Abstract:
:The expression of chemokines and chemokine receptors was studied in Leishmania donovani (LD)-infected human mononuclear phagocytes and the human monocytic cell line THP1. Our studies showed that LD infection caused the upregulation of three beta chemokines (macrophage inflammatory protein-1 alpha (MIP-1alpha), MIP-1beta and RANTES (regulated on activation normal T cell expressed and secreted)), one alpha chemokine (interleukin-8 (IL-8)) and the CC chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. The CCR5 upregulation in human mononuclear phagocytes and THP1 cells was also evident by confocal microscopy. The possible association of such upregulation in relation to Leishmania and human immunodeficiency virus (HIV) coinfection was discussed.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Dasgupta B,Roychoudhury K,Ganguly S,Akbar MA,Das P,Roy Sdoi
10.1046/j.1365-3083.2003.01227.xkeywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
366-74issue
4eissn
0300-9475issn
1365-3083pii
1227journal_volume
57pub_type
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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