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Complement receptors in pathological human renal glomeruli.

Abstract：

:Glomerular complement receptors (GCR) were demonstrated by the adsorption of C3 coated sheep erythrocytes to cryostat sections of human kidneys. An epithelial localization of the GCR is implied by the binding pattern of the indicator cells. The GCR activity was reduced in all glomeruli where in vivo deposition of immunoglobulin and C3 along the capillary wall was observed. In fourteen out of nineteen biopsies where deposits in the mesangium were seen, reduced GCR activity was also observed, whereas GCR activity was normal in the other five. Immunofluorescence and haemadsorption tests performed on the same section showed that C3 deposits corresponded to areas showing reduced complement receptor activity. Areas outside the C3 deposits adsorbed indicator cells coated with various amounts of C3 similarly to the adsorption to glomeruli seen in normal adult and fetal kidneys. Sclerotic glomeruli showed no GCR activity. The results indicate that the complement receptors play a role for the binding of complement-containing complexes in glomeruli.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Matre R,Iversen BM,Thunold S,Tønder O

doi

10.1111/j.1365-3083.1978.tb00470.x

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

399-404

issue

5

eissn

0300-9475

issn

1365-3083

journal_volume

7

pub_type

杂志文章

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