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Distribution and characterization of autoantibodies to interleukin 1 alpha in normal human sera.

Abstract：

:Antibodies against IL-1 alpha were detected in sera of apparently healthy individuals. The immunoglobulins belonged to the IgG class, particularly IgG1, IgG2, and IgG4. [125I]rIL-1 alpha bound to Fab fragments of IgG, and IgG immune complexes of molecular weights from 160 to 700 kDa were formed in the sera by [125I]rIL-1 alpha. The occurrence of detectable anti-IL-1 alpha IgG in sera of 32 male and 32 female donors was 25 and 22% respectively. As judged by Scatchard analysis of the binding data, the capacity and avidity of binding were greater in the male than in the female sera (mean capacity to bind [125I]rIL-1 alpha: 10 [0.7-27] versus 3.3 [0.5-7.3] ng/ml; and mean Kd: 5.5 [5-7] versus 11 [4-16] pM). The antibodies did not cross-bind human recombinant IL-1 beta, IL-2, IL-6, or tumour necrosis factor alpha (TNF-alpha). It is concluded that native IL-1 alpha seems to trigger production of specific, high-avidity IgG antibodies in a relatively large number of normal individuals. These autoantibodies may regulate immunoinflammatory processes involving IL-1 alpha.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Svenson M,Bagge Hansen M,Bendtzen K

doi

10.1111/j.1365-3083.1990.tb03212.x

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

695-701

issue

6

eissn

0300-9475

issn

1365-3083

journal_volume

32

pub_type

杂志文章

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