Progression of articular destruction and the production of tumour necrosis factor-alpha in antigen-induced arthritis in rabbits.

abstract：:RNA silencing is an efficient biochemical tool for gene knock downs as well as physiological phenomenon playing a major role in diverse biological processes. Recent knowledge suggests that the same protein families which mediate the experimental RNA interference (RNAi) in the fruit fly Drosophila melanogaster cells al...

journal_title：Scandinavian journal of immunology

authors： Ulvila J,Hultmark D,Rämet M

更新日期：2010-03-01 00:00:00

abstract：:Neutrophils are essential for the host defence against infection. However, neutrophils may also mediate damage namely during immune mediated pathologies. We therefore tested whether targeting of different cell adhesion molecules with specific monoclonal antibodies might reduce immune mediated neutrophil recruitment bu...

journal_title：Scandinavian journal of immunology

authors： Gonçalves AS,Appelberg R

更新日期：2000-05-01 00:00:00

abstract：:Antigen-specific lymphocyte hybridomas have been produced by a simple in vitro immunization procedure. Non-immune spleen cells have been activated in vitro, and the B-cell blasts have subsequently been used for somatic cell hybridization. Hybrids secreting monoclonal antibodies to human myoglobin, pig insulin, and ben...

journal_title：Scandinavian journal of immunology

authors： Borrebaeck CA

更新日期：1983-07-01 00:00:00

abstract：:We have sequenced the variable heavy chain regions of a number of VH4-21 encoded monoclonal IgM anti-Rh(D) antibodies produced in response to deliberate immunization. These were compared with the sequences of similarly encoded IgM anti-I cold agglutinins (CA) derived from patients with lympho-proliferative diseases. T...

journal_title：Scandinavian journal of immunology

authors： Børretzen M,Chapman C,Stevenson FK,Natvig JB,Thompson KM

更新日期：1995-07-01 00:00:00

abstract：:There is strong evidence from animal models that placental and/or breast milk-mediated transfer of maternal allergen-specific IgG prevents allergic immune responses in the progeny. Both human and animal data also point to IgA as having an important regulatory role. In contrast, little is known about maternal transfer ...

journal_title：Scandinavian journal of immunology

authors： Macchiaverni P,Arslanian C,Frazão JB,Palmeira P,Russo M,Verhasselt V,Condino-Neto A

更新日期：2011-12-01 00:00:00

abstract：:Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. T helper (Th) 17 cells, which play a detrimental role in experimental murine models of inflammatory diseases, have been demonstrated to participate in the pathogenesis of liver damage. The inhibitory effect of halofuginone (H...

journal_title：Scandinavian journal of immunology

authors： Liang J,Zhang B,Shen RW,Liu JB,Gao MH,Geng X,Li Y,Li YY,Zhang W

更新日期：2014-03-01 00:00:00

abstract：:Chromosomally marked cells from the 7-day intraembryonic mesenchyme were transplanted into 14-day-old irradiated chick embryos. At the age of 6 weeks donor-derived T and B lymphocytes were shown to be present in the thymus, spleen and bone marrow, indicating that cells in the 7-day intraembryonic mesenchyme are capabl...

journal_title：Scandinavian journal of immunology

authors： Lassila O,Eskola J,Toivanen P,Dieterlen-Lièvre F

更新日期：1980-01-01 00:00:00

abstract：:The therapeutic use of the immune system to specifically attack tumours has been a long-standing vision among tumour immunologists. Recently, the use of checkpoint inhibitors to turn-off immunosuppressive signals has proven to be effective in enhancing T-cell reactivity against patient-specific neoantigens, resulting ...

journal_title：Scandinavian journal of immunology

authors： Sioud M

更新日期：2018-03-01 00:00:00

abstract：:In the context of ex vivo T cell elimination from bone marrow, the anti-T cell cytotoxic potential of immunotoxins (IT) prepared by conjugation of the monoclonal antibodies (MoAb) WT32 (CD3), T101 (CD5), and WT1 (CD7) to ricin A chain was evaluated. The cytotoxicity of IT was based on protein synthesis inhibition in h...

journal_title：Scandinavian journal of immunology

authors： Preijers FW,Tax WJ,Wessels JM,Capel PJ,De Witte T,Haanen C

更新日期：1988-05-01 00:00:00

abstract：:In the present study we describe the production and characterization of a panel of monoclonal antibodies (MoAbs) directed against cruzipain (Crz), the major cysteine proteinase from Trypanosoma cruzi. The five MoAbs, BD6, BF2, CG2, CH8, and DC10 were analysed with respect to affinity and specificity. None of the MoAbs...

journal_title：Scandinavian journal of immunology

authors： Gonzalez G,Orn A,Cazzulo JJ,Grönvik KO

更新日期：1994-10-01 00:00:00

abstract：:Myeloid dendritic cells (MyDCs), prime stimulators of antigen-specific immunity, can serve as one of the major reservoirs for human immunodeficiency virus type-1 (HIV-1). Utilizing mature monocyte-derived MyDCs generated with granulocyte/macrophage colony-stimulating factor, interleukin-4, and tumour necrosis factor-a...

journal_title：Scandinavian journal of immunology

authors： Gieseler RK,Marquitan G,Hahn MJ,Perdon LA,Driessen WH,Sullivan SM,Scolaro MJ

更新日期：2004-05-01 00:00:00

abstract：:Immunotherapy using dendritic cells (DC) has shown promising results. However, the use of an appropriate DC population is critical for the outcome of this treatment, and the search for an optimal DC subset is still ongoing. The DC used in immunotherapy today are usually matured with a cytokine cocktail consisting of T...

journal_title：Scandinavian journal of immunology

authors： Karlsen M,Hovden AO,Vogelsang P,Tysnes BB,Appel S

更新日期：2011-08-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that exercise would induce inflammatory response characterized by increased pro-inflammatory cytokines - interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), adhesion molecule, matrix metalloprotease-9 (MMP-9) and myeloperoxidase (MPO) levels. Additional aim was t...

journal_title：Scandinavian journal of immunology

authors： Reihmane D,Jurka A,Tretjakovs P

更新日期：2012-08-01 00:00:00

abstract：:Coeliac disease (CD) is a very common food-sensitive enteropathy, which is triggered by gluten ingestion and is mediated by CD4(+) T cells. In addition, alterations in the intestinal microbiota that is normally involved in the homeostasis of GALT (gut-associated lymphoid tissue) seem to play a role in CD. In accordanc...

journal_title：Scandinavian journal of immunology

authors： D'Arienzo R,Stefanile R,Maurano F,Mazzarella G,Ricca E,Troncone R,Auricchio S,Rossi M

更新日期：2011-10-01 00:00:00

abstract：:The natural tolerance to alpha-fetoprotein (AFP) was broken in rabbits by immunizations with purified AFP from different species and homologous AFP chemically modified by haptenation. Some of the rabbits were boostered with rabbit AFP. The highest titers were obtained with human AFP, which shows a strong cross-reactio...

journal_title：Scandinavian journal of immunology

authors： Pihko H

更新日期：1976-01-01 00:00:00

abstract：:Propagermanium is an organic germanium compound with immunopotentiating activity. We examined the hepatoprotective effect of propagermanium and its mechanism in an experimental animal model of acute liver injury induced with Corynebacterium parvum (C. parvum) and lipopolysaccharide (LPS) injection. Oral pretreatment w...

journal_title：Scandinavian journal of immunology

authors： Yokochi S,Ishiwata Y,Hashimoto H,Ninomiya F,Suzuki T

更新日期：1998-08-01 00:00:00

abstract：:We have previously shown that various benign and malignant natural killer (NK)-resistant monolayer cells inhibit endogenous human NK activity, probably by reducing the secretion of cytotoxic factors from the effector cells. The nature of the molecules responsible for the inhibition has been unclear. In this study we s...

journal_title：Scandinavian journal of immunology

authors： Heiskala MK,Stenman UH,Koivunen E,Carpén O,Saksela E,Timonen T

更新日期：1988-07-01 00:00:00

abstract：:Discontinuous Percoll gradients have been used to obtain selected human peripheral blood T lymphocytes without having to resort to interactions with immune complexes in the fractionation of Tm, Tg and Ta cells. Here, we could show that Ta cells represent a heterogeneous population with no distinct density profile, in ...

journal_title：Scandinavian journal of immunology

authors： Canonica GW,Kabelitz D,Sjöberg O,Aigrain Y,Wigzell H

更新日期：1982-09-01 00:00:00

abstract：:The role of several adhesion molecules for lymphocyte-endothelial interactions in the synovia of rheumatoid arthritis patients was studied using the frozen section assay. Partial inhibition of lymphocyte binding to endothelium of synovial sections could be observed with antibodies against CD44, L-selectin, and beta 1-...

journal_title：Scandinavian journal of immunology

authors： Fischer C,Thiele HG,Hamann A

更新日期：1993-08-01 00:00:00

abstract：:An immunization protocol that induces antibodies (Abs) directed to cryptic epitopes of a protein antigen (Ag) reduces the efficacy of vaccines that ideally should induce Abs against native epitopes. We have shown earlier that viral infections concomitant with immunization against a protein tend to shift the Ab specifi...

journal_title：Scandinavian journal of immunology

authors： Gómez KA,Longhi SA,Marino VJ,Mathieu PA,Loureiro ME,Coutelier JP,Roguin LP,Retegui LA

更新日期：2003-02-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBM) from four patients with IgG myeloma and four patients with benign monoclonal gammopathy (BMG) were stimulated with pokeweed mitogen (PWM), and the in vitro immunoglobulin production over 7 days was measured with an enzyme-linked immunosorbent assay. All myeloma patients were su...

journal_title：Scandinavian journal of immunology

authors： Peest D,Brunkhorst U,Schedel I,Deicher H

更新日期：1984-02-01 00:00:00

abstract：:Mouse macrophages were cultured on chemically modified plastic dishes. On dishes covered with immobilized glycans, the macrophages were stimulated as judged by increased 14C-glucosamine incorporation, increased cytostatic and cytolytic capacities and by morphology as seen by scanning electron microscopy. The correspon...

journal_title：Scandinavian journal of immunology

authors： Bøgwald J,Gouda I,Hoffman J,Larm O,Larsson R,Seljelid R

更新日期：1984-10-01 00:00:00

abstract：:During the assembly of the HLA class I molecules with peptides in the peptide-loading complex, a series of transient interactions are made with ER-resident chaperones. These interactions culminate in the trafficking of the HLA class I molecules to the cell surface and presentation of peptides to CD8(+) T lymphocytes. ...

journal_title：Scandinavian journal of immunology

authors： Cabrera CM

更新日期：2007-06-01 00:00:00

abstract：:The T-cell regulatory function has been evaluated in lines of mice genetically selected according to the High (H) and Low (L) antibody responsiveness to heterologous erythrocytes. The inhibition of antibody production following CD4+ subset depletion was stronger in L than in H mice. The dose of CD4-specific monoclonal...

journal_title：Scandinavian journal of immunology

authors： Cabrera WH,Siqueira M,Takahashi NS,Ribeiro OG,Araujo LM,Mouton D,Ibanez OM

更新日期：1995-03-01 00:00:00

abstract：:A computer search was carried out for homologies between HLA-A and HLA-B antigen sequences and the sequences of constant and variable regions of immunoglobulins and of all other sequenced proteins. Searches were made both with relatively short peptide sequences from the HLA antigens and with those longer peptide seque...

journal_title：Scandinavian journal of immunology

authors： Strominger JL,Orr HT,Parham P,Ploegh HL,Mann DL,Bilofsky H,Saroff HA,Wu TT,Kabat EA

更新日期：1980-01-01 00:00:00

abstract：:TNF-alpha production has a central role in the development and progression of Pseudomonas aeruginosa septic shock. We have previously shown that P. aeruginosa slime-glycolipoprotein (slime-GLP) is the most potent stimulant compared to P. aeruginosa lipopolysaccharide (LPS), for TNF-alpha production and NF-kB activatio...

journal_title：Scandinavian journal of immunology

authors： Lagoumintzis G,Xaplanteri P,Dimitracopoulos G,Paliogianni F

更新日期：2008-02-01 00:00:00

abstract：:The T-cell repertoire is shaped by the positive and negative selection of immature CD4(+) CD8(+) double positive (DP) thymocytes. Positive selection of DP T cells to the CD4(+) CD8(-) and CD4(-) CD8(+) simple positive (SP) lineages is a multistep process which involves cellular interactions between thymocytes and stro...

journal_title：Scandinavian journal of immunology

authors： Nepomnaschy I,Lombardi G,Bekinschtein P,Berguer P,Francisco V,de Almeida J,Buggiano V,Pasqualini CD,Piazzon I

更新日期：2000-12-01 00:00:00

abstract：:The in vitro anti-trinitrophenyl (TNP) response induced by TNP-lipopolysaccharide (TNP-LPs) in mouse spleen cells was eliminated by passage through Sephadex G10 columns. Conditioned medium obtained from peritoneal macrophages restored the response, indicating the supportive role of such cells in the response. Converse...

journal_title：Scandinavian journal of immunology

authors： Martinez-Alonso C,Bernabe RR,Diaz-Espada F

更新日期：1980-01-01 00:00:00

abstract：:The effects of cytoplasmic anti-neutrophil cytoplasm autoantibodies (C-ANCA) and perinuclear ANCA (P-ANCA) immunoglobulin G (IgG) on tissue factor (TF) activity using HL-60 cells in vitro were compared with those of medium, lipopolysaccharide (LPS) and control IgG. Cells were also incubated with both ANCA IgG and cont...

journal_title：Scandinavian journal of immunology

authors： Flores-Suárez LF,Nowack R,Yard BA,Dempfle CE,Van Der Woude FJ

更新日期：2003-01-01 00:00:00

abstract：:The main object of this study was to see whether or not chromatin constituents are present in cell membranes. The binding of antinuclear antibodies (ANA) to plasma membranes of leucocytes was studied by using autoantibodies and induced antibodies to different histones and histone peptides, and autoantibodies to double...

journal_title：Scandinavian journal of immunology

authors： Rekvig OP

更新日期：1989-01-01 00:00:00