Abstract：
:To evaluate the level of lymphocyte activation in reactive and rheumatoid arthritis, density gradient-isolated, synovial fluid mononuclear cells were stained with a panel of antisera directed at lymphocyte activation markers using an avidin-biotin-peroxidase complex (ABC) method. More specifically, we studied the expression of immune response-associated class II HLA antigen (Ia), of receptors for interleukin 2 (Tac) and transferrin (T9), as well as of gp 40/80 glycoprotein (4F2). Although Ia+ cells formed about 60% of all the synovial fluid mononuclear cells in both disease conditions, the proportion of Tac+ (33 +/- 4% vs 3 +/- 1%, P less than 0.001), T9+ (34 +/- 4% vs 5 +/- 2%, P less than 0.001), and 4F2+ (48 +/- 6% vs 3 +/- 2%, P less than 0.001) cells was high only in reactive arthritis. All the patients who had reactive arthritis followed a favourable clinical course during the 4-month-long prospective follow-up, whereas disease activity was stable in patients with rheumatoid arthritis. These findings suggest that the diseased joints in reactive arthritis are a site for an active, but normally down-regulated, cell-mediated immune response.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Konttinen YT,Nordström D,Bergroth V,Leirisalo-Repo M,Skrifvars Bdoi
10.1111/j.1365-3083.1986.tb02005.xsubject
Has Abstractpub_date
1986-06-01 00:00:00pages
685-91issue
6eissn
0300-9475issn
1365-3083journal_volume
23pub_type
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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更新日期：1999-01-01 00:00:00
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1978.tb00529.x
更新日期：1978-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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doi：10.1111/j.1365-3083.1995.tb03709.x
更新日期：1995-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1993.tb01678.x
更新日期：1993-06-01 00:00:00
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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更新日期：2015-11-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1984.tb00911.x
更新日期：1984-02-01 00:00:00
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更新日期：2003-11-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章,评审
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更新日期：2010-03-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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更新日期：1994-07-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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更新日期：1984-03-01 00:00:00
