The T cell receptor and AIDS pathogenesis.

Abstract:

:An idiotypic network model of AIDS pathogenesis is described in which the T cell receptor plays a role both in infection and as a target of autoimmunity. This is an extension of a previously published autoimmunity model, and provides explanations for several otherwise puzzling aspects of AIDS pathogenesis. In the model HIV-specific T cells are preferentially infected, and HIV, acting as an antigen, stimulates the expansion of the infectable pool of T cells. The HIV variants that are most strongly selected are those that are recognized by the most helper T cells. HIV and suppressor T cells are subject to the same selective environment, and consequently undergo a process of convergent selection to resemble each other more and more with time. Eventually immunity against HIV cross-reacts with suppressor T cell idiotypes, disrupting the normal regulation of helper T cells. Autoimmunity ensues. The model leads to novel vaccine and therapy approaches involving the targeting and elimination of HIV-specific T cells.

journal_name

Scand J Immunol

authors

Hoffmann GW

doi

10.1111/j.1365-3083.1995.tb03575.x

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

331-7

issue

4

eissn

0300-9475

issn

1365-3083

journal_volume

41

pub_type

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