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Natural killer-cell cytotoxicity in HIV-positive and HIV-negative patients with and without severe course of hepatitis B virus infection.

Abstract：

:Natural killer (NK) cells represent the first line of defence against viral infections but, in the case of hepatitis B virus (HBV), may also be involved in liver injury. We here compared NK-cell activity of 11 patients with acute HBV infection, either HIV-positive or HIV-negative, with that of 11 healthy subjects. One of the HIV-positive patients, characterized by a severe immunodeficiency, died 3 weeks after hospitalization for HBV-related fulminant hepatitis (FH). He displayed a remarkable NK-cell cytotoxicity against both cell lines and autologous dendritic cells, whereas the NK-cell activity of the remaining patients was significantly reduced as compared with healthy individuals. Our findings suggest that NK-cell-mediated cytotoxicity could contribute to the development of HBV-related acute liver failure in HIV-positive patients with severe immunodeficiency. An immunopathological model of FH in immunocompromised patients was proposed.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Morsica G,Tasca S,Biswas P,Galli A,Malnati M,Paties C,Marinelli M,Bagaglio S,Lazzarin A,Fortis C

doi

10.1111/j.1365-3083.2005.01659.x

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

318-24

issue

3

eissn

0300-9475

issn

1365-3083

pii

SJI1659

journal_volume

62

pub_type

杂志文章

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