DNA vaccine encoding ESAT-6 enhances the protective efficacy of BCG against Mycobacterium tuberculosis infection in mice.

abstract：:The addition of a small proportion (10%) of in vivo concanavalin-A (Con-A)-activated spleen cells to normal spleen cell cultures suppressed the primary immune response to sheep erythrocytes (SRBC) but had no effect on the thymus-independent primary immune response to 3,5-dinitro-4-hydroxy-phenacetyl-conjugated lipopol...

journal_title：Scandinavian journal of immunology

authors： Ekstedt RD,Waterfield JD,Nespoli L,Möller G

更新日期：1977-01-01 00:00:00

abstract：:Proteins immobilized on insoluble carriers or immunoadsorbents are now widely used in many areas of biological research. They are especially efficient in studies of complex protein mixtures because immunoadsorbents are very useful for isolation of individual components for further investigation. Antibodies immobilized...

journal_title：Scandinavian journal of immunology

authors： Nezlin R

更新日期：2005-07-01 00:00:00

abstract：:Human mast cell carboxypeptidase (hMC-CP) is a unique product of mast cells. Unlike tryptase and chymase, its potential function and expression in diseased conditions remain largely unknown. To develop an assay for hMC-CP, the recombinant fusion protein of hMC-CP and purified native skin hMC-CP was prepared, and two n...

journal_title：Scandinavian journal of immunology

authors： Zhou Y,Chen Z,He S

更新日期：2006-11-01 00:00:00

abstract：:In the absence of an affordable conjugate meningococcal vaccine, mass vaccination campaigns with polysaccharide vaccines are the means to control meningitis epidemics in sub-Saharan Africa. Facing global vaccine shortage, the use of reduced doses, which have been shown to be protective by serum bactericidal activity, ...

journal_title：Scandinavian journal of immunology

authors： Bårnes GK,Naess LM,Rosenqvist E,Guerin PJ,Caugant DA,Fractional Doses Vaccine Study Group.

更新日期：2011-07-01 00:00:00

abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

journal_title：Scandinavian journal of immunology

authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

更新日期：1998-10-01 00:00:00

abstract：:Behçet's disease (BD) is a heterogeneous multi-organ disorder in search of a unified pathophysiological theory and classification. The disease frequently has overlapping features resembling other disease clusters, such as vasculitides, spondyloarthritides and thrombophilias with similar genetic risk variants, namely H...

journal_title：Scandinavian journal of immunology

authors： Perazzio SF,Allenspach EJ,Eklund KK,Varjosalo M,Shinohara MM,Torgerson TR,Seppänen MRJ

更新日期：2020-11-01 00:00:00

abstract：:An immunization protocol that induces antibodies (Abs) directed to cryptic epitopes of a protein antigen (Ag) reduces the efficacy of vaccines that ideally should induce Abs against native epitopes. We have shown earlier that viral infections concomitant with immunization against a protein tend to shift the Ab specifi...

journal_title：Scandinavian journal of immunology

authors： Gómez KA,Longhi SA,Marino VJ,Mathieu PA,Loureiro ME,Coutelier JP,Roguin LP,Retegui LA

更新日期：2003-02-01 00:00:00

abstract：:The in vitro anti-trinitrophenyl (TNP) response induced by TNP-lipopolysaccharide (TNP-LPs) in mouse spleen cells was eliminated by passage through Sephadex G10 columns. Conditioned medium obtained from peritoneal macrophages restored the response, indicating the supportive role of such cells in the response. Converse...

journal_title：Scandinavian journal of immunology

authors： Martinez-Alonso C,Bernabe RR,Diaz-Espada F

更新日期：1980-01-01 00:00:00

abstract：:Conditions for the cloning of alloactivated human lymphocytes by limiting dilution in the presence of interleukin 2 (IL 2) and filler cells have been investigated. Cloning efficiencies were extremely high (at least 40%) when IL 2 derived from pooled peripheral blood mononuclear cells (PBM), stimulated with phytohaemag...

journal_title：Scandinavian journal of immunology

authors： Kahle P,Wernet P,Rehbein A,Kumbier I,Pawelec G

更新日期：1981-11-01 00:00:00

abstract：:Thymocytes that bind with high affinity to peptides displayed by MHC class II (pMHC-II) are deleted while low-affinity binders differentiate into naive CD4+ T cells. However, Foxp3+ regulatory T cells (Tregs) seem to defy this binary choice as their precursors require high-affinity interaction with pMHC-II for maturat...

journal_title：Scandinavian journal of immunology

authors： Usharauli D,Kamala T

更新日期：2021-01-01 00:00:00

abstract：:TNF-alpha production has a central role in the development and progression of Pseudomonas aeruginosa septic shock. We have previously shown that P. aeruginosa slime-glycolipoprotein (slime-GLP) is the most potent stimulant compared to P. aeruginosa lipopolysaccharide (LPS), for TNF-alpha production and NF-kB activatio...

journal_title：Scandinavian journal of immunology

authors： Lagoumintzis G,Xaplanteri P,Dimitracopoulos G,Paliogianni F

更新日期：2008-02-01 00:00:00

abstract：:Phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN) on the surface of endothelial cells is accompanied by adherence of the PMN to the endothelial surface and detachment of the endothelial cells from the culture monolayer. We studied the role of the leucocyte adherence-related glycoprotein...

journal_title：Scandinavian journal of immunology

authors： Vandenbroucke-Grauls CM,Thijssen HM,Tetteroo PA,Rozemuller E,Verhoef J

更新日期：1989-07-01 00:00:00

abstract：:An antiserum to unstimulated rat peritoneal macrophages was produced in rabbits. The antibodies were directed against an acidic protein with a molecular weight of 35,000 and with an isoelectric point at 4.6. The macrophage acidic protein (MAP) was purified by gel filtration of rat lung soluble proteins, followed by pr...

journal_title：Scandinavian journal of immunology

authors： Persson LI,Hansson E,Rönnbäck L

更新日期：1981-10-01 00:00:00

abstract：:The possible immunological relationship between the pattern of Th1/Th2 cytokine production and tuberculin reactivity was assessed in patients with active Mycobacterium tuberculosis infection. The production of the intracellular cytokines interferon (IFN)-gamma and interleukin-4 (IL-4) was measured in CD4(+) and CD8(+)...

journal_title：Scandinavian journal of immunology

authors： Boras Z,Juretić A,Gagro A,Pavelić Lj

更新日期：2007-03-01 00:00:00

abstract：:Osteoclasts are responsible for bone destruction in rheumatoid arthritis (RA), and adipose-derived mesenchymal stromal cells (ADSCs) can inhibit experimental collagen-induced arthritis model. This study aims to determine whether ADSCs also suppresses osteoclastogenesis and bone erosion in collagen-induced arthritis (C...

journal_title：Scandinavian journal of immunology

authors： Chang Q,Li C,Lu Y,Geng R,Wei JN,Hu JZ

更新日期：2020-08-01 00:00:00

abstract：:The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL-4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tum...

journal_title：Scandinavian journal of immunology

authors： Warren HS,Lafferty KJ

更新日期：1979-01-01 00:00:00

abstract：:Systemic lupus erythematosus is a systemic autoimmune disorder of unknown aetiology but is most likely caused by an interaction between several genetic factors and the environment. In a previously published genome scan we presented linkage to a marker on chromosome 4p13 in Icelandic families. Fine mapping of the regio...

journal_title：Scandinavian journal of immunology

authors： Johansson CM,Kristjánsdottir H,Gröndal G,Steinsson K,Alarcón-Riquelme ME

更新日期：2006-09-01 00:00:00

abstract：:There is strong evidence from animal models that placental and/or breast milk-mediated transfer of maternal allergen-specific IgG prevents allergic immune responses in the progeny. Both human and animal data also point to IgA as having an important regulatory role. In contrast, little is known about maternal transfer ...

journal_title：Scandinavian journal of immunology

authors： Macchiaverni P,Arslanian C,Frazão JB,Palmeira P,Russo M,Verhasselt V,Condino-Neto A

更新日期：2011-12-01 00:00:00

abstract：:This paper briefly reviews commonly used procedures for separation of mononuclear cells (MNC) and granulocytes from human blood with X-ray contrast media as gradient material, and also presents new and modified procedures for leucocyte preparation. Standard techniques for human blood do not always yield satisfactory r...

journal_title：Scandinavian journal of immunology

authors： Bøyum A,Løvhaug D,Tresland L,Nordlie EM

更新日期：1991-12-01 00:00:00

abstract：:Lewis rats develop arthritis after immunization with heterologous but not homologous rat type II collagen (CII). We have observed that if the rat CII is prepared by pepsin digestion without subsequent extensive purification, it is arthritogenic in Lewis rats. To address whether pepsin in the CII preparations contribut...

journal_title：Scandinavian journal of immunology

authors： Vingsbo C,Larsson P,Andersson M,Holmdahl R

更新日期：1993-03-01 00:00:00

abstract：:The major rheumatoid factor cross-reactive idiotype, which was defined by prototypic monoclonal IgM rheumatoid factors from Waldenstrom's macroglobulinaemia patient Wa, is present on 60% of all monoclonal IgM RF paraproteins. One-third of patients with juvenile rheumatoid arthritis (JRA), who are seronegative for clas...

journal_title：Scandinavian journal of immunology

authors： Ilowite NT,Wedgwood JF,Moore TL,Ramakrishnan T,Bonagura VR

更新日期：1991-10-01 00:00:00

abstract：:Spleen cells or thymocytes immune to one H-2 genotype are cytotoxic to allogeneic target cells of a third-party genotype, provided the target shares private specificities determined by either the H-2K or the H-2D locus of the H-2 complex with the H-2 genotype used for sensitization in vivo. The present results on elim...

journal_title：Scandinavian journal of immunology

authors： Jorgensen PN,Güttler F,Rubin B

更新日期：1975-01-01 00:00:00

abstract：:The c-Met oncoprotein is a cell-surface receptor for hepatocyte growth factor (HGF). Signals through HGF and c-Met have been appreciated for their crucial roles in the development of many cell types, including liver cells. The present study examined whether c-Met is expressed in the thymus and whether c-Met/HGF signal...

journal_title：Scandinavian journal of immunology

authors： Tamura S,Sugawara T,Tokoro Y,Taniguchi H,Fukao K,Nakauchi H,Takahama Y

更新日期：1998-04-01 00:00:00

abstract：:In murine schistosomiasis mansoni the worm egg-induced granulomatous inflammation is bi-phasic: an initial Th1 type is subsequently switched to a Th2 type response. Analysis of the cellular, molecular base of the Th1-associated response (5-6 weeks post infection) revealed mRNA messages for interleukin (IL)-12 p40, IL-...

journal_title：Scandinavian journal of immunology

authors： Todt JC,Whitfield JR,Ivard SR,Boros DL

更新日期：2000-10-01 00:00:00

abstract：:Spleens from newborn mice less than 6-7 days of age contain 'naturally occurring' suppressor cell populations that are able to inhibit nonspecifically immune responses of third-party adult spleen cells and alloreactivity in the newborn spleen per se. Isolation of the effectors of this suppressor activity reveals that ...

journal_title：Scandinavian journal of immunology

authors： Peeler K,Wigzell H,Peck AB

更新日期：1983-05-01 00:00:00

abstract：:Jacalin, a D-galactose-specific lectin from jackfruit, interacts with human IgA and one or two other serum proteins. Incubation of jacalin with fresh human serum was shown to result in activation of the complement system. Therefore the mechanism of complement activation by jacalin was studied. Jacalin was extracted fr...

journal_title：Scandinavian journal of immunology

authors： Hiemstra PS,Gorter A,Stuurman ME,Van Es LA,Daha MR

更新日期：1987-08-01 00:00:00

abstract：:IgG1 is cleaved in vitro by granulocyte elastase into Fc and Fab fragments. The elastase-specific Fc fragment has been previously detected in vivo. Biological activity of the fragments has been described in modulating neutrophil oxidative metabolism and enzyme release. To investigate further effects granulocyte chemot...

journal_title：Scandinavian journal of immunology

authors： Eckle I,Kolb G,Havemann K

更新日期：1991-09-01 00:00:00

abstract：:Human CD26 has dipeptidyl peptidase-4 (DPP IV) enzyme activity and binds to adenosine deaminase (ADA). CD26 is costimulatory for lymphocytes and has a circulating soluble form (sCD26). DPP IV enzyme inhibition is a new successful type 2 diabetes therapy. We examined whether the ADA binding and catalytic functions of s...

journal_title：Scandinavian journal of immunology

authors： Yu DM,Slaitini L,Gysbers V,Riekhoff AG,Kähne T,Knott HM,De Meester I,Abbott CA,McCaughan GW,Gorrell MD

更新日期：2011-02-01 00:00:00

abstract：:The production of type 1 (interferon or IFN-gamma) and type 2 (interleukin or IL-4 and IL-10) cytokines by mitogen-stimulated peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic human immunodeficiency virus-seropositive (HIV+) patients untreated with any antiviral, antibacterial or antimycotic drugs,...

journal_title：Scandinavian journal of immunology

authors： Canaris AD,Caruso A,Licenziati S,Cantalamessa A,De Francesco MA,Fallacara F,Fiorentini S,Dima F,Martinelli F,Manca N,Balsari A,Turano A

更新日期：1998-02-01 00:00:00

abstract：:Human peripheral lymphocytes were cultivated in soft agar or agarose, containing 3H-thymidine or bromodeoxyuridine (BrdU), which is an analogue of thymidine readily incorporated into deoxyribonucleic acid by lymphocytes. Colonies were isolated and analysed by autoradiography or stained with the fluorescence-plus-Giems...

journal_title：Scandinavian journal of immunology

authors： Lindahl-Kiessling K,Karlberg I

更新日期：1981-05-01 00:00:00