Increased amounts of C4-containing immune complexes and inefficient activation of C3 and the terminal complement pathway in a patient with homozygous C2 deficiency and systemic lupus erythematosus.

abstract：:Beta-2 microglobulin (beta 2m) gene 'knock-out' mice (C1D) were primed with purified H-2Kb and H-2Db molecules and spleen cells from immunized mice were used to generate monoclonal antibody secreting B-cell hybridomas. Approximately 0.2% of the Ig-secreting primary microcultures contained H-2b binding antibodies. Thre...

journal_title：Scandinavian journal of immunology

authors： Claesson MH,Endel B,Ulrik J,Pedersen LO,Skov S,Buus S

更新日期：1994-08-01 00:00:00

abstract：:Three strains of mice bearing the autosomal recessive lpr gene (MRL, C57BL/6, and C3H) that had spontaneously developed a lupus-like disease were studied sequentially for functional natural killer (NK) and natural cytotoxic (NC) cell activity. Natural killing was impaired in spleen and bone marrow cells from all the l...

journal_title：Scandinavian journal of immunology

authors： Pan LZ,Dauphinée MJ,Ansar Ahmed S,Talal N

更新日期：1986-04-01 00:00:00

abstract：:The aim of this study was to evaluate possible changes in the circulating levels of interferon (IFN)-gamma, interleukin (IL)-4 and transforming growth factor (TGF)-beta in association with the autoimmune process leading to type 1 diabetes. Expression levels of mRNAs specific for each cytokine were determined in periph...

journal_title：Scandinavian journal of immunology

authors： Halminen M,Simell O,Knip M,Ilonen J

更新日期：2001-05-01 00:00:00

abstract：:RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches (PP). To understand the cellular interactions underlying lymphoproliferation further, the authors investigated the fa...

journal_title：Scandinavian journal of immunology

authors： Colombi S,Moutschen M,de Leval L,Demoitié MA,Trebak M,Martin MT,Boniver J

更新日期：1997-02-01 00:00:00

abstract：:Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children req...

journal_title：Scandinavian journal of immunology

authors： Karnabi E,Boutjdir M

更新日期：2010-09-01 00:00:00

abstract：:The development of B-cell lymphomas is an intricate interplay among various pathogenic factors, leading to a multi-step process, encompassing various stages of B-cell maturation. Besides genetic abnormalities, a variety of environmental and microbial factors, as well as disproportional immune-regulatory processes lead...

journal_title：Scandinavian journal of immunology

authors： Illes A,Varoczy L,Papp G,Wilson PC,Alex P,Jonsson R,Kovacs T,Konttinen YT,Zeher M,Nakken B,Szodoray P

更新日期：2009-05-01 00:00:00

abstract：:The advent of advanced molecular biological techniques in the last two decades has allowed the study of genetic factors in inflammatory bowel disease (IBD). A variety of techniques have been employed to elucidate the effects of genes, starting with the clinical observations that IBD is more common in the relatives of ...

journal_title：Scandinavian journal of immunology

authors： Orchard TR,Satsangi J,Van Heel D,Jewell DP

更新日期：2000-01-01 00:00:00

abstract：:Antigen 60 (A60), a member of the thermostable macromolecular antigen family (TMA) and main component of old tuberculin and purified protein derivative (PPD), has been purified from the cytoplasm of Mycobacterium bovis BCG; its structure and metabolism have already been described. In the present paper, the action of A...

journal_title：Scandinavian journal of immunology

authors： Cocito C,Baelden MC,Benoit C

更新日期：1987-06-01 00:00:00

abstract：:Physical association was measured between MLV gp70, the envelope glycoprotein of Rauscher murine leukaemia virus (R-MLV), and serologically defined H-2 antigens on the surface of R-MLV transformed C57BL/6 (H-2DbKb) mouse leukaemia cells (RBL-5A). Capping and patching with antisera against H-2Db caused specific co-capp...

journal_title：Scandinavian journal of immunology

authors： Zarling DA,Keshet I,Watson A,Bach FH

更新日期：1978-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects and the underlying mechanisms of fentanyl anaesthetic on T lymphocytes isolated from human umbilical cord blood in vitro. The percentages of CD4+ , CD8+ and regulatory T (Treg) cells in human umbilical cord blood mononuclear cells (UBMC) treated with fentanyl in vit...

journal_title：Scandinavian journal of immunology

authors： Ma K,Ma P,Lu H,Liu S,Cao Q

更新日期：2017-05-01 00:00:00

abstract：:Some data suggest that the interaction between CD28 and CD80 (B7.1) stimulates Th1-responses and that CD28 and CD86 (B7.2) stimulates Th2-responses, however this is controversial. We addressed this issue by using mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats as a highly polarized Th2 model a...

journal_title：Scandinavian journal of immunology

authors： MacPhee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2001-11-01 00:00:00

abstract：:Natural killer (NK) cells represent the first line of defence against viral infections but, in the case of hepatitis B virus (HBV), may also be involved in liver injury. We here compared NK-cell activity of 11 patients with acute HBV infection, either HIV-positive or HIV-negative, with that of 11 healthy subjects. One...

journal_title：Scandinavian journal of immunology

authors： Morsica G,Tasca S,Biswas P,Galli A,Malnati M,Paties C,Marinelli M,Bagaglio S,Lazzarin A,Fortis C

更新日期：2005-09-01 00:00:00

abstract：:Denaturing high-performance liquid chromatography (DHPLC) was evaluated as a tool for diagnostic screening of polymorphisms in the tumour necrosis factor receptor superfamily member 6 (TNFRSF6) also known as CD95, Apo-1 or Fas gene. Exons 1-9 of the TNFRSF6 gene were amplified from genomic DNA of 38 individuals, of wh...

journal_title：Scandinavian journal of immunology

authors： Etokebe GE,Abrahamsen TG,Bogen B,Spurkland A

更新日期：2004-05-01 00:00:00

abstract：:In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...

journal_title：Scandinavian journal of immunology

authors： Alenmyr L,Matheu V,Uller L,Greiff L,Malm-Erjefält M,Ljunggren HG,Persson CG,Korsgren M

更新日期：2005-11-01 00:00:00

abstract：:Prognosis in myelodysplastic syndrome (MDS) is not only correlated closely with blast cell count in bone marrow and chromosomal abnormalities but also correlated with decreased leucocyte count and function leading to acquisition of lethal infections. Recently, clinical trials in MDS have focused on the application of ...

journal_title：Scandinavian journal of immunology

authors： Zwierzina H,Holzinger I,Gaggl S,Wolf H,Schöllenberger S,Lam C,Bammer T,Geissler D,Lindley I

更新日期：1993-03-01 00:00:00

abstract：:The demonstration in the 1960s that T cells collaborated with B cells in enabling antibody responses to simple protein antigens opened up the challenge of how to investigate the interactions of two rare antigen-specific lymphocytes within a vast population. One idea was that T cells made soluble factors that could act...

journal_title：Scandinavian journal of immunology

authors： Waldmann H

更新日期：2005-07-01 00:00:00

abstract：:Fresh human T lymphocytes from the blood of healthy individuals exhibited few motile forms, i.e. nonspherical shape and lamellar surface activity, when allowed to settle on a plastic surface. This poor motility of 'normal' blood T lymphocytes is most likely physiological, since under the same conditions more than 75% ...

journal_title：Scandinavian journal of immunology

authors： Sundqvist KG,Otteskog P,Mellstedt H

更新日期：1986-06-01 00:00:00

abstract：:The restriction fragment length polymorphism of the human tumour necrosis factor (TNF alpha) region was investigated by means of 20 different restriction enzymes and a human TNF alpha cDNA probe. Only one of the enzymes, NcoI, revealed a polymorphic pattern consisting of fragments of 10.5 and 5.5 kb, which behaved as ...

journal_title：Scandinavian journal of immunology

authors： Fugger L,Morling N,Ryder LP,Platz P,Georgsen J,Jakobsen BK,Svejgaard A,Dalhoff K,Ranek L

更新日期：1989-08-01 00:00:00

abstract：:The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tum...

journal_title：Scandinavian journal of immunology

authors： Warren HS,Lafferty KJ

更新日期：1979-01-01 00:00:00

abstract：:Paratuberculosis (Johne's disease) is a chronic enteritis syndrome of ruminants, which is due to infection by Mycobacterium paratuberculosis. Cutaneous testing with proteins extracted from a mycobacterial culture fluid (johnin-PPD) is currently used to evaluate the cellular immune status. We have compared the componen...

journal_title：Scandinavian journal of immunology

authors： Gilot P,De Kesel M,Coene M,Cocito C

更新日期：1992-12-01 00:00:00

abstract：:Neural transplantation may become an important treatment alternative for focal brain disorders. To date, the most successful grafts have been obtained in patients with Parkinson's disease. Completely normalized dopamine production and reduction of Parkinsonian symptoms have been demonstrated 10 years after grafting. H...

journal_title：Scandinavian journal of immunology

authors： Larsson LC,Widner H

更新日期：2000-09-01 00:00:00

abstract：:An idiotypic network model of AIDS pathogenesis is described in which the T cell receptor plays a role both in infection and as a target of autoimmunity. This is an extension of a previously published autoimmunity model, and provides explanations for several otherwise puzzling aspects of AIDS pathogenesis. In the mode...

journal_title：Scandinavian journal of immunology

authors： Hoffmann GW

更新日期：1995-04-01 00:00:00

abstract：:Monoclonal anti-HLA-DR antibodies inhibited the production of interleukin-2 (IL-2) when added from the initiation of autologous (AMLR) and allogeneic (MLR) mixed lymphocyte reactions, but not 60 h later. The inhibitory activity of the anti-DR sera became apparent 8 h after initiation of the cultures and was maintained...

journal_title：Scandinavian journal of immunology

authors： Palacios R

更新日期：1981-09-01 00:00:00

abstract：:CD172α and CD47 are members of glycoprotein expressed on macrophages and various immune cells, promote immune recognition and T cell stimulation that priming phagocytosis of pathogens and apoptotic bodies and malignant cell. Tumour-releasing immunosuppressive factor promotes tumour growth and transforms the tumour res...

journal_title：Scandinavian journal of immunology

authors： Gautam PK,Acharya A

更新日期：2014-07-01 00:00:00

abstract：:In the present study, T-cell subsets from aged individuals were examined by using anti-BAT (brain-associated thymocyte antigen) serum. Anti-BAT serum was raised against the human fetal brain at 28 weeks of gestation. After absorption wit AB erythrocytes, B-cell lines, and leukaemic cells, anti-BAT serum was T cell-spe...

journal_title：Scandinavian journal of immunology

authors： Abe T,Morimoto C,Toguchi T,Kiyotaki M,Homma M

更新日期：1981-01-01 00:00:00

abstract：:Interleukin-12 receptor deficiency is a well-described cause of human susceptibility to infection with low-virulent mycobacteria and Salmonella species. We identified a male patient presenting in his late forties with severe gastroenteropathy because of outbred infestation by a previously unknown mycobacterium. In add...

journal_title：Scandinavian journal of immunology

authors： Schejbel L,Rasmussen EM,Kemp HB,Lundstedt AC,Nielsen KR,Obel N,Marquart H,Andersen AB

更新日期：2011-12-01 00:00:00

abstract：:To investigate the influence of genetic and/or environmental factors in the development and shaping of the human peripheral T cell repertoire the authors studied the T-cell receptor (TCR) V beta usage in 10 adult monozygous (Mz) and nine dizygous (Dz) twin pairs living in a Plasmodium falciparum endemic area in West A...

journal_title：Scandinavian journal of immunology

authors： Troye-Blomberg M,Fogdell A,el-Ghazali G,Larsson A,King MH,Sisay-Joof F,Olerup O,Grunewald J,Jepson A

更新日期：1997-05-01 00:00:00

abstract：:After intravenous injection of 10(5) purified, lymph node (LN)-derived dm2 (H-2d/Ld-) CD4+ T cells into young C.B-17 scid/scid (severe combined immunodeficiency, SCID) mice (H-2d/Ld+), the transplanted Ld-T cells show a selective pattern of engraftment: they repopulate the spleen, the lamina propria of the small intes...

journal_title：Scandinavian journal of immunology

authors： Rudolphi A,Enssle KH,Claesson MH,Reimann J

更新日期：1993-07-01 00:00:00

abstract：:With the aim of investigating the distribution of T cells expressing different T-cell receptors (TCR) in the inflamed synovial tissue of rheumatoid arthritis patients, we have used the polymerase chain reaction to amplify TCR V alpha and V beta transcripts from synovial biopsies obtained by arthroscopy from patients w...

journal_title：Scandinavian journal of immunology

authors： Bucht A,Oksenberg JR,Lindblad S,Grönberg A,Steinman L,Klareskog L

更新日期：1992-02-01 00:00:00

abstract：:We examined the effects of CD86 ligation on surface densities of CD80 on activated B cells. For this, splenic B cells where CD86 levels had been enhanced upon anti-immunoglobulin M (IgM) treatment were employed. Incubation of such CD86-expressing B cells with anti-CD86 monoclonal antibody (MoAb) resulted in a marked u...

journal_title：Scandinavian journal of immunology

authors： Sahoo NC,Rao KV,Natarajan K

更新日期：2002-06-01 00:00:00