Transformation of amyloid precursor SAA to protein AA and incorporation in amyloid fibrils in vivo.

abstract：:In the absence of an affordable conjugate meningococcal vaccine, mass vaccination campaigns with polysaccharide vaccines are the means to control meningitis epidemics in sub-Saharan Africa. Facing global vaccine shortage, the use of reduced doses, which have been shown to be protective by serum bactericidal activity, ...

journal_title：Scandinavian journal of immunology

authors： Bårnes GK,Naess LM,Rosenqvist E,Guerin PJ,Caugant DA,Fractional Doses Vaccine Study Group.

更新日期：2011-07-01 00:00:00

abstract：:A serum amyloid A (SAA) clone was isolated from a Tammar wallaby cDNA library, the most distantly related mammalian species for which an SAA has been described to date. The clone predicts a premolecule of 127 amino acids with good homology to other mammalian SAAs, and consists of an 18 residue leader peptide and a mat...

journal_title：Scandinavian journal of immunology

authors： Uhlar CM,Black IL,Shields DC,Brack CM,Schreiber G,Whitehead AS

更新日期：1996-03-01 00:00:00

abstract：:The lectin pathway (LP) of the complement system may initiate inflammatory reactions when body tissue is altered. We aimed to investigate levels of the LP proteins in out-of-hospital cardiac arrest patients, and to compare these with healthy individuals. Furthermore, we aimed to clarify whether duration of targeted te...

journal_title：Scandinavian journal of immunology

authors： Haugaard SF,Jeppesen AN,Troldborg A,Kirkegaard H,Thiel S,Hvas AM

更新日期：2018-06-09 00:00:00

abstract：:Oral vaccination with the combined B subunit/whole cell cholera vaccine generates antitoxin memory cells that could be isolated from peripheral blood for at least 1 year after immunization. These memory cells were triggered by antigen in vitro to produce antitoxin in the presence of autologous T cells and monocytes. A...

journal_title：Scandinavian journal of immunology

authors： Lycke N,Hellström U,Holmgren J

更新日期：1987-08-01 00:00:00

abstract：:Beta 2-microglobulin (beta 2m) constitutes the common light chain of both the MHC-encoded HLA-ABC molecules and a group of structurally related glycoproteins recognized by antibodies of the first cluster of differentiation (CD1a, CD1b and CD1c). These CD1 antigens appear similar to murine T1 and Qa molecules in terms ...

journal_title：Scandinavian journal of immunology

authors： Jones RA,Child JA,Master PS,Scott CS

更新日期：1991-07-01 00:00:00

abstract：:Administration of D-penicillamine (50 mg/kg/day orally) to rats with adjuvant arthritis for up to 42 days significantly modified the incorporation of 3H-thymidine (3H-TdR) in concanavalin A (Con A)-stimulated lymph node cells. Treatment with D-penicillamine abolished the ability of macrophages from arthritic rats to i...

journal_title：Scandinavian journal of immunology

authors： Binderup L,Bramm E,Arrigoni-Martelli E

更新日期：1980-01-01 00:00:00

abstract：:The oral commensal bacterium Streptococcus gordonii has been gathering interest as a candidate live mucosal vaccine delivery vector. S. gordonii has been shown to be capable of activating antigen presenting immune cells in a manner which leads to their activation and maturation, yet the mechanism used by S. gordonii t...

journal_title：Scandinavian journal of immunology

authors： Mayer ML,Phillips CM,Townsend RA,Halperin SA,Lee SF

更新日期：2009-04-01 00:00:00

abstract：:The epidermis has been identified as an important site for the initiation of immunological events. In addition to the macrophage-like Langerhans cells, keratinocytes within the epidermal cells have been shown to act as immunoregulatory cells through the secretion of cytokines such as epidermal cell-derived thymocyte-a...

journal_title：Scandinavian journal of immunology

authors： Luger TA,Köck A,Danner M

更新日期：1985-05-01 00:00:00

abstract：:Increased serum immunoglobulin A (IgA) level is a common finding in primary Sjögren's syndrome (pSS). IgA might not be properly eliminated because of an abnormal glycosylation. We reported previously that IgA1 from patients with pSS was oversialylated. We extend this finding by showing that monomeric IgA1 contains mor...

journal_title：Scandinavian journal of immunology

authors： Basset C,Durand V,Jamin C,Clément J,Pennec Y,Youinou P,Dueymes M,Roitt IM

更新日期：2000-03-01 00:00:00

abstract：:In the present study evidence is presented that SAA in serum complexes to a carrier protein with a molecular weight of 100,000-200,000 daltons, with mobility in the alpha-region on electrophoresis, and with a rather low normal serum concentration. The carrier protein is apparently not albumin. SAA isolated from the ca...

journal_title：Scandinavian journal of immunology

authors： Skogen B,Natvig JB,Michaelsen TE,Anders RF

更新日期：1977-01-01 00:00:00

abstract：:The expression and function of neural cell adhesion molecule (NCAM, CD56, Leu19) on leukaemic blasts was investigated. The expression of NCAM was frequent (64%) in 14 studied cases of acute myeloid leukaemia (AML) but not in chronic lymphocytic leukaemia (CLL: 1/3 cases positive) or immunocytoma (IC: no positivity). N...

journal_title：Scandinavian journal of immunology

authors： Palucka AK,Porwit A,Reizenstein P

更新日期：1992-04-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies (AFA) in patients with SSc. The clinical features of 3...

journal_title：Scandinavian journal of immunology

authors： Tall F,Dechomet M,Riviere S,Cottin V,Ballot E,Tiev KP,Montin R,Morin C,Chantran Y,Grange C,Jullien D,Ninet J,Chretien P,Cabane J,Fabien N,Johanet C

更新日期：2017-01-01 00:00:00

abstract：:In 10 blood samples from mothers who were studied after the delivery of a male infant and who had Y-body-containing cells in their circulations (mean value, 0.06%) the proportions of surface-Ig- and Y-body-positive lymphocytes were determined after passage through nylon wool. In each case one part of the sample was tr...

journal_title：Scandinavian journal of immunology

authors： Schröder J

更新日期：1975-01-01 00:00:00

abstract：:Immunohistological techniques were used to identify activated T lymphocytes within the synovial membrane of patients with rheumatoid arthritis, using the monoclonal antibody (MoAb) RFT2, which identifies a 40-k dalton molecule preferentially expressed by T blasts or activated cells. Using this reagent together with a ...

journal_title：Scandinavian journal of immunology

authors： Poulter LW,Duke O,Panayi GS,Hobbs S,Raftery MJ,Janossy G

更新日期：1985-12-01 00:00:00

abstract：:Previous work from our laboratory demonstrated that a synthetic heptapeptide (Ch7: RGSDIAG), corresponding to a conserved sequence of human immunodeficiency virus (HIV) core protein p24 (amino acids 232- 238), was able to specifically abrogate antigen-induced responses in cultures of normal human peripheral blood mono...

journal_title：Scandinavian journal of immunology

authors： Giacomini E,Chersi A,Giordani L,Luzzati AL

更新日期：2000-02-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBM) from four patients with IgG myeloma and four patients with benign monoclonal gammopathy (BMG) were stimulated with pokeweed mitogen (PWM), and the in vitro immunoglobulin production over 7 days was measured with an enzyme-linked immunosorbent assay. All myeloma patients were su...

journal_title：Scandinavian journal of immunology

authors： Peest D,Brunkhorst U,Schedel I,Deicher H

更新日期：1984-02-01 00:00:00

abstract：:Blood levels of regulators of the complement system in preterm babies were reported in few studies only. The aim of this study was to set up a complement profile in premature and term babies focusing on the development of blood levels of MBL, key regulatory proteins and on classical pathway activity, which may allow a...

journal_title：Scandinavian journal of immunology

authors： Grumach AS,Ceccon ME,Rutz R,Fertig A,Kirschfink M

更新日期：2014-04-01 00:00:00

abstract：:The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primar...

journal_title：Scandinavian journal of immunology

authors： Carvalho LJ,Oliveira SG,Theisen M,Alves FA,Andrade MC,Zanini GM,Brígido MC,Oeuvray C,Póvoa MM,Muniz JA,Druilhe P,Daniel-Ribeiro CT

更新日期：2004-04-01 00:00:00

abstract：:Interactions between homing receptors on circulating leucocytes and endothelial addressins regulate tissue-specific cellular extravasation. Although integrin alpha 4 beta 7 appears to be the main receptor for gut-homing T lymphocytes, less is known about molecules mediating mucosal B cell homing. Expression of integri...

journal_title：Scandinavian journal of immunology

authors： Farstad IN,Halstensen TS,Lazarovits AI,Norstein J,Fausa O,Brandtzaeg P

更新日期：1995-12-01 00:00:00

abstract：:Antigen-binding peripheral blood leukocytes (PBL) from normal and bursectomized agammaglobulinemic chickens were labeled by incubation in vitro with radioiodinated antigen at 4 degrees C in the presence of sodium azide. [125I]TGAL-binding cells could be detected by autoradiography of PBL from normal, unimmunized chick...

journal_title：Scandinavian journal of immunology

authors： Jensenius C,Crone M,Koch C

更新日期：1975-01-01 00:00:00

abstract：:Atrial fibrillation is highly prevalent, and affected patients are at an increased risk of a number of complications, including heart failure and thrombo-embolism. Over the past years, there has been increasing interest in the role of inflammatory processes in atrial fibrillation, from the first occurrence of the arrh...

journal_title：Scandinavian journal of immunology

authors： Lappegård KT,Hovland A,Pop GA,Mollnes TE

更新日期：2013-08-01 00:00:00

abstract：:The mixed lymphocyte culture (MLC) response of lymphocytes from CBA mice against C3H cells was studied after injection of spleen cells from C3H mice or C3H hybrids. Intravenous infusion of C3H cells resulted in a strongly suppressed specific MLC response, but this was not the case when cells from H-2-incompatible hybr...

journal_title：Scandinavian journal of immunology

authors： Lilliehöök B,Jacobsson H,Blomgren H

更新日期：1975-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects and the underlying mechanisms of fentanyl anaesthetic on T lymphocytes isolated from human umbilical cord blood in vitro. The percentages of CD4+ , CD8+ and regulatory T (Treg) cells in human umbilical cord blood mononuclear cells (UBMC) treated with fentanyl in vit...

journal_title：Scandinavian journal of immunology

authors： Ma K,Ma P,Lu H,Liu S,Cao Q

更新日期：2017-05-01 00:00:00

abstract：:Our objective was to investigate the patterns of proliferation and differentiation of infiltrating cells in inflammatory myopathies. Immunohistochemical staining was performed on muscle biopsy specimens from 18 patients with inclusion body myositis, polymyositis and dermatomyositis using monoclonal and polyclonal anti...

journal_title：Scandinavian journal of immunology

authors： Lindberg C,Oldfors A,Tarkowski A

更新日期：1995-05-01 00:00:00

abstract：:Allergic airway disorders such as asthma and allergic rhinitis are mainly caused by inhaled allergen-induced improper activation and responses of immune and non-immune cells. One important response is the production of IL-27 by macrophages and dendritic cells (DCs) during the early stage of airway allergies. IL-27 exe...

journal_title：Scandinavian journal of immunology

authors： Jafarzadeh A,Nemati M,Jafarzadeh S,Chauhan P,Saha B

更新日期：2021-02-01 00:00:00

abstract：:We have investigated the ability of different cells from non-immunized mice of the BALB/c strain to present antigen to two ovalbumin-specific I-Ad-restricted T hybridomas. Lipopolysaccharide-activated B-cell blasts were found to be the most efficient antigen-presenting cells. Purified small and dense splenic B cells a...

journal_title：Scandinavian journal of immunology

authors： Gontijo CM,Möller G

更新日期：1991-08-01 00:00:00

abstract：:Peripheral CD4 T-cell depletion has been observed in human immunodeficiency virus (HIV)-negative patients with pulmonary tuberculosis (TB). To investigate more accurately this alteration, we studied peripheral blood CD45RA(+) and CD29(high) CD4 subsets in 79 TB patients with (HIV(+)TB(+)) or without (HIV(-)TB(+)) HIV ...

journal_title：Scandinavian journal of immunology

authors： Diagbouga S,Chiron JP,Sanou O,Ledru E

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms by which glucocorticoids suppress immune responses have not yet been clearly defined. In steroid-sensitive pathological conditions, an increase in gamma delta T cells can occur in certain untreated systemic autoimmune disorders and seems to be a peristent feature in most cases of systemic lupus erythema...

journal_title：Scandinavian journal of immunology

authors： Spinozzi F,Agea E,Bistoni O,Travetti A,Migliorati G,Moraca R,Nicoletti I,Riccardi C,Paoletti FP,Vaccaro R

更新日期：1995-05-01 00:00:00

abstract：:Conditions for the cloning of alloactivated human lymphocytes by limiting dilution in the presence of interleukin 2 (IL 2) and filler cells have been investigated. Cloning efficiencies were extremely high (at least 40%) when IL 2 derived from pooled peripheral blood mononuclear cells (PBM), stimulated with phytohaemag...

journal_title：Scandinavian journal of immunology

authors： Kahle P,Wernet P,Rehbein A,Kumbier I,Pawelec G

更新日期：1981-11-01 00:00:00

abstract：:(NZB x NZW)F1 (B/W) mice spontaneously develop a disease which is remarkably similar to systemic lupus erythematosus (SLE) in humans. This disease is characterized by the appearance of autoantibodies to double-stranded (ds)DNA and the subsequent development of fatal glomerulonephritis. The prophylactic treatment of B/...

journal_title：Scandinavian journal of immunology

authors： Lin RH,Wang LF

更新日期：1994-05-01 00:00:00