title：Scandinavian journal of immunology

authors： Sehic E,Westerlund A,Lagerquist MK,Lerner UH,Carlsten H,Henning P,Engdahl C

更新日期：2020-12-15 00:00:00

abstract：:Spleens from newborn mice less than 6-7 days of age contain 'naturally occurring' suppressor cell populations that are able to inhibit nonspecifically immune responses of third-party adult spleen cells and alloreactivity in the newborn spleen per se. Isolation of the effectors of this suppressor activity reveals that ...

journal_title：Scandinavian journal of immunology

authors： Peeler K,Wigzell H,Peck AB

更新日期：1983-05-01 00:00:00

abstract：:Antibodies to DNA (anti-DNA) play an important role in the pathogenesis of systemic lupus erythematosus (SLE). In blood, these antibodies may exist in a free, unbound state or as part of complexes with DNA. Furthermore, circulating DNA may be either complexed or free. Because of the central role of these immunoreactan...

journal_title：Scandinavian journal of immunology

authors： Björkman L,Reich CF,Pisetsky DS

更新日期：2003-06-01 00:00:00

abstract：:Plasma and serum samples from a patient with homozygous C2 deficiency and severe systemic lupus erythematosus who responded with full clinical remission after plasma infusions were examined for immune complexes (IC), C3 activation products, and the terminal complement complex (TCC). Plasma contained large amounts of C...

journal_title：Scandinavian journal of immunology

authors： Garred P,Mollnes TE,Thorsteinsson L,Erlendsson K,Steinsson K

更新日期：1990-01-01 00:00:00

abstract：:The immune response of adult BALB/c mice against the bacterial antigen dextran B1355S (Dex) is well characterized as thymus independent (TI type 2) and Igha linked. The antisera consist of mainly IgM/lambda antibodies directed against the alpha(1-->3) glucosidic linkage. This study describes the immune response agains...

journal_title：Scandinavian journal of immunology

authors： Willers J,Weiler E,Kolb C

更新日期：1995-09-01 00:00:00

abstract：:TNF-alpha production has a central role in the development and progression of Pseudomonas aeruginosa septic shock. We have previously shown that P. aeruginosa slime-glycolipoprotein (slime-GLP) is the most potent stimulant compared to P. aeruginosa lipopolysaccharide (LPS), for TNF-alpha production and NF-kB activatio...

journal_title：Scandinavian journal of immunology

authors： Lagoumintzis G,Xaplanteri P,Dimitracopoulos G,Paliogianni F

更新日期：2008-02-01 00:00:00

abstract：:Central events in the host defence system and immune-mediated damage are tightly regulated by cell adhesion molecules. Sera from 28 human immunodeficiency virus (HIV)-1 infected children divided into groups according to disease severity, six seroreverting (SR) children and 25 healthy controls were studied to detect th...

journal_title：Scandinavian journal of immunology

authors： Gaddi E,Laucella S,Balbaryski J,Cantisano C,Barboni G,Candi M,Giraudi V

更新日期：2000-12-01 00:00:00

abstract：:Several enveloped viruses, particularly some RNA viruses, have high rates of mutation or replication, which can make them virulent pathogens in humans and other mammals. A proposed treatment could use synthesized proteins to mask pathogenic viral surface proteins to quickly induce an immune attack on specific envelope...

journal_title：Scandinavian journal of immunology

authors： Roe K

更新日期：2020-09-01 00:00:00

abstract：:Cells of the mononuclear phagocytic system (MPS) were described as playing a decisive role in amyloidogenesis. A relationship between the amyloid enhancing factor (AEF) and MPS cells was suggested and recently AEF activity was attributed to a serine esterase (SE) of leucocytic origin. In the present study, no correlat...

journal_title：Scandinavian journal of immunology

authors： Niewold TA,Gruys E,Kisilevsky R,Shirahama TS

更新日期：1991-07-01 00:00:00

abstract：:This study describes Leishmania antigen-induced activation of lymphocytes isolated from Kenyan donors, previously treated for visceral leishmaniasis, and from Danish and Kenyan controls. Peripheral blood mononuclear cells (PBMC) from cured Kala-Azar patients proliferated and produced Interferon-gamma in vitro in respo...

journal_title：Scandinavian journal of immunology

authors： Kemp M,Theander TG,Handman E,Hey AS,Kurtzhals JA,Hviid L,Sørensen AL,Were JO,Koech DK,Kharazmi A

更新日期：1991-02-01 00:00:00

abstract：:Proteins secreted by Mycobacterium tuberculosis are targets of host immune responses and as such are investigated for vaccine and immunodiagnostics development. Computer-driven searches of the M. tuberculosis H37Rv genome had previously identified 45 novel secreted proteins. Here, we report the characterization of the...

journal_title：Scandinavian journal of immunology

authors： Ben Amor Y,Shashkina E,Johnson S,Bifani PJ,Kurepina N,Kreiswirth B,Bhattacharya S,Spencer J,Rendon A,Catanzaro A,Gennaro ML

更新日期：2005-02-01 00:00:00

abstract：:L929, 3T12-3, B16, 3LL, and YAC1 cells with cytostatic factor (CF)-inducing activity from Lactobacillus casei-elicited murine peritoneal macrophages (LCEPM) were susceptible to the cytostatic activity of LCEPM and to LCEPM-produced CF, but L1210, P388D1, and Colon 26 cells, which have no CF-inducing activity, were res...

journal_title：Scandinavian journal of immunology

authors： Hashimoto S,Nagaoka M,Yokokura T,Mutai M

更新日期：1988-03-01 00:00:00

abstract：:Peripheral blood lymphoid subsets expressing either CD45RA or CD29 antigens, were quantified in 30 children and 59 adults with Down Syndrome and appropriate age-matched controls, by dual immunofluorescence and flow cytometry. Down's patients, both adults and children, displayed a significant decrease of CD4+CD45RA+ ce...

journal_title：Scandinavian journal of immunology

authors： Barrena MJ,Echaniz P,Garcia-Serrano C,Cuadrado E

更新日期：1993-10-01 00:00:00

abstract：:Antibodies forming a complex with antigen in vivo can dramatically change the antibody response to this antigen. In some situations, the response will be a 100-fold stronger than in animals immunized with antigen alone, and in other situations, the response will be completely suppressed. IgG is known to suppress the a...

journal_title：Scandinavian journal of immunology

authors： Xu H,Heyman B

更新日期：2020-10-01 00:00:00