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Cellular interactions between synovial T-cell clones from a patient with rheumatoid arthritis.

Abstract：

:The aim of this study was to investigate T-T cell interactions that may be involved in the pathogenesis of chronic synovitis. Two CD4+ T-cell clones, termed N16 and N18, sharing similar cytokine profiles were isolated from the synovial tissue of a patient with rheumatoid arthritis. Activated N16 cells induced proliferation of N18 cells in the absence of accessory cells, while the proliferative response of N18 cells to activated N18 cells depended on the presence of accessory cells. Whereas the response of N18 to activated N18 cells could be blocked by MoAbs against HLA class I and LFA-1 molecules, the response of N18 to activated N16 cells was only weakly affected, suggesting that the surface molecules involved in this interaction differed. Indeed, using MoAbs against CD3, CD4 and to a lesser extent CD2, proliferation of N18 to activated N16 cells was abrogated. These data provide a model for T-T cell interactions involved in the development of chronic synovitis.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Van Laar JM,Miltenburg AM,De Kuiper P,Daha MR,De Vries RR,Breedveld FC

doi

10.1111/j.1365-3083.1993.tb01678.x

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

651-5

issue

6

eissn

0300-9475

issn

1365-3083

journal_volume

37

pub_type

杂志文章

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