Circulating cholera antitoxin memory cells in the blood one year after oral cholera vaccination in humans.

Abstract:

:Oral vaccination with the combined B subunit/whole cell cholera vaccine generates antitoxin memory cells that could be isolated from peripheral blood for at least 1 year after immunization. These memory cells were triggered by antigen in vitro to produce antitoxin in the presence of autologous T cells and monocytes. Antitoxin-producing peripheral blood lymphocytes (PBL) were found in 4 out of 5 previously vaccinated subjects. IgA and IgM isotypes dominated the memory response. The antigen-dose dependency and requirements for a specific ratio of T to B cells for activation of the memory cells in vitro implies T-cell control of antitoxin responses. These antitoxin memory cells in peripheral blood (and corresponding antibacterial memory cells) might represent a pool of circulating cells that on renewed exposure to cholera rapidly produce protective antibody in the gut and thus might have a central role in the long-term protection against reinfection and disease seen in convalescents from cholera.

journal_name

Scand J Immunol

authors

Lycke N,Hellström U,Holmgren J

doi

10.1111/j.1365-3083.1987.tb02253.x

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

207-11

issue

2

eissn

0300-9475

issn

1365-3083

journal_volume

26

pub_type

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