当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjögren's syndrome.

Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjögren's syndrome.

Abstract：

:CD27 has been found to be expressed on somatically mutated B cells and is thus a positive marker for memory B cells in peripheral blood (PB). Since abnormal immunogloblin (Ig) production is characteristic of the autoimmune diseases primary Sjögren's syndrome (pSS) and rheumatoid arthritis (RA), we have analyzed in detail the CD27 expression on PB B cell from these patient groups. Staining of PB B cells with monoclonal antibodies (MoAb) specific for CD19 and CD27 revealed a significantly depressed percentage of CD27+ PB B cells in patients with pSS (14.8 +/- 1.6%) compared to both healthy donors (31.3 +/- 4.7%, P = 0.005) and patients with RA (40.8 +/- 4.1%, P = 0.0001). In addition, the percentages of both the IgD+CD27+ and the IgD-CD27+ B-cell subpopulations were significantly lower in pSS patients compared to RA patients and healthy donors. However, the relative proportion of IgD- and IgD+ cells among the CD27+B cells were almost the same for the three groups. Our data suggest a disturbance in the differentiation of peripheral B cells and possibly a bias towards plasma cell differentiation, resulting in a depressed percentage of CD27+ memory PB B cells in pSS. These results are potentially of pathological significance and of diagnostic value.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Bohnhorst JO,Thoen JE,Natvig JB,Thompson KM

doi

10.1046/j.1365-3083.2001.00989.x

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

421-7

issue

4

eissn

0300-9475

issn

1365-3083

pii

sji989

journal_volume

54

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • Flow cytometric analysis of lymphocyte subsets in the bronchoalveolar lavage fluid and peripheral blood of healthy volunteers.

    abstract：:The lymphocyte subsets in the bronchoalveolar lavage fluid (BALF) and the peripheral blood of 25 healthy volunteers were examined by analysis with a fluorescence-activated cell sorter. Comparison of the lymphocyte subsets in the BALF with those of the peripheral blood revealed much higher values for the ratios of each...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02171.x

    authors： Yamada M,Tamura N,Shirai T,Kira S

    更新日期：1986-11-01 00:00:00

  • Peripheral circulating activated b-cell populations are associated with nephritis and disease activity in patients with systemic lupus erythematosus.

    abstract：:B-cell-dependent autoantibody production is a hallmark of systemic lupus erythematosus (SLE) which requires costimulatory molecules. The aim of the study was to analyse the expression of costimulatory molecules on B cells in patients with SLE. Twenty-six patients with SLE (four male, 22 female, mean age 46 +/- 15 year...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2007.02008.x

    authors： Dolff S,Wilde B,Patschan S,Dürig J,Specker C,Philipp T,Kribben A,Witzke O

    更新日期：2007-11-01 00:00:00

  • The role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages.

    abstract：:The in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of Listeria monocytogenes EGD (listeria) by peritoneal macrophages (PM) was investigated. Generation of superoxide anion by PM stimulated with phorbol myristate acetate (PMA) was significantly increased by intraperitoneal injection of...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02131.x

    authors： Hashimoto S,Nomoto K,Yokokura T

    更新日期：1986-10-01 00:00:00

  • Hypothesis for the control of clotting factor VIII inhibitory antibodies by decreasing potency of helper T-cell-recognized epitopes in factor VIII.

    abstract：:The study of the immunobiology of FVIII inhibitors may lead to new therapies for this potentially severe complication of haemophilia A and to new principles for the use of therapeutic proteins. In order to characterize the idiotype-anti-idiotype networks regulating FVIII inhibitors, we developed rabbit anti-idiotypic ...

    journal_title：Scandinavian journal of immunology

    pub_type： 社论,评审

    doi：10.1111/j.1365-3083.1992.tb03125.x

    authors： Tiarks C,Humphreys RE,Anderson J,Mole J,Pechet L

    更新日期：1992-11-01 00:00:00

  • Multiple ICAM-1 (CD54) epitopes are involved in homotypic B-cell adhesion.

    abstract：:Two monoclonal antibodies (MoAbs), F10.2 and F10.3, were selected for their ability to interfere in homotypic adhesion of human B cells. Precipitation studies and binding to intercellular adhesion molecule 1 (ICAM-1, CD54) cDNA transfected COS cells revealed that both MoAbs are directed against ICAM-1. The binding of ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1992.tb03250.x

    authors： Bloemen P,Moldenhauer G,van Dijk M,Schuurman HJ,Bloem AC

    更新日期：1992-05-01 00:00:00

  • The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus.

    abstract：:B-Lymphocyte-activating factor (BAFF/BLyS) is a survival factor for B cells, belonging to the tumor necrosis ligand super family. Serum BAFF levels have been found to be elevated in patients with systemic lupus erythematosus (SLE). Neutralization of BAFF activity was suggested as an additional therapeutic approach in ...

    journal_title：Scandinavian journal of immunology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-3083.2006.01737.x

    authors： Toubi E,Kessel A,Rosner I,Rozenbaum M,Paran D,Shoenfeld Y

    更新日期：2006-04-01 00:00:00

  • The fifth serum amyloid A-related gene sequence, GSAA4, is SAA3.

    abstract：:The human serum amyloid A (SAA) gene family consists of two acute phase genes, SAA1 and SAA2; a pseudogene, SAA3 and a fourth gene, SAA4. The existence of SAA4 was first described in this laboratory. Subsequently, Sack & Talbot isolated a clone, designated GSAA4, which had homology to SAA3. The clone was described as ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1994.tb03460.x

    authors： Watson G,Faulkes DJ,Woo P

    更新日期：1994-08-01 00:00:00

  • T-cell effector function and unresponsiveness in the murine lymphocytic choriomeningitis virus infection. I. On the mechanism of a selective suppression of the virus-specific delayed-type hypersensitivity response.

    abstract：:When the virus dose is increased from 10(2) (low dose) to 10(4) LD50 (high dose) a fatal lymphocytic choriomeningitis virus (LCMV) infection is changed into a subclinical one, and a selective virus-specific delayed-type hypersensitivity (DTH) unresponsiveness is induced, while the cytotoxic T-cell response remains ess...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02078.x

    authors： Marker O,Thomsen AR

    更新日期：1986-08-01 00:00:00

  • The effects of topical treatment with steroids or dithranol on epidermal T lymphocytes and dendritic cells in psoriasis.

    abstract：:We describe the effects of treatment with topical steroids or dithranol on T and dendritic cells in the skin of patients with chronic plaque psoriasis. Resolution of lesions by both types of topical treatments was accompanied by a marked decrease in epidermal T cells. In steroid treated lesions there was also a reduct...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1985.tb01905.x

    authors： Baker BS,Swain AF,Griffiths CE,Leonard JN,Fry L,Valdimarsson H

    更新日期：1985-11-01 00:00:00

  • A routine source of human peritoneal macrophages.

    abstract：:The routine availability of nucleated human cells for experimental use in limited in the absence of venipuncture. In this paper we have demonstrated that macrophages may be harvested routinely from the waste dialysis bags of patients undergoing continuous ambulatory peritoneal dialysis. These cells were identified as ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1984.tb00896.x

    authors： Maddox Y,Foegh M,Zeligs B,Zmudka M,Bellanti J,Ramwell P

    更新日期：1984-01-01 00:00:00

  • NK1.1 cells downregulate murine endotoxin-induced uveitis following intraocular administration of interleukin-12.

    abstract：:To evaluate the role of IFN-gamma (interferon gamma) in IL-12- (interleukin-12)-induced inhibition of the inflammatory response in the eye during endotoxin-induced uveitis (EIU). C57BL/6 wild type mice and IFN-gamma-deficient (GKO) mice were injected with 250 microg of Salmonella typhymurium endotoxin as a model for E...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2007.01988.x

    authors： Figueiredo F,Commodaro AG,de Camargo MM,Rizzo LV,Belfort R Jr

    更新日期：2007-08-01 00:00:00

  • Serum vitamin D levels and VDR polymorphisms (BsmI and FokI) in patients and their household contacts susceptible to tuberculosis.

    abstract：:Vitamin D, an immunomodulator of macrophage function, can activate human antimycobacterial activity. Vitamin D deficiency (VDD) is associated with an impaired mycobacterial immunity and susceptibility to tuberculosis. It has been found that vitamin D and its receptor may be essential for immune function. In this study...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12127

    authors： Joshi L,Ponnana M,Penmetsa SR,Nallari P,Valluri V,Gaddam S

    更新日期：2014-02-01 00:00:00

  • Hypoxia induces production of citrullinated proteins in human fibroblast-like synoviocytes through regulating HIF1α.

    abstract：:Hypoxia is a prominent microenvironment feature in a range of disorders including cancer, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel disease (IBD), infection and obesity. Hypoxia promotes biological functions of fibroblast-like synoviocytes via regulating hypoxia-inducible factor 1α (HIF1α). Dysreg...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12654

    authors： Yu R,Li C,Sun L,Jian L,Ma Z,Zhao J,Liu X

    更新日期：2018-04-01 00:00:00

  • Comparison between the specificity of primary and secondary killer cells against alloantigens and hapten-modified syngeneic lymphoid cells.

    abstract：:Cytotoxic responses of lymphoid cells from different mouse strains against syngeneic cells modified with the haptens fluorescein isothiocyanate and trinitrophenyl were investigated. Mic of the H-2k strain demonstrated strong primary in vitro hapten-specific cytotoxicity reactions, which were H-2 restricted and involve...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1981.tb00119.x

    authors： Möller E,Ramos T

    更新日期：1981-01-01 00:00:00

  • Effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat thymocytes.

    abstract：:The short-term incubation of rat thymocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a significant increase in sialyltransferase (S-T) activity and a decrease in terminal deoxyribonucleotidyl transferase (TdT) activity. The ratio of peanut agglutinin (PNA)-positive cells and of TdT-positive cells in...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01148.x

    authors： Sasaki R,Takaku F,Miura Y

    更新日期：1989-04-01 00:00:00

  • Evidence of aberration of T-cell subsets in aged individuals.

    abstract：:In the present study, T-cell subsets from aged individuals were examined by using anti-BAT (brain-associated thymocyte antigen) serum. Anti-BAT serum was raised against the human fetal brain at 28 weeks of gestation. After absorption wit AB erythrocytes, B-cell lines, and leukaemic cells, anti-BAT serum was T cell-spe...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1981.tb00121.x

    authors： Abe T,Morimoto C,Toguchi T,Kiyotaki M,Homma M

    更新日期：1981-01-01 00:00:00

  • Down-regulation of L-selectin surface expression by various leukocyte isolation procedures.

    abstract：:L-selectin, a cell surface glycoprotein expressed on lymphocytes, granulocytes, and monocytes, has been implicated in lymphocyte homing and extravasation of phagocytic leukocytes into areas of inflammation. Considerable differences of L-selectin expression among various individuals has been reported, with clinical cor...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：

    authors： Stibenz D,Bührer C

    更新日期：1994-01-01 00:00:00

  • Measurement of IgE on rat mast cells: relation to serum IgE and allergen-induced histamine release.

    abstract：:IgE antibodies against trinitrophenylated ovalbumin (TNP-OVA) were raised in Brown Norway rats by a highly reproducible immunization procedure. With these rats, the kinetics of the IgE response was studied, both for free circulating and cell-bound IgE. Cell-bound IgE was dissociated from peritoneal cell suspensions at...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1983.tb00760.x

    authors： van Toorenenbergen AW,van Swieten P,Aalberse RC

    更新日期：1983-01-01 00:00:00

  • Mechanisms whereby lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes.

    abstract：:During immunological rejection of the transplanted heart, cytotoxic T lymphocytes (CTL) infiltrate the myocardium and by damaging the myocytes contribute to loss of function. To address one important aspect of heart transplant rejection, we investigated in guinea pig ventricular myocytes how CTL-derived lytic granules...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1993.tb01664.x

    authors： Binah O,Kline R,Berke G,Hoffman B

    更新日期：1993-01-01 00:00:00

  • Isolation and characterization of sea star factor.

    abstract：:Sea star factor (SSF) harvested from the echinoderm Asterias forbesi celomocytes is a potent inhibitor of the primary immune response to T-dependent antigens and also suppresses concanavalin-A-induced mitogenesis. We have isolated and purified a basic protein from this source which has a molecular weight of approximat...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1976.tb03037.x

    authors： Prendergast RA,Liu SH

    更新日期：1976-01-01 00:00:00

  • Langerhans cells and T cells sense cell dysplasia in oral leukoplakias and oral squamous cell carcinomas--evidence for immunosurveillance.

    abstract：:Leukoplakias (LPLs) are lesions in the oral mucosa that may develop into oral squamous cell carcinoma (OSCC). The objective of this study was to assess presence and distribution of dendritic Langerhans cells (LCs) and T cells in patients with LPLs with or without cell dysplasia and in oral squamous cell carcinoma (OSC...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2012.02701.x

    authors： Öhman J,Magnusson B,Telemo E,Jontell M,Hasséus B

    更新日期：2012-07-01 00:00:00

  • Peripheral immune response in pulmonary tuberculosis.

    abstract：:Cellular immune response and delayed-type hypersensitivity reactions are considered to play a major role in the immunopathogenesis of pulmonary tuberculosis (PTB). But the exact mechanism is still to be clarified. Th1 cells are mainly involved in cellular immune responses in PTB and provide a normal healing process wi...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2009.02294.x

    authors： Aktas E,Ciftci F,Bilgic S,Sezer O,Bozkanat E,Deniz O,Citici U,Deniz G

    更新日期：2009-09-01 00:00:00

  • Bromelain treatment leads to maturation of monocyte-derived dendritic cells but cannot replace PGE2 in a cocktail of IL-1β, IL-6, TNF-α and PGE2.

    abstract：:Immunotherapy using dendritic cells (DC) has shown promising results. However, the use of an appropriate DC population is critical for the outcome of this treatment, and the search for an optimal DC subset is still ongoing. The DC used in immunotherapy today are usually matured with a cytokine cocktail consisting of T...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2011.02562.x

    authors： Karlsen M,Hovden AO,Vogelsang P,Tysnes BB,Appel S

    更新日期：2011-08-01 00:00:00

  • Galectin-3 is associated with severe heart failure and death: A hospital-based study in Chinese patients.

    abstract：:Heart failure (HF) is a serious disease syndrome characterized by elevated pro-inflammatory cytokines and inflammatory mediators presume to have significant contribution on disease progression. Galectins are carbohydrate-binding proteins responsible of various physiological functions. Role of galectins in heart failur...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12826

    authors： Wang N,Dang M,Zhang W,Lei Y,Liu Z

    更新日期：2020-05-01 00:00:00

  • Infliximab inhibits activation and effector functions of peripheral blood T cells in vitro from patients with clinically active ulcerative colitis.

    abstract：:Many patients with inflammatory bowel disease (IBD) are undergoing therapy with infliximab, an antibody specific for TNF. However, the exact mechanisms of action of infliximab are not completely understood. The aim of this study was to determine the in vitro effects of infliximab on blood T cells derived from anti-TNF...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12081

    authors： Dahlén R,Strid H,Lundgren A,Isaksson S,Raghavan S,Magnusson MK,Simrén M,Sjövall H,Öhman L

    更新日期：2013-09-01 00:00:00

  • Enhancement of cytotoxic activity of natural killer cells by interleukin 2, and antagonism between interleukin 2 and adenosine cyclic monophosphate.

    abstract：:Two cytokines, interferon (IFN) and interleukin 2 (IL-2), activate murine natural killer (NK) cells in vitro. Together both factors synergize considerably. Antibody against IFN eliminates the response of NK cells to IFN as well as to IL-2, whereas antibody against IL-2 blocks the effect of IL-2 but not of IFN. These f...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1985.tb01895.x

    authors： Chun M,Krim M,Granelli-Piperno A,Hirst JA,Hoffmann MK

    更新日期：1985-10-01 00:00:00

  • Activation of human neutrophils induced by immune complexes prepared with cationic and anionic fractions of normal IgG antibodies.

    abstract：:The authors have recently shown that the ability of immune complexes (IC) to trigger Fc gamma R-dependent cell responses can be dramatically enhanced when the isoelectric point (pI) of normal IgG antibodies is increased from 5.8-8.5 to 8.5-9.8 by treatment with 1-ethyl-3-2(3-dimethylaminopropyl) carbodiimide HCl and e...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1996.d01-40.x

    authors： Trevani AS,Andonegui G,Kempfer C,Malchiodi E,Geffner JR

    更新日期：1996-03-01 00:00:00

  • Kinetics of cytokine release and expression of lymphocyte cell-surface activation markers after in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae.

    abstract：:The aim of this study was to describe the kinetics of the cytokine release and the expression of activation markers on lymphocytes after stimulation of peripheral blood mononuclear cells (PBMC) with whole killed Streptococcus pneumoniae. The cytokine release and the expression of CD25 and HLA-DR on T cells, and CD69 o...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1999.00470.x

    authors： Arvå E,Andersson B

    更新日期：1999-03-01 00:00:00

  • Difference in the effect of immobilized ligands on the Fc and C3 receptors of mouse peritoneal macrophages in vitro.

    abstract：:The function of the Fc and C3 receptors on the free surface of normal and endotoxin activated mouse peritoneal macrophages seeded on glass bound antibody--antigen (AbAg) complexes or complement was examined. We found that the glass bound AbAg complexes interfered with attachment and internalization of particles recogn...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1978.tb00422.x

    authors： Kaplan G,Eskeland T,Seljelid R

    更新日期：1978-01-01 00:00:00

  • Alpha 1-microglobulin is mitogenic for guinea pig lymphocytes.

    abstract：:Guinea pig alpha 1-microglobulin (alpha 1-m) was found to exert mitogenic effects on guinea pig lymphocytes, i.e. peritoneal exudate lymphocytes (PEL) or T lymphocytes from regional or mesenteric lymph nodes (LNL). On the other hand, spleen T lymphocytes did not respond to alpha 1-m. Stimulation of LNL required the pr...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb02173.x

    authors： Lögdberg L,Akerström B,Shevach EM

    更新日期：1986-11-01 00:00:00