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Accessory cell-dependent T-cell activation via Ti-CD3. Involvement of CD2-LFA-3 interactions.

Abstract：

:The activation of resting T cells to interleukin 2 (IL-2) production and DNA synthesis via Ti-CD3 is dependent on accessory cells (AC). Using positively selected, resting T cells activated with particle-bound anti-CD3, we investigated the ability of various cell lines to function as AC. We found that cell lines able to act as AC all expressed LFA-3, while cell lines not expressing LFA-3 were unable to provide AC signals. This applied to CD3+, CD4+, and CD8+ T cells. Sheep red blood cells (SRBC), which express LFA-3-like molecules, also had a weak, but significant AC function in this test system. Both CD4+ and CD8+ T cells activated with particle-bound anti-CD3 could be induced to enter DNA synthesis in the absence of AC when monoclonal antibodies reacting with CD2 were present instead of AC. IL-2 production could be detected in the latter cultures but not when positively selected CD3+ or CD2+ T cells were cultured alone. Our data suggest that activation of resting T cells via CD3 will lead to IL-2 receptor expression, while the interactions between LFA-3 and its ligand CD2 provide the necessary secondary signals for IL-2 production and induction of DNA synthesis.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

doi

10.1111/j.1365-3083.1988.tb01449.x

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

277-84

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

28

pub_type

杂志文章

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