Activation of human neutrophils induced by immune complexes prepared with cationic and anionic fractions of normal IgG antibodies.

Abstract:

:The authors have recently shown that the ability of immune complexes (IC) to trigger Fc gamma R-dependent cell responses can be dramatically enhanced when the isoelectric point (pI) of normal IgG antibodies is increased from 5.8-8.5 to 8.5-9.8 by treatment with 1-ethyl-3-2(3-dimethylaminopropyl) carbodiimide HCl and ethylene diamine. In the current work the authors analyse whether differences in the charge of normal IgG antibodies may also affect IC activity. Soluble IC (sIC) were prepared with (a) rabbit IgG antibodies to human IgG and anionic or cationic fractions of human IgG; and (b) bovine serum albumin (BSA) and anionic or cationic fractions of rabbit IgG anti-BSA antibodies. Similar abilities to bind to neutrophil surface were observed for sIC prepared with both anionic (anIC) and cationic fractions of IgG (catIC). Moreover, no differences were found when neutrophil shape change, chemiluminescence (CL) emission and elastase release were induced by either anIC or catIC. As in the case of sIC, particulate IC prepared with erythrocytes (E) and anionic or cationic fractions of specific IgG antibodies (IgG-E) showed no differences in their abilities to trigger either CL emission or ADCC. Taken together, these results suggest that the pI of normal IgG antibodies do not affect the ability of IC to trigger neutrophil responses mediated by receptors for the Fc portion of IgG antibodies (Fc gamma R).

journal_name

Scand J Immunol

authors

Trevani AS,Andonegui G,Kempfer C,Malchiodi E,Geffner JR

doi

10.1046/j.1365-3083.1996.d01-40.x

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

341-4

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

43

pub_type

杂志文章
  • T-cell cross-reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors.

    abstract::The therapeutic use of the immune system to specifically attack tumours has been a long-standing vision among tumour immunologists. Recently, the use of checkpoint inhibitors to turn-off immunosuppressive signals has proven to be effective in enhancing T-cell reactivity against patient-specific neoantigens, resulting ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1111/sji.12643

    authors: Sioud M

    更新日期:2018-03-01 00:00:00

  • Neutralization susceptibility of B subtype variant B" primary HIV-1 isolates. The HEC/FIOCRUZ AIDS Clinical Research Group.

    abstract::Susceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates belonging to subtype B, to the B"-variant of subtype B or to subtype F from infected individuals residing in Rio de Janeiro was assayed. A lower infectivity of the B"- and F isolates when compared to t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.1998.00345.x

    authors: Bongertz V,Costa CI,Guimarães ML,Grinsztejn B,João Filho EC,Galvão-Castro B,Morgado MG

    更新日期:1998-06-01 00:00:00

  • Participation of V beta 4(+)-, V beta 7(+)-, and V beta 11(+)-T lymphocytes in haematogenously acquired Staphylococcus aureus nephritis.

    abstract::The most frequent pathogen in haematogenously acquired kidney infections in humans in Staphylococcus aureus. In order to characterize in situ the immunological patterns of septic nephritis we developed a murine model of this disease. A single intravenous injection of S. aureus producing toxic shock syndrome toxin-1 re...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.1996.d01-309.x

    authors: Verba V,Tarkowski A

    更新日期:1996-09-01 00:00:00

  • Cellular fibronectin in rheumatoid synovium and synovial fluid: a possible factor contributing to lymphocytic infiltration.

    abstract::Mouse monoclonal antibodies against ED sequence-containing cellular fibronectin (cFn) were used to show that Fn in the inflamed synovium is distinct from the major form of plasma Fn (pFn). An accumulation of cFn was seen at sites of hyperplasia of the rheumatoid synovial membrane and in the walls of small vessels in t...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1990.tb02802.x

    authors: Walle TK,Vartio T,Helve T,Virtanen I,Kurki P

    更新日期:1990-04-01 00:00:00

  • Intranasal co-delivery with the mouse zona pellucida 3 and GM-CSF expressing constructs enhances humoral immune responses and contraception in mice.

    abstract::Granulocyte-monocyte colony-stimulating factor (GM-CSF) regulates the function of antigen-presenting cells (APCs) and has been broadly used as the adjuvant. Here, we tested whether intranasal delivery of GM-CSF can improve the contraception of mouse zona pellucida 3 (mZP3) DNA vaccine. Our results showed that co-admin...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2012.02765.x

    authors: Ma X,Li J,Zhang F

    更新日期:2012-12-01 00:00:00

  • Quantitation of cells secreting immunoglobulins after elution from rheumatoid synovial tissue.

    abstract::Mononuclear cells (MNC) eluted from rheumatoid synovial tissue of 16 patients with rheumatoid arthritis were examined for immunoglobulin-secreting cells (ISC). Immediately after elution and separation synovial tissue MNC contained considerable numbers of ISC. IgG and IgA ISC were more abundant than IgM ISC. At the sam...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1982.tb00741.x

    authors: Egeland T,Lea T,Mellbye OJ,Pahle JA,Ottesen T,Natvig JB

    更新日期:1982-11-01 00:00:00

  • Inhibitory effect of haptoglobin on granulocyte chemotaxis, phagocytosis and bactericidal activity.

    abstract::Human haptoglobin (Hp) is synthesized at hepatic and extrahepatic sites as an acute-phase reactant protein (APP). We investigated the effects of Hp on granulocyte function. The chemotaxis of freshly isolated human granulocytes and differentiated HL-60 cells in response to the bacterial tripeptide, f-met-leu-phe, was i...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.1999.00609.x

    authors: Rossbacher J,Wagner L,Pasternack MS

    更新日期:1999-10-01 00:00:00

  • Upregulated microRNA-132 in T helper 17 cells activates hepatic stellate cells to promote hepatocellular carcinoma cell migration in vitro.

    abstract::MicroRNAs play an important role in the modulation of the immune system. T helper 17 (Th17) cells are involved in the modulation of the tumour microenvironment. However, the function of miRNA in Th17 cells in the tumour microenvironment is unclear. In this study, we analysed miR-132 expression in Th17 cells and assess...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.13007

    authors: Feng R,Cui Z,Liu Z,Zhang Y

    更新日期:2020-12-02 00:00:00

  • Inhibitory activity of soluble IL-2R in sera, ascites and culture supernatants from murine leukaemic cells.

    abstract::The effect of sera from mice bearing a T cell lymphoid leukaemia (LB) and the supernatants from short term cultures of the tumour cells were studied on cell proliferation using syngeneic and allogeneic normal and tumour cells. An inhibitory activity was demonstrated in 24-48 h supernatants of LB cells in culture and d...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1994.tb03467.x

    authors: Waldner C,Mongini C,Alvarez E,Roig I,Hajos SE

    更新日期:1994-09-01 00:00:00

  • A low serum concentration of mannan-binding protein is not associated with serogroup B or C meningococcal disease.

    abstract::The mammalian C-type serum lectin, mannan-binding protein (MBP), may induce C1q- and antibody-independent activation of the classical pathway of complement. Accordingly, MBP is considered as a member of the complement system. Complement deficiencies have been found with increased frequency in patients with meningococc...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1993.tb03320.x

    authors: Garred P,Michaelsen TE,Bjune G,Thiel S,Svejgaard A

    更新日期:1993-04-01 00:00:00

  • IgM and IgG subclass distribution of human anti-Ro/SSA 60 kDa autoantibodies.

    abstract::The Ro/SSA and La/SSB antigens are common targets for autoantibodies found in the sera of patients with Sjögren's syndrome and SLE. The anti-Ro/SSA and anti-La/SSB antibodies often appear together but are not cross-reactive. This paper describes the humoral autoimmune response to the Ro/SSA 60 kDa protein moiety with ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1994.tb03357.x

    authors: Wahren M,Ringertz NR,Pettersson I

    更新日期:1994-02-01 00:00:00

  • Selective response of dermal Th-1 cells to 20-50 kDa streptococcal cell-wall proteins in chronic plaque psoriasis.

    abstract::We have recently described a dermal Th-1 subset in skin lesions of psoriasis which recognizes cell-wall extract isolated from group A streptococci (GAS). As a first step in the identification of the streptococcal proteins involved, dermal T-cell lines (TCL) cultured from the lesional skin of 12 human leucocyte antigen...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.2003.01309.x

    authors: Baker BS,Ovigne JM,Fischetti VA,Powles A,Fry L

    更新日期:2003-09-01 00:00:00

  • Complement receptors in human renal glomeruli.

    abstract::Glomeruli in Cryostat sections of foetal and adult renal tissues adsorbed sheep erythrocytes sensitized with IgM antibody and human or mouse complement (EAC). Activated complement was essential for the reaction to occur. The receptor had specificity for the C3b fragment of C3 and is probably of protein or glycoprotein...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1976.tb00298.x

    authors: Matre R,Tönder O

    更新日期:1976-01-01 00:00:00

  • The major histocompatibility complex haplotypes dictate and the background genes fine-tune the dominant versus the cryptic response profile of a T-cell determinant within a native antigen: relevance to disease susceptibility and vaccination.

    abstract::The immune system of a healthy individual responds vigorously to foreign microbial antigens. However, all potentially immunogenic regions (determinants) within an antigen are not functionally of equal relevance in mediating host immunity against the pathogen. Moreover, some of these antigenic determinants are well pro...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2006.01891.x

    authors: Sinha P,Snyder JA,Kim EY,Moudgil KD

    更新日期:2007-02-01 00:00:00

  • Fentanyl Suppresses the Survival of CD4+ T Cells Isolated from Human Umbilical Cord Blood through Inhibition of IKKs-mediated NF-κB Activation.

    abstract::The aim of this study was to investigate the effects and the underlying mechanisms of fentanyl anaesthetic on T lymphocytes isolated from human umbilical cord blood in vitro. The percentages of CD4+ , CD8+ and regulatory T (Treg) cells in human umbilical cord blood mononuclear cells (UBMC) treated with fentanyl in vit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12538

    authors: Ma K,Ma P,Lu H,Liu S,Cao Q

    更新日期:2017-05-01 00:00:00

  • Interleukin-17 facilitates the immune suppressor capacity of high-grade glioma-derived CD4 (+) CD25 (+) Foxp3 (+) T cells via releasing transforming growth factor beta.

    abstract::High-grade glioma is a malignant tumour; the pathogenesis is to be further investigated. Interleukin (IL)-17 is an inflammatory cytokine. Chronic inflammation is a pathological feature of cancer. This study aimed to characterize the glioma-derived IL-17(+) regulatory T cells (Treg). In this study, single cells were is...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12185

    authors: Liang H,Yi L,Wang X,Zhou C,Xu L

    更新日期:2014-08-01 00:00:00

  • Hypothesis for the control of clotting factor VIII inhibitory antibodies by decreasing potency of helper T-cell-recognized epitopes in factor VIII.

    abstract::The study of the immunobiology of FVIII inhibitors may lead to new therapies for this potentially severe complication of haemophilia A and to new principles for the use of therapeutic proteins. In order to characterize the idiotype-anti-idiotype networks regulating FVIII inhibitors, we developed rabbit anti-idiotypic ...

    journal_title:Scandinavian journal of immunology

    pub_type: 社论,评审

    doi:10.1111/j.1365-3083.1992.tb03125.x

    authors: Tiarks C,Humphreys RE,Anderson J,Mole J,Pechet L

    更新日期:1992-11-01 00:00:00

  • Avidity of serogroup A meningococcal IgG antibodies after immunization with different doses of a tetravalent A/C/Y/W135 polysaccharide vaccine.

    abstract::In the absence of an affordable conjugate meningococcal vaccine, mass vaccination campaigns with polysaccharide vaccines are the means to control meningitis epidemics in sub-Saharan Africa. Facing global vaccine shortage, the use of reduced doses, which have been shown to be protective by serum bactericidal activity, ...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2011.02535.x

    authors: Bårnes GK,Naess LM,Rosenqvist E,Guerin PJ,Caugant DA,Fractional Doses Vaccine Study Group.

    更新日期:2011-07-01 00:00:00

  • Human autologous monocytes and monocyte-derived macrophages in co-culture with carcinoma F-spheroids secrete IL-6 by a non-CD14-dependent pathway.

    abstract::The secretion of interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF)-alpha were compared when freshly isolated autologous monocytes or monocytederived macrophages (MDMs) were co-cultured in vitro with autologous fragment (F)-spheroids established from a series of head and neck squamous cell carcinoma (HNSCC...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-3083.2001.00853.x

    authors: Heimdal JH,Aarstad HJ,Olsnes C,Olofsson J

    更新日期:2001-02-01 00:00:00

  • Imbalance of the CD4+ subpopulations expressing CD45RA and CD29 antigens in the peripheral blood of adults and children with Down syndrome.

    abstract::Peripheral blood lymphoid subsets expressing either CD45RA or CD29 antigens, were quantified in 30 children and 59 adults with Down Syndrome and appropriate age-matched controls, by dual immunofluorescence and flow cytometry. Down's patients, both adults and children, displayed a significant decrease of CD4+CD45RA+ ce...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1993.tb01733.x

    authors: Barrena MJ,Echaniz P,Garcia-Serrano C,Cuadrado E

    更新日期:1993-10-01 00:00:00

  • B- and T-cell-specific alloantigens in man.

    abstract::Screening for B-cell-specific antibodies in unabsorbed pregnancy sera preselected for weak reactivity in regular HLA-A, -B, and -C screening yielded a relatively high proportion (35/81) of B-cell-specific antibodies. Most B-cell-specific antibodies react broadly, showing inclusion phenomena suggesting 'cross-reactivit...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1977.tb02099.x

    authors: Albert ED,Andreas A,McNicholas A,Scholtz S,Kuntz B

    更新日期:1977-01-01 00:00:00

  • Role of calcium channels in congenital heart block.

    abstract::Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children req...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-3083.2010.02439.x

    authors: Karnabi E,Boutjdir M

    更新日期:2010-09-01 00:00:00

  • Difference in the effect of immobilized ligands on the Fc and C3 receptors of mouse peritoneal macrophages in vitro.

    abstract::The function of the Fc and C3 receptors on the free surface of normal and endotoxin activated mouse peritoneal macrophages seeded on glass bound antibody--antigen (AbAg) complexes or complement was examined. We found that the glass bound AbAg complexes interfered with attachment and internalization of particles recogn...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1978.tb00422.x

    authors: Kaplan G,Eskeland T,Seljelid R

    更新日期:1978-01-01 00:00:00

  • Properties of cell subpopulations of starfish axial organ: in vitro effect of pokeweed mitogen and evidence of lymphokine-like substances.

    abstract::The in vitro effects of pokeweed mitogen (PWM) on axial organ (AO) cells of the echinoderm starfish Asteria rubens have been studied. PWM stimulates 3H-thymidine incorporation by the whole population of AO cells (index of stimulation 4-5). On the basis of surface adherence to nylon wool the AO cell population can be f...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1981.tb00565.x

    authors: Leclerc M,Brillouet C,Luquet G,Agogue P,Binaghi RA

    更新日期:1981-09-01 00:00:00

  • IL-23 Activated γδ T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL-21 in Children with Primary Nephrotic Syndrome.

    abstract::This study (1) analysed the percentage of γδ T cells, γδ T cell subsets, Th17 cells and regulatory T cells (Treg cells) and (2) determined the role of IL-23 in primary nephrotic syndrome (PNS) patients with active disease and in remission. Eighty-four patients with PNS and 51 healthy age-matched controls were included...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/sji.12629

    authors: Zhang L,Yan J,Yang B,Zhang G,Wang M,Dong S,Liu W,Yang H,Li Q

    更新日期:2018-01-01 00:00:00

  • Mechanisms whereby lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes.

    abstract::During immunological rejection of the transplanted heart, cytotoxic T lymphocytes (CTL) infiltrate the myocardium and by damaging the myocytes contribute to loss of function. To address one important aspect of heart transplant rejection, we investigated in guinea pig ventricular myocytes how CTL-derived lytic granules...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1993.tb01664.x

    authors: Binah O,Kline R,Berke G,Hoffman B

    更新日期:1993-01-01 00:00:00

  • Role of B cells in the expression of the PPD response of human lymphocytes in vitro.

    abstract::Human blood lymphocytes were tested for their proliferative response to purified protein derivative (PPD) in vitro. Purified T cells showed a lower response than the orginial purified lymphocyte suspension. Purified B cells were unresponsive to PPD. Mixtures of preparations of T and B cells were stimulated to a greate...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1975.tb02655.x

    authors: Blomgren H

    更新日期:1975-09-01 00:00:00

  • Interleukin-2-activated natural killer cells may have a direct role in the control of Leishmania (Leishmania) amazonensis promastigote and macrophage infection.

    abstract::To study the role of Natural Killer (NK) cells in Leishmania infection, peritoneal macrophages from BALB/c mice were infected with Leishmania (Leishmania) amazonensis promastigotes and incubated with interleukin-2 (IL-2)-activated NK (A-NK) cells at different ratios of A-NK cells to infected macrophages (5:1, 1:1, 0.2...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.2005.01681.x

    authors: Aranha FC,Ribeiro U Jr,Basse P,Corbett CE,Laurenti MD

    更新日期:2005-10-01 00:00:00

  • Immunological characterization of novel secreted antigens of Mycobacterium tuberculosis.

    abstract::Proteins secreted by Mycobacterium tuberculosis are targets of host immune responses and as such are investigated for vaccine and immunodiagnostics development. Computer-driven searches of the M. tuberculosis H37Rv genome had previously identified 45 novel secreted proteins. Here, we report the characterization of the...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.0300-9475.2005.01557.x

    authors: Ben Amor Y,Shashkina E,Johnson S,Bifani PJ,Kurepina N,Kreiswirth B,Bhattacharya S,Spencer J,Rendon A,Catanzaro A,Gennaro ML

    更新日期:2005-02-01 00:00:00

  • Detection of tumour-associated transplantation antigens by syngeneic cytotoxic T lymphocytes after fusion of tumour cell membrane vesicles to recipient cells.

    abstract::Sendai virus envelope-mediated fusion was used to transfer plasma membrane vesicles of ESb lymphoma cells (H-2d) to syngeneic or allogeneic recipient cells. After fusion, ESb-specific cell surface determinants were detectable on the recipient cells, as revealed by indirect immunofluorescence and cytofluorographic anal...

    journal_title:Scandinavian journal of immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-3083.1984.tb01000.x

    authors: Altevogt P

    更新日期:1984-09-01 00:00:00