Coexistence of protein AA and immunoglobulin light-chain fragments in amyloid fibrils.

abstract：:Peripheral blood mononuclear leucocytes (PBLs) stimulated in vitro by heat-killed formaldehyde-fixed Staphylococcus aureus Cowan I (SACoI) produced acid-labile alpha interferon (IFN-alpha) and, to various extents, also IFN-gamma. The IFN producers resided in nylon wool-nonadherent cells, and monocytes suppressed SACoI...

journal_title：Scandinavian journal of immunology

authors： Funa K,Ramstedt U,Rönnblom L,Alm GV

更新日期：1985-01-01 00:00:00

abstract：:A solid-phase radioimmunoassay for detection of circulating C1q-binding immune complexes (IC) or heat-aggregated IgG (delta IgG) is described. Purified human C1q protein was adsorbed to a fixed area of polystyrene tube surface for 1 hr at 22 degrees C, pH 7.3, mu 0.15. Binding of delta IgG or IC to solid-phase C1q at ...

journal_title：Scandinavian journal of immunology

authors： Svehag SE

更新日期：1975-01-01 00:00:00

abstract：:Two cytokines, interferon (IFN) and interleukin 2 (IL-2), activate murine natural killer (NK) cells in vitro. Together both factors synergize considerably. Antibody against IFN eliminates the response of NK cells to IFN as well as to IL-2, whereas antibody against IL-2 blocks the effect of IL-2 but not of IFN. These f...

journal_title：Scandinavian journal of immunology

authors： Chun M,Krim M,Granelli-Piperno A,Hirst JA,Hoffmann MK

更新日期：1985-10-01 00:00:00

abstract：:The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primar...

journal_title：Scandinavian journal of immunology

authors： Carvalho LJ,Oliveira SG,Theisen M,Alves FA,Andrade MC,Zanini GM,Brígido MC,Oeuvray C,Póvoa MM,Muniz JA,Druilhe P,Daniel-Ribeiro CT

更新日期：2004-04-01 00:00:00

abstract：:The T-cell regulatory function has been evaluated in lines of mice genetically selected according to the High (H) and Low (L) antibody responsiveness to heterologous erythrocytes. The inhibition of antibody production following CD4+ subset depletion was stronger in L than in H mice. The dose of CD4-specific monoclonal...

journal_title：Scandinavian journal of immunology

authors： Cabrera WH,Siqueira M,Takahashi NS,Ribeiro OG,Araujo LM,Mouton D,Ibanez OM

更新日期：1995-03-01 00:00:00

abstract：:Ebola viruses (EBOVs) have been identified as an emerging threat in recent year as it causes severe haemorrhagic fever in human. Epitope-based vaccine design for EBOVs remains a top priority because a mere progress has been made in this regard. Another reason is the lack of antiviral drug and licensed vaccine although...

journal_title：Scandinavian journal of immunology

authors： Khan MA,Hossain MU,Rakib-Uz-Zaman SM,Morshed MN

更新日期：2015-07-01 00:00:00

abstract：:Based on CD14 and CD16 expression, human peripheral blood monocytes (MO) can be divided into a major CD14(high) CD16(-) population and two minor CD14(high) CD16(+) and CD14(dim) CD16(+) subpopulations. CD14(dim) CD16(+) MO are well characterized and regarded as pro-inflammatory because upon stimulation produce TNF-alp...

journal_title：Scandinavian journal of immunology

authors： Skrzeczyńska-Moncznik J,Bzowska M,Loseke S,Grage-Griebenow E,Zembala M,Pryjma J

更新日期：2008-02-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) possesses an antimicrobial effect in several animal models of infection. To evaluate a possible effect of G-CSF on the course of pneumococcal meningitis, rabbits infected intracisternally (i.c.) with Streptococcus pneumoniae type 3 (n = 7) received 50 microgram/kg of rhG-C...

journal_title：Scandinavian journal of immunology

authors： Schmidt H,Stuertz K,Brück W,Chen V,Stringaris AK,Fischer FR,Nau R

更新日期：1999-05-01 00:00:00

abstract：:Inflammatory cytokines appear to be involved in damage to Schwann cells, myelin and axons, although the exact role of the different cytokines is uncertain. The direct injection model offers a new and simplified way of examining the mechanisms of early inflammation in the peripheral nervous system. The present study wa...

journal_title：Scandinavian journal of immunology

authors： Pelidou SH,Deretzi G,Zou LP,Quiding C,Zhu J

更新日期：1999-07-01 00:00:00

abstract：:The immune system of a healthy individual responds vigorously to foreign microbial antigens. However, all potentially immunogenic regions (determinants) within an antigen are not functionally of equal relevance in mediating host immunity against the pathogen. Moreover, some of these antigenic determinants are well pro...

journal_title：Scandinavian journal of immunology

authors： Sinha P,Snyder JA,Kim EY,Moudgil KD

更新日期：2007-02-01 00:00:00

abstract：:Human endothelial cells (EC), cultured serum-free, synthesize de novo protein which increasingly bind to agarose beads (an alternative pathway activator), until a plateau phase is reached after 24-48 h. EC synthesize functional C3, C5, C6, C8 and C9, which were detected on co-cultured agarose beads, using relevant pol...

journal_title：Scandinavian journal of immunology

authors： Johnson E,Hetland G

更新日期：1991-06-01 00:00:00

abstract：:In order to understand why most strains of Biozzi mice are unexpectedly either arthritis-resistant, or susceptible, we investigate the autoantibody reactivity against matrix-embedded collagen molecules. We show a close correlation between these tissular and the free collagen antibodies, irrespective of arthritis susce...

journal_title：Scandinavian journal of immunology

authors： Bouvet JP,Franc B,Zyad A,Couderc J

更新日期：1992-06-01 00:00:00

abstract：:Human natural killer (NK) cells are able to adhere to xenogeneic porcine endothelial cells (EC) and evidence from in vitro studies as well as animal models suggests a potential role for NK cells in the cellular recognition and damage of porcine xenogeneic tissues. One possible explanation for the observed NK cell-medi...

journal_title：Scandinavian journal of immunology

authors： Schneider MK,Forte P,Seebach JD

更新日期：2001-07-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4) participates in innate immunity by detecting lipopolysaccharides (LPS) of Gram-negative bacterial cell walls. TLR4 macrophage expression in mice is modulated by LPS. This fact constitutes, at least partially, the molecular basis for LPS tolerance. Very recently, the effect of interferon-gam...

journal_title：Scandinavian journal of immunology

authors： Moreno C,Merino J,Vázquez B,Ramírez N,Echeverría A,Pastor F,Sánchez-Ibarrola A

更新日期：2004-06-01 00:00:00

abstract：:The in vitro immune response of lymphocytes from uraemic patients was studied by comparing the in vitro kinetics of interleukin 2 (IL-2) production, the mitogen-induced proliferative response, and the expression of IL-2 receptors by T lymphocytes. The IL-2 production in 26 uraemic cell cultures decreased significantly...

journal_title：Scandinavian journal of immunology

authors： Langhoff E,Hofmann B,Odum N,Ladefoged J,Platz P,Ryder LP,Svejgaard A

更新日期：1987-01-01 00:00:00

abstract：:Chronic inflammatory diseases are now treated with a range of different biopharmaceuticals, often requiring lifelong parenteral administrations. This exposure to drugs is unnatural and can trigger the immune system and result in the formation of antidrug antibodies. Drug-specific antibodies will, if of sufficiently hi...

journal_title：Scandinavian journal of immunology

authors： Fogdell-Hahn A

更新日期：2015-09-01 00:00:00

abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

journal_title：Scandinavian journal of immunology

authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

更新日期：1998-10-01 00:00:00

abstract：:The humoral response against the bacterial polysaccharide antigen alpha(1-->3) dextran (Dex) is controlled by J558 idiotype-(Id) specific T cells. These T cells of which the cell clone 178-4 Ts is a representative by all relevant criteria, recognize J558 Id-bearing B cells in an I-Ed-restricted manner. Costimulation v...

journal_title：Scandinavian journal of immunology

authors： Rademaekers A,Specht C,Kölsch E

更新日期：2001-03-01 00:00:00

abstract：:Experimental amyloidosis was induced in mice by intraperitoneal injections of endotoxin (lipopolysaccharide (LPS)). In addition to LPS, a group of mice received high-density lipoprotein (HDL)-SAA complexes isolated from human acute-phase serum, whereas a group of control mice received saline in addition to LPS. Isolat...

journal_title：Scandinavian journal of immunology

authors： Husebekk A,Skogen B,Husby G,Marhaug G

更新日期：1985-03-01 00:00:00

abstract：:Glomerular complement receptors (GCR) were demonstrated by the adsorption of C3 coated sheep erythrocytes to cryostat sections of human kidneys. An epithelial localization of the GCR is implied by the binding pattern of the indicator cells. The GCR activity was reduced in all glomeruli where in vivo deposition of immu...

journal_title：Scandinavian journal of immunology

authors： Matre R,Iversen BM,Thunold S,Tønder O

更新日期：1978-01-01 00:00:00

abstract：:Antibodies to crude leukocyte interferon (CIF) were bound to Sepharose 4B, and CIF was chromatographed. A relationship between recovered interferon and percentage binding of the antibodies to Sepharose 4B was observed. Highest recovery was obtained when only 50%-85% of th- antibodies were bound. When CIF was subjected...

journal_title：Scandinavian journal of immunology

authors： Berg K

更新日期：1977-01-01 00:00:00

abstract：:Human T lymphocytes, upon phytohaemagglutinin stimulation, are able to form colonies in semisolid media. Peripheral T cell bearing Fc receptors (TG) were studied for their possible regulatory activity on lymphoid colony development. Although no substantial differences were observed between the cloning efficiency of un...

journal_title：Scandinavian journal of immunology

authors： Canonica GW,Pistoia V,Ghio R,Mingari MC,Moretta L

更新日期：1980-01-01 00:00:00

abstract：:The purpose of this study was to investigate interleukin 2 (IL-2) and gamma interferon (IFN-gamma) production by purified CD4+ and CD8+ cells isolated from peripheral blood (PB) and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and other inflammatory arthritides (non-RA). CD4+ and CD8+ cells were sele...

journal_title：Scandinavian journal of immunology

authors： Hovdenes J,Gaudernack G,Kvien TK,Hovdenes AB,Egeland T

更新日期：1989-11-01 00:00:00

abstract：:Increased serum immunoglobulin A (IgA) level is a common finding in primary Sjögren's syndrome (pSS). IgA might not be properly eliminated because of an abnormal glycosylation. We reported previously that IgA1 from patients with pSS was oversialylated. We extend this finding by showing that monomeric IgA1 contains mor...

journal_title：Scandinavian journal of immunology

authors： Basset C,Durand V,Jamin C,Clément J,Pennec Y,Youinou P,Dueymes M,Roitt IM

更新日期：2000-03-01 00:00:00

abstract：:To investigate autologous antigen recognition, we developed two autoreactive CD4+ T-cell clones, A2 and A10, maintained with non-T cells and IL-2. Autologous non-T-cell stimulation of the T-cell clones resulted in a decrease in cell surface expression of CD4, whereas the expression of CD2, CD3, and WT31 was unchanged....

journal_title：Scandinavian journal of immunology

authors： Hara M,Kitani A,Harigai M,Suzuki K,Hirose T,Kawakami M,Kawagae M,Nakamura H

更新日期：1991-02-01 00:00:00

abstract：:A method of isolation has been developed to purify mast cells from human lung tissue. The purification steps are: (1) dispersion of human lung tissue in single-cell suspensions by enzymatic digestion, (2) partial purification by counterflow centrifugal elutriation, (3) Percoll gradient centrifugation, and (4) enrichme...

journal_title：Scandinavian journal of immunology

authors： van Overveld FJ,Terpstra GK,Bruijnzeel PL,Raaijmakers JA,Kreukniet J

更新日期：1988-01-01 00:00:00

abstract：:Previous work from our laboratory demonstrated that a synthetic heptapeptide (Ch7: RGSDIAG), corresponding to a conserved sequence of human immunodeficiency virus (HIV) core protein p24 (amino acids 232- 238), was able to specifically abrogate antigen-induced responses in cultures of normal human peripheral blood mono...

journal_title：Scandinavian journal of immunology

authors： Giacomini E,Chersi A,Giordani L,Luzzati AL

更新日期：2000-02-01 00:00:00

abstract：:Flow cytometric analysis of splenocytes from mice infected with lymphocytic choriomeningitis virus revealed marked and long-standing up-regulation of LFA-1 expression on CD8+, but not on CD4+ T cells. Appearance of CD8+ T cells with a changed expression of adhesion molecules reflected polyclonal activation and expansi...

journal_title：Scandinavian journal of immunology

authors： Andersson EC,Christensen JP,Scheynius A,Marker O,Thomsen AR

更新日期：1995-07-01 00:00:00

abstract：:Allogeneic chimaeras that utilize C.B-17 SCID mice (H-2d) as recipients of MHC mismatched bone marrow from C57B1/6 (H-2b) or SJL/J (H-2s) mice have been used to provide experimental evidence demonstrating the necessity for a direct interaction between an effector T helper and the cytotoxic T-cell precursor in order to...

journal_title：Scandinavian journal of immunology

authors： Lin Y,Langman R,Cohn M

更新日期：1992-05-01 00:00:00

abstract：:The human serum amyloid A (SAA) gene family consists of two acute phase genes, SAA1 and SAA2; a pseudogene, SAA3 and a fourth gene, SAA4. The existence of SAA4 was first described in this laboratory. Subsequently, Sack & Talbot isolated a clone, designated GSAA4, which had homology to SAA3. The clone was described as ...

journal_title：Scandinavian journal of immunology

authors： Watson G,Faulkes DJ,Woo P

更新日期：1994-08-01 00:00:00