Different macrophage requirement in the specific and polyclonal responses induced by TNP-LPS and LPS.

abstract：:Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies (AFA) in patients with SSc. The clinical features of 3...

journal_title：Scandinavian journal of immunology

authors： Tall F,Dechomet M,Riviere S,Cottin V,Ballot E,Tiev KP,Montin R,Morin C,Chantran Y,Grange C,Jullien D,Ninet J,Chretien P,Cabane J,Fabien N,Johanet C

更新日期：2017-01-01 00:00:00

abstract：:Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signalling pathways within immune cells. Data from a haemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitory FcγR (CD32) suppresses the formation of antibody-secreting cells (...

journal_title：Scandinavian journal of immunology

authors： Vollack N,Friese J,Bergmann S,Cragg MS,Tiede A,Werwitzke S

更新日期：2017-08-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that leads to substantial suffering for millions of patients. In some patients, the chronic inflammation leads to remodelling of the extracellular matrix and fibrosis. Fibrosis, in combination with expansion of smooth muscle layers, l...

journal_title：Scandinavian journal of immunology

authors： Alfredsson J,Wick MJ

更新日期：2020-12-01 00:00:00

abstract：:Using cytotoxic effector cells of different anti-H-2 specificities, new cell-mediated lympholysis targets, normally undetected on Meth. A tumour cells, were shown after passage with vaccinia or Moloney virus. The H-2d CML targets on Meth. A cells recognized by B10.BR anti-B10.D2 effector cells were presented only afte...

journal_title：Scandinavian journal of immunology

authors： Matossian-Rogers A,Garrido F,Festenstein H

更新日期：1977-01-01 00:00:00

abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

journal_title：Scandinavian journal of immunology

authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

更新日期：1998-10-01 00:00:00

abstract：:The most frequent pathogen in haematogenously acquired kidney infections in humans in Staphylococcus aureus. In order to characterize in situ the immunological patterns of septic nephritis we developed a murine model of this disease. A single intravenous injection of S. aureus producing toxic shock syndrome toxin-1 re...

journal_title：Scandinavian journal of immunology

authors： Verba V,Tarkowski A

更新日期：1996-09-01 00:00:00

abstract：:Fresh human T lymphocytes from the blood of healthy individuals exhibited few motile forms, i.e. nonspherical shape and lamellar surface activity, when allowed to settle on a plastic surface. This poor motility of 'normal' blood T lymphocytes is most likely physiological, since under the same conditions more than 75% ...

journal_title：Scandinavian journal of immunology

authors： Sundqvist KG,Otteskog P,Mellstedt H

更新日期：1986-06-01 00:00:00

abstract：:The present study describes a 7 amino acid-long sequence (YQQQGRL) which is identical in HLA-associated invariant chain and mumps virus nucleocapsid protein and is additionally followed by one conservative amino acid pair. As such a long amino acid homology is extremely rare in two evolutionarily unrelated proteins th...

journal_title：Scandinavian journal of immunology

authors： Hyöty H,Parkkonen P,Rode M,Bakke O,Leinikki P

更新日期：1993-05-01 00:00:00

abstract：:Hypomorphic mutations in the gene encoding Bruton tyrosine kinase (BTK) may result in milder phenotypes and delayed diagnosis of B-cell related immunodeficiencies due to residual BTK function. Newborn screening for kappa-deleting-recombination-excision circles (KRECs) reliably identifies classical X-linked agammaglobu...

journal_title：Scandinavian journal of immunology

authors： Krüger R,Baumann U,Borte S,Kölsch U,Lorenz MR,Keller B,Harder I,Warnatz K,Ehl S,Schwarz K,Wahn V,von Bernuth H

更新日期：2020-01-01 00:00:00

abstract：:B-Lymphocyte-activating factor (BAFF/BLyS) is a survival factor for B cells, belonging to the tumor necrosis ligand super family. Serum BAFF levels have been found to be elevated in patients with systemic lupus erythematosus (SLE). Neutralization of BAFF activity was suggested as an additional therapeutic approach in ...

journal_title：Scandinavian journal of immunology

authors： Toubi E,Kessel A,Rosner I,Rozenbaum M,Paran D,Shoenfeld Y

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency. Although most people with selective IgAD (sIgAD) are asymptomatic, many patients often suffer from recurrent respiratory infections and different allergic disorders. Our aim was to investigate connection between subtypes of sIgAD...

journal_title：Scandinavian journal of immunology

authors： Živković J,Lipej M,Banić I,Bulat Lokas S,Nogalo B,Lulić Jurjević R,Turkalj M

更新日期：2019-12-01 00:00:00

abstract：:Age and gender-related variability of main lymphocyte subsets (T, B and NK cell absolute counts and percentages from Ly; T4, T8 and DN cell absolute counts and percentages from lymphocytes and from T cells; T4:T8 and T:B ratios) was studied in a large cohort of pediatric patients (2 days - 17 years) at yearly interval...

journal_title：Scandinavian journal of immunology

authors： Nikulshin S,Kundzina L,Tolstikova I,Gravele D,Prokofjeva T,Gardovska D

更新日期：2018-06-23 00:00:00

abstract：:As part of an ongoing project aimed at the characterization of the MHC system in bony fishes, we have attempted to identify the class III region in the zebrafish (a teleost), a region that in higher vertebrates contains genes coding for complement proteins C2, Bf and C4. We obtained several genomic PAC clones by hybri...

journal_title：Scandinavian journal of immunology

authors： Gongora R,Figueroa F,Klein J

更新日期：1998-12-01 00:00:00

abstract：:Immunoglobulin G (IgG) is important in clearance and recognition of previously presented antigens and after activation, IgGs can interact with the Fc gamma receptors (FcγRs) on haematopoietic cells, including bone-resorbing osteoclasts. The pathogenicity of IgG, that is the ability to elicit stimulatory effects via Fc...

journal_title：Scandinavian journal of immunology

authors： Sehic E,Westerlund A,Lagerquist MK,Lerner UH,Carlsten H,Henning P,Engdahl C

更新日期：2020-12-15 00:00:00

abstract：:The survival of T cells derived from the early waves of thymus colonization by haemopoietic cell precursors was investigated by grafting thymus from B6.Thy1.1 day 14 embryos (E14) (first wave) or E17 or newborn thymus (subsequent waves) into allogeneic athymic BALB/c (Thy1.2) nude recipients. The survival of donor-der...

journal_title：Scandinavian journal of immunology

authors： Thomas-Vaslin V,Salaün J,Coltey M,Vaigot P,Fucs R

更新日期：1997-05-01 00:00:00

abstract：:The authors have previously reported on the ability of A60, an immunodominant antigenic complex of Mycobacterium bovis BCG, to prevent cancer development in mice challenged with EMT 6 tumour cells. Such effect proved to rely on neoplastic cell lysis by cytolytic T lymphocytes and activated macrophages. The involvement...

journal_title：Scandinavian journal of immunology

authors： Maes H,Cocito C

更新日期：1996-10-01 00:00:00

abstract：:Peripheral blood monocyte (PBM) subsets play different roles in inflammatory response and tissue remodelling. The aim of this study was to investigate how allergen challenge affects the number of circulating PBMs in Dermatophagoides pteronyssinus (Dp) allergic patients (Dp-APs). Among 34 Dp-APs challenged, in 22 patie...

journal_title：Scandinavian journal of immunology

authors： Kowal K,Moniuszko M,Dabrowska M,Bodzenta-Lukaszyk A

更新日期：2012-05-01 00:00:00

abstract：:We have studied the binding of fibronectin to complement (C3b, C3bi, C3d)-coated agarose beads and its effect on cell association of such beads to mouse macrophages. Fibronectin bound to agarose beads preincubated in human serum, whereas no binding occurred after preincubation of the beads with complement-inactivated ...

journal_title：Scandinavian journal of immunology

authors： Johnson E,Gauperaa T,Eskeland T

更新日期：1985-09-01 00:00:00

abstract：:The monoclonal antibodies A and B specific for the HN molecule of Sendai virus were used to induce polyclonal and monoclonal anti-idiotypic antibodies. No response was observed in allogeneic Lewis rats, low responses in syngeneic LOU rats, and high responses in allogeneic BN rats and xenogeneic Balb/c mice. The monocl...

journal_title：Scandinavian journal of immunology

authors： Fenner M,Siegmann K,Binz H

更新日期：1986-09-01 00:00:00

abstract：:Colon cancer (CC) is one of the most common malignancies in the Western world. Although surgical resection is the first choice worldwide, at this point an effective approach for the treatment of patients with metastasis and cancer recurrence post-operation has not yet been found. The aim of this study was to investiga...

journal_title：Scandinavian journal of immunology

authors： Xu F,Ye YJ,Cui ZR,Wang S

更新日期：2005-04-01 00:00:00

abstract：:There is an increasing need for novel biomarkers that enable better diagnostic and prognostic stratification of patients with suspected infection. A proprotein convertase enzyme FURIN is upregulated upon immune cell activation, and it promotes infectivity by cleaving and activating pathogens. In this study, we determi...

journal_title：Scandinavian journal of immunology

authors： Ranta N,Turpeinen H,Oksanen A,Hämäläinen S,Huttunen R,Uusitalo-Seppälä R,Rintala E,Aittoniemi J,Pesu M

更新日期：2015-12-01 00:00:00

abstract：:Phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN) on the surface of endothelial cells is accompanied by adherence of the PMN to the endothelial surface and detachment of the endothelial cells from the culture monolayer. We studied the role of the leucocyte adherence-related glycoprotein...

journal_title：Scandinavian journal of immunology

authors： Vandenbroucke-Grauls CM,Thijssen HM,Tetteroo PA,Rozemuller E,Verhoef J

更新日期：1989-07-01 00:00:00

abstract：:The binding of 125I-labelled bovine serum albumin (BSA)-anti-BSA immune complexes (IC) to Raji cells and polymorphonuclear (PMN) cells in vitro was studied. The IC were reacted for 1 h at 37 degrees C with normal human serum (NHS) diluted 1:2 in the presence or absence of human erythrocytes (E) before presentation for...

journal_title：Scandinavian journal of immunology

authors： Rasmussen JM,Jepsen HH,Svehag SE

更新日期：1987-10-01 00:00:00

abstract：:Amyloid was extracted from the liver of a horse that had developed amyloidosis after being used for several years for the production of antibodies to bacterial antigens. The amyloid fibrils were shown to be of the AA type. Two AA proteins with molecular weights of 9000 and 11,000 and with identical partial N-terminal ...

journal_title：Scandinavian journal of immunology

authors： Husebekk A,Husby G,Sletten K,Marhaug G,Nordstoga K

更新日期：1986-06-01 00:00:00

abstract：:Natural killer (NK) cells represent the first line of defence against viral infections but, in the case of hepatitis B virus (HBV), may also be involved in liver injury. We here compared NK-cell activity of 11 patients with acute HBV infection, either HIV-positive or HIV-negative, with that of 11 healthy subjects. One...

journal_title：Scandinavian journal of immunology

authors： Morsica G,Tasca S,Biswas P,Galli A,Malnati M,Paties C,Marinelli M,Bagaglio S,Lazzarin A,Fortis C

更新日期：2005-09-01 00:00:00

abstract：:Basophilic granulocytes and mast cells of different species have been reported to originate from thymocytes and other lymphocytes. These observations were recently confirmed when evidence was given that thymic antigen is present on rabbit basophilic granulocytes. In the study reported here, human leukocytes were teste...

journal_title：Scandinavian journal of immunology

authors： Stallman PJ,Van Elven EH,Feltkamp-Vroom TM,Brutel de la Rivière A

更新日期：1977-01-01 00:00:00

abstract：:The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tum...

journal_title：Scandinavian journal of immunology

authors： Warren HS,Lafferty KJ

更新日期：1979-01-01 00:00:00

abstract：:Mice homologous for the alymphoplasia mutation (aly) show the systemic absence of secondary lymphoid tissues, with disorganized splenic architecture, including the absence of the germinal centre and follicular dendritic cells. In this study, we examined the influence of defects of gut-associated lymphoid tissue (GALT)...

journal_title：Scandinavian journal of immunology

authors： Morimoto M,Yamauchi Y,Shinkawa S,Ishiwata K,Hayashi T

更新日期：2006-05-01 00:00:00

abstract：:In a group of 20 patients with asymptomatic paraproteinemia, as judged after at least 3 years of follow-up, the primary and secondary antibody response to Helix pomatia hemocyanin (HPH) was defective as compared with the response in controls. The class of antibody was assessed by mercaptoethanol (ME) treatment of seru...

journal_title：Scandinavian journal of immunology

authors： Weits J,de Gast GC,The TH,Marrink J,Mandema E

更新日期：1976-01-01 00:00:00

abstract：:The procoagulant activities of non-elicited mouse monocytes/macrophages from four anatomical localizations were compared. These cell populations were further examined for their ability to increase their procoagulant activity on exposure to endotoxin or phytohaemagglutinin (PHA). Peritoneal macrophages exhibited the hi...

journal_title：Scandinavian journal of immunology

authors： Lyberg T,Amlie E,Kaplun A,Prydz H

更新日期：1983-09-01 00:00:00