Abstract:
:The survival of T cells derived from the early waves of thymus colonization by haemopoietic cell precursors was investigated by grafting thymus from B6.Thy1.1 day 14 embryos (E14) (first wave) or E17 or newborn thymus (subsequent waves) into allogeneic athymic BALB/c (Thy1.2) nude recipients. The survival of donor-derived Thy1.1 cells was longer when they were derived from early thymocytes. Donor B6.Thy1.1 V beta 5 and V beta 11 T cells, although maturing in BALB/c host presenting Mls2a superantigens, were not deleted, in contrast to host Thy1.2 T cells differentiating from endogenous stem cells. These results show that the population of T cells derived from early precursors undergoes particular selection characteristics, which favour the inclusion of potentially autoreactive cells with prolonged survival, even in H-2 allogeneic conditions which normally do not allow the survival of peripheral T cells.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Thomas-Vaslin V,Salaün J,Coltey M,Vaigot P,Fucs Rdoi
10.1046/j.1365-3083.1997.d01-424.xsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
482-6issue
5eissn
0300-9475issn
1365-3083journal_volume
45pub_type
杂志文章abstract::BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell development, with loss-of-function mutations causing X-linked agammaglobulinemia and susceptibility to severe, frequently lethal, Epstein-Barr virus infection, respectively. Over the last few years, considerable efforts have been made ...
journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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doi:10.1111/j.1365-3083.1975.tb02612.x
更新日期:1975-01-01 00:00:00
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journal_title:Scandinavian journal of immunology
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doi:10.1111/j.1365-3083.2006.01854.x
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1994.tb03428.x
更新日期:1994-07-01 00:00:00
abstract::The present study describes a 7 amino acid-long sequence (YQQQGRL) which is identical in HLA-associated invariant chain and mumps virus nucleocapsid protein and is additionally followed by one conservative amino acid pair. As such a long amino acid homology is extremely rare in two evolutionarily unrelated proteins th...
journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1995.tb03681.x
更新日期:1995-10-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章,评审
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1995.tb03709.x
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abstract::A Gross virus induced rat T cell lymphoma G1-Tc1 and a Moloney virus induced mouse T cell lymphoma YAC-1 are shown to exert a strong cytotoxic activity against rat yolk sac tumours but not to various types of rat, mouse or human normal cells or tumour cell lines including carcinomas, sarcomas, lymphomas and gliomas. B...
journal_title:Scandinavian journal of immunology
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更新日期:1997-11-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.2008.02103.x
更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
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doi:10.1046/j.1365-3083.1999.00544.x
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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doi:10.1046/j.1365-3083.2001.00853.x
更新日期:2001-02-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1995-05-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1994.tb03399.x
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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