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Compartment dependence of T-lymphocyte motility.

Abstract：

:Fresh human T lymphocytes from the blood of healthy individuals exhibited few motile forms, i.e. nonspherical shape and lamellar surface activity, when allowed to settle on a plastic surface. This poor motility of 'normal' blood T lymphocytes is most likely physiological, since under the same conditions more than 75% of the blood lymphocytes from T-cell chronic lymphocytic leukaemia (TCLL) cases showed motile forms. In contrast to blood T cells, a large proportion of fresh human splenic T lymphocytes from separate individuals generally showed motile behaviour within 1 h when plated on a substrate. The rate of migration of spleen T cells into a collagen matrix was higher than that of blood T cells. The poor motile behaviour therefore appeared to be a limiting factor for translocation and migration of blood T cells within a collagen matrix. Culture on a collagen matrix at 'low' cell density in the presence or absence of serum for 2 days augmented the percentage of motile blood T cells to the same level as for fresh spleen T cells, whereas culture on plastic caused a relatively moderate increase in motility. This collagen-mediated potentiation probably does not reflect polyclonal T-cell activation, since it occurred in serum-free medium and appeared independent of cell interactions, and since collagen did not induce DNA synthesis. These results demonstrate two major factors regulating the 'spontaneous' motility of T lymphocytes, namely the location of the cell within the body and the nature of the substratum.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Sundqvist KG,Otteskog P,Mellstedt H

doi

10.1111/j.1365-3083.1986.tb02000.x

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

647-54

issue

6

eissn

0300-9475

issn

1365-3083

journal_volume

23

pub_type

杂志文章

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