Abstract:
:Secretagogin is a newly identified calcium-binding protein selectively expressed in neuroendocrine tissue and pancreatic beta-cells. The function of secretagogin is unknown, but it has been suggested in beta-cells to influence calcium-influx, insulin secretion and proliferation, and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. In the present study, we identified and characterized promoter activity of a human 1498 bp sequence upstream the transcription start site. The promoter sequence showed subtle but significant regulation by glucose within the normo-physiological range. Glucose also led to changes in expression of secretagogin protein in INS-1e cells, but not in primary cells from non-diabetes-prone Wistar Furth rats. No effects of cytokines neither on promoter activity nor protein expression were observed. The promoter region was furthermore screened by direct sequencing, and 11 polymorphisms were identified. Genotyping in a large homogenous Type 1 diabetes (T1D) family collection did not reveal association with T1D.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Skovhus KV,Bergholdt R,Erichsen C,Sparre T,Nerup J,Karlsen AE,Pociot Fdoi
10.1111/j.1365-3083.2006.01854.xsubject
Has Abstractpub_date
2006-12-01 00:00:00pages
639-45issue
6eissn
0300-9475issn
1365-3083pii
SJI1854journal_volume
64pub_type
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