Dysregulation of T helper cell cytokines in autoimmune prone NZB x NZW F1 mice.

abstract：:Peripheral blood monocyte (PBM) subsets play different roles in inflammatory response and tissue remodelling. The aim of this study was to investigate how allergen challenge affects the number of circulating PBMs in Dermatophagoides pteronyssinus (Dp) allergic patients (Dp-APs). Among 34 Dp-APs challenged, in 22 patie...

journal_title：Scandinavian journal of immunology

authors： Kowal K,Moniuszko M,Dabrowska M,Bodzenta-Lukaszyk A

更新日期：2012-05-01 00:00:00

abstract：:Assessment of cytokine expression has become crucial to understand host responses to infections as well as autoimmunity. Several approaches including Northern blot, RNase protection assay and enzyme-linked immunosorbent assay have been used for this purpose, but they are time consuming, labour intense, and relatively ...

journal_title：Scandinavian journal of immunology

authors： Ramos-Payán R,Aguilar-Medina M,Estrada-Parra S,González-Y-Merchand JA,Favila-Castillo L,Monroy-Ostria A,Estrada-Garcia IC

更新日期：2003-05-01 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that leads to substantial suffering for millions of patients. In some patients, the chronic inflammation leads to remodelling of the extracellular matrix and fibrosis. Fibrosis, in combination with expansion of smooth muscle layers, l...

journal_title：Scandinavian journal of immunology

authors： Alfredsson J,Wick MJ

更新日期：2020-12-01 00:00:00

abstract：:F protein is of unknown function and found principally in the liver, with smaller amounts detectable by gel diffusion and immunostaining in kidney and brain. By taking advantage of a newly developed radioimmunoassay, capable of detecting down to 1 ng ml-1 of F protein, the organ distribution of this molecule in the mo...

journal_title：Scandinavian journal of immunology

authors： Griffiths JA,Oliveira DB

更新日期：1988-03-01 00:00:00

abstract：:Human haptoglobin (Hp) is synthesized at hepatic and extrahepatic sites as an acute-phase reactant protein (APP). We investigated the effects of Hp on granulocyte function. The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was i...

journal_title：Scandinavian journal of immunology

authors： Rossbacher J,Wagner L,Pasternack MS

更新日期：1999-10-01 00:00:00

abstract：:Pretreatment with D-Penicillamine of rat peritoneal macrophages markedly influences their ability to modulate Concanavalin A stimulated [3H]thymidine incorporation in non-adherent rat lymph node cells. Untreated macrophages added in high numbers to the lymphocytes (ratio lymphocytes/macrophage 7.5 : 1) depress their [...

journal_title：Scandinavian journal of immunology

authors： Binderup L,Bramm E,Arrigoni-Martelli E

更新日期：1978-04-01 00:00:00

abstract：:Mitogen-induced cell-mediated cytotoxicity (MICC) of human peripheral blood granulocytes (PMN) and lymphocytes (PBL) was studied by using chicken erythrocytes as targets. The possible mechanisms were elicited bidirectionally by means of the MICC inhibition test and by functional analysis of lectin. In our preliminary ...

journal_title：Scandinavian journal of immunology

authors： Yue CL,Tanimoto K,Horiuchi Y

更新日期：1981-10-01 00:00:00

abstract：:Crude preparations of platelet-activating factors (PAF) derived by methanolic extraction of supernatants from antigen-challenged basophils generally stimulated the secretion of histamine from human peripheral blood leucocytes when co-incubated with these cells in the absence of an additional stimulator. When these cru...

journal_title：Scandinavian journal of immunology

authors： O'Donnell MC,Fiedel BA

更新日期：1981-01-01 00:00:00

abstract：:Many patients with inflammatory bowel disease (IBD) are undergoing therapy with infliximab, an antibody specific for TNF. However, the exact mechanisms of action of infliximab are not completely understood. The aim of this study was to determine the in vitro effects of infliximab on blood T cells derived from anti-TNF...

journal_title：Scandinavian journal of immunology

authors： Dahlén R,Strid H,Lundgren A,Isaksson S,Raghavan S,Magnusson MK,Simrén M,Sjövall H,Öhman L

更新日期：2013-09-01 00:00:00

abstract：:CD172α and CD47 are members of glycoprotein expressed on macrophages and various immune cells, promote immune recognition and T cell stimulation that priming phagocytosis of pathogens and apoptotic bodies and malignant cell. Tumour-releasing immunosuppressive factor promotes tumour growth and transforms the tumour res...

journal_title：Scandinavian journal of immunology

authors： Gautam PK,Acharya A

更新日期：2014-07-01 00:00:00

abstract：:T-cell sensitization to indirectly presented alloantigens (indirect pathway of allorecognition) plays a critical role in chronic rejection. The usual very efficient priming of such self-restricted, T helper type 1 (Th1)-deviated CD4+ T cells obviously conflicts with the fact that allogeneic MHC molecules are poorly im...

journal_title：Scandinavian journal of immunology

authors： Wallgren AC,Andersson B,Bäcker A,Karlsson-Parra A

更新日期：2005-09-01 00:00:00

abstract：:Sera genetically deficient in either the alpha-gamma or the beta-subunit of complement component C8 virtually lack haemolytic activity. We have studied the formation and the structural organization of the soluble terminal complement complex (TCC) assembled in these sera following activation with cobra venom factor (CV...

journal_title：Scandinavian journal of immunology

authors： Høgåsen K,Mollnes TE,Nürnberger W,Pausa M,Fukumori Y,Tedesco F

更新日期：1998-09-01 00:00:00

abstract：:We have examined the frequencies of T gamma delta cells in blood, synovial fluids, and synovial membranes of patients with rheumatoid arthritis (RA) and in blood from age-matched controls. Immunocytochemical and immunohistochemical techniques were used with monoclonal antibodies BB3 and A13 to define a major and minor...

journal_title：Scandinavian journal of immunology

authors： Smith MD,Bröker B,Moretta L,Ciccone E,Grossi CE,Edwards JC,Yüksel F,Colaco B,Worman C,Mackenzie L

更新日期：1990-12-01 00:00:00

abstract：:Tumour necrosis factor-α-induced protein-8 like-2 (TIPE2) is a newly identified immune negative regulator. The abnormal expression of TIPE2 has been found in several human inflammatory diseases. However, the expression level and clinical significance of TIPE2 in childhood asthma remain unclear. In this study, we detec...

journal_title：Scandinavian journal of immunology

authors： Ma Y,Liu X,Wei Z,Wang X,Wang Z,Zhong W,Li Y,Zhu F,Guo C,Zhang L,Wang X

更新日期：2013-12-01 00:00:00

abstract：:The epidermis has been identified as an important site for the initiation of immunological events. In addition to the macrophage-like Langerhans cells, keratinocytes within the epidermal cells have been shown to act as immunoregulatory cells through the secretion of cytokines such as epidermal cell-derived thymocyte-a...

journal_title：Scandinavian journal of immunology

authors： Luger TA,Köck A,Danner M

更新日期：1985-05-01 00:00:00

abstract：:We have previously reported that a cytosolic alkaline fraction (FI) obtained from epimastigotes of Trypanosoma cruzi promotes the activation, proliferation and differentiation of normal murine B cells into antibody-secreting plasmocytes. Neither the mechanism nor the cells involved in the FI-induced polyclonal B-cell ...

journal_title：Scandinavian journal of immunology

authors： Montes CL,Zuñiga E,Minoprio P,Vottero-Cima E,Gruppi A

更新日期：1999-08-01 00:00:00

abstract：:An antigen-specific T-cell line which transforms into T-lymphoma cells in vitro but apparently not in vivo is described. Membrane markers, tumorigenicity and T-cell receptor (TcR) V alpha and V beta-gene usage of the in vitro transformed T-cell line were analysed to investigate whether the transformation event was pol...

journal_title：Scandinavian journal of immunology

authors： Wegener AM,Holm B,Geisler C,Rubin B

更新日期：1990-05-01 00:00:00

abstract：:Here we analyse the ability of soluble immune complexes (IC) prepared with cationized antibodies to induce cytotoxic responses mediated by neutrophils. While cationized IC induced high levels of cytotoxicity, control IC induced very low levels of response. Inhibition of cytotoxicity by catalase but not by three haemen...

journal_title：Scandinavian journal of immunology

authors： Geffner JR,Trevani AS,Malchiodi E,Serebrinsky GP,Isturiz MA

更新日期：1993-02-01 00:00:00

abstract：:Chlamydia pneumoniae initiates infection in humans via the mucosal epithelia of the respiratory tract; therefore, immunity at this mucosal site is believed to be important to control infection with this pathogen. We compared the protective capacity of immunization in mice with two C. pneumoniae antigens, namely the ma...

journal_title：Scandinavian journal of immunology

authors： Rodríguez A,Rottenberg M,Tjärnlund A,Fernández C

更新日期：2006-03-01 00:00:00

abstract：:The predominant selection of CRI-A-bearing antibodies during the anti-arsonate (ARS) response of A/J mice has been used as a model to analyse the mechanism involved in the process of clonal selection and establishment of predominance. In order to assess the importance of the affinity and adaptability of CRI-A clones i...

journal_title：Scandinavian journal of immunology

authors： Gaya A,Alsinet E,Freixas M,Vives J

更新日期：1988-09-01 00:00:00

abstract：:With the aim of investigating the distribution of T cells expressing different T-cell receptors (TCR) in the inflamed synovial tissue of rheumatoid arthritis patients, we have used the polymerase chain reaction to amplify TCR V alpha and V beta transcripts from synovial biopsies obtained by arthroscopy from patients w...

journal_title：Scandinavian journal of immunology

authors： Bucht A,Oksenberg JR,Lindblad S,Grönberg A,Steinman L,Klareskog L

更新日期：1992-02-01 00:00:00

abstract：:IgE antibodies against trinitrophenylated ovalbumin (TNP-OVA) were raised in Brown Norway rats by a highly reproducible immunization procedure. With these rats, the kinetics of the IgE response was studied, both for free circulating and cell-bound IgE. Cell-bound IgE was dissociated from peritoneal cell suspensions at...

journal_title：Scandinavian journal of immunology

authors： van Toorenenbergen AW,van Swieten P,Aalberse RC

更新日期：1983-01-01 00:00:00

abstract：:Human peripheral lymphocytes were cultivated in soft agar or agarose, containing 3H-thymidine or bromodeoxyuridine (BrdU), which is an analogue of thymidine readily incorporated into deoxyribonucleic acid by lymphocytes. Colonies were isolated and analysed by autoradiography or stained with the fluorescence-plus-Giems...

journal_title：Scandinavian journal of immunology

authors： Lindahl-Kiessling K,Karlberg I

更新日期：1981-05-01 00:00:00

abstract：:The lymphocyte subsets in the bronchoalveolar lavage fluid (BALF) and the peripheral blood of 25 healthy volunteers were examined by analysis with a fluorescence-activated cell sorter. Comparison of the lymphocyte subsets in the BALF with those of the peripheral blood revealed much higher values for the ratios of each...

journal_title：Scandinavian journal of immunology

authors： Yamada M,Tamura N,Shirai T,Kira S

更新日期：1986-11-01 00:00:00

abstract：:RUTI is a vaccine consisting of Mycobacterium tuberculosis bacilli grown in stress conditions that is fragmented, detoxified and liposomed. RUTI was designed to shorten the treatment of latent tuberculosis infection (LTBI) with isoniazid from 9 months to just 1 month, by additional treatment with two inoculations of R...

journal_title：Scandinavian journal of immunology

authors： Vilaplana C,Ruiz-Manzano J,Gil O,Cuchillo F,Montané E,Singh M,Spallek R,Ausina V,Cardona PJ

更新日期：2008-06-01 00:00:00

abstract：:Tumour-draining lymph node T cells are an excellent source of effector T cells that can be used in adoptive tumour immunotherapy because they have already been sensitized to tumour-associated antigens in vivo. However, such tumour-specific immune cells are not readily obtained from the host due to poor immunogenicity ...

journal_title：Scandinavian journal of immunology

authors： Ishida A,Tanaka H,Hiura T,Miura S,Watanabe S,Matsuyama K,Kuriyama H,Tanaka J,Kagamu H,Gejyo F,Yoshizawa H

更新日期：2007-11-01 00:00:00

abstract：:A computer search was carried out for homologies between HLA-A and HLA-B antigen sequences and the sequences of constant and variable regions of immunoglobulins and of all other sequenced proteins. Searches were made both with relatively short peptide sequences from the HLA antigens and with those longer peptide seque...

journal_title：Scandinavian journal of immunology

authors： Strominger JL,Orr HT,Parham P,Ploegh HL,Mann DL,Bilofsky H,Saroff HA,Wu TT,Kabat EA

更新日期：1980-01-01 00:00:00

abstract：:Interleukin-17 (IL-17) plays an important role in several autoimmune diseases. IL-17 can induce the expression of vascular cell adhesion molecule (VCAM-1) in aortic vascular smooth muscle cells (SMCs), which is important for the development of atherosclerosis. However, the signalling pathway of IL-17-induced VCAM-1 ex...

journal_title：Scandinavian journal of immunology

authors： Zhang H,Chen J,Liu X,Awar L,McMickle A,Bai F,Nagarajan S,Yu S

更新日期：2013-04-01 00:00:00

abstract：:Direct contact between lymphokine-activated killer (LAK) cells and tumour cells is believed to be imperative for initiating tumour cell lysis in vitro as well as in vivo. In order to optimize adoptive immunotherapy (AIT) it is therefore desirable to identify the LAK cell subtype, which ensures maximal infiltration of ...

journal_title：Scandinavian journal of immunology

authors： Kjaergaard J,Hokland M,Nannmark U,Hokland P,Basse P

更新日期：1998-06-01 00:00:00

abstract：:A substantial proportion of immunologists, microbiologists and health professionals--and, indeed, many dictionaries--currently regard the term pathogen as a synonym for a pathogenic organism (most often a micro-organism). I will argue that this is a distortion of its original meaning--'a specific causative agent of di...

journal_title：Scandinavian journal of immunology

authors： Cunliffe J

更新日期：2008-08-01 00:00:00