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Amplification of T-cell and antibody responses in DNA-based immunization with HIV-1 Nef by co-injection with a GM-CSF expression vector.

Abstract：

:Intradermal inoculation of mice with naked plasmid DNA encoding the regulatory HIV-1 Nef protein was shown to induce Nef-specific T and B cell responses. Co-inoculation with an expression vector encoding murine granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine known to facilitate the induction of primary immune responses, resulted in a markedly enhanced response to Nef. This was manifested both as an increase in Nef-specific T cell responses and antibody levels. DNA immunization with the Nef and GM-CSF vectors induced primarily a Th1 response as judged by the raised levels of both IFN-gamma and IL-2 from re-stimulated T cells. The immunostimulatory activity of GM-CSF DNA was locally restricted and was observed only if both plasmid vectors were injected at the same site.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Svanholm C,Löwenadler B,Wigzell H

doi

10.1046/j.1365-3083.1997.d01-130.x

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

298-303

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

46

pub_type

杂志文章

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