当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF IMMUNOLOGY期刊下所有文献 > Kinetics of cytokine release and expression of lymphocyte cell-surface activation markers after in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae.

Kinetics of cytokine release and expression of lymphocyte cell-surface activation markers after in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae.

Abstract：

:The aim of this study was to describe the kinetics of the cytokine release and the expression of activation markers on lymphocytes after stimulation of peripheral blood mononuclear cells (PBMC) with whole killed Streptococcus pneumoniae. The cytokine release and the expression of CD25 and HLA-DR on T cells, and CD69 on T cells, B cells and NK cells, were measured at different times. Our results show that tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-10 and IL-12 reached maximal levels at 24 h, while IL-6, IL-8, TNF-beta and interferon (IFN)-gamma increased throughout the 1-week test period. The strains tested gave an increased expression of CD69 on all cell types, as well as an increase of CD25 and HLA-DR expression on T cells. The maximal CD69 expression was seen after 24 h on T cells and NK cells, while the B-cell expression of CD69 reached a plateau at the same time. All the cells still expressed CD69 on their surfaces after 1 week. In conclusion the results indicate that there was probably an early activation of monocytes leading to a polyclonal activation of lymphocytes.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Arvå E,Andersson B

doi

10.1046/j.1365-3083.1999.00470.x

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

237-43

issue

3

eissn

0300-9475

issn

1365-3083

journal_volume

49

pub_type

杂志文章

相关文献

SCANDINAVIAN JOURNAL OF IMMUNOLOGY文献大全
  • IFNγ and perforin cooperate to control infection and prevent fatal pathology during persistent gammaherpesvirus infection in mice.

    abstract：:Infection with murine gammaherpesvirus 68 has become an accepted model for studying the virus/host interactions with regard to gammaherpesvirus infections. Previous studies using gene-deficient mice have revealed that neither IFNγ nor perforin is essential in controlling the outcome of infection or the virus load duri...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.12176

    authors： Bartholdy C,Høgh-Petersen M,Storm P,Holst PJ,Orskov C,Christensen JP,Thomsen AR

    更新日期：2014-06-01 00:00:00

  • Virus elimination in acute lymphocytic choriomeningitis virus infection. Correlation with virus-specific delayed-type hypersensitivity rather than cytotoxicity.

    abstract：:The immunological effector mechanism responsible for the elimination of virus in murine acute non-fatal extracranial lymphocytic choriomeningitis virus infection was studied. In this infection virus clearance is generally regarded as the result of a direct action of virus-specific cytotoxic T cells (Tc cells) on virus...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1983.tb00816.x

    authors： Thomsen AR,Volkert M,Bro-Jørgensen K

    更新日期：1983-06-01 00:00:00

  • Variation in gut-homing CD27-negative lymphocytes in inflammatory colon disease.

    abstract：:Prolonged antigenic stimulation results in lymphocyte shedding of CD27, a member of the tumour necrosis factor receptor (TNFR) family, and transformation to a stable phenotype capable of synthesizing interleukin-4 (IL-4). Co-expression of alpha4beta7 identifies those cells with gut-homing potential. We have investigat...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00387.x

    authors： Meenan J,Spaans J,Grool TA,Lammers K,Pals S,Tytgat GN,van Deventer SJ

    更新日期：1998-09-01 00:00:00

  • Isolation and partial characterization of a murine cell surface glycoprotein with affinity for exogenously added beta 2-microglubulin.

    abstract：:Exogenously added beta 2-microglobulin (beta 2m) binds to a variety of murine cell types. The 'receptor' for beta 2m has been isolated. The purified 'receptor' comprised a 48,000-dalton chain and occasionally a 25,000-dalton component. Direct crosslinking of beta 2m to the receptor on intact cells gave rise to a singl...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1980.tb00014.x

    authors： Sege K,Peterson PA

    更新日期：1980-01-01 00:00:00

  • Vaccination against Helicobacter pylori in non-human primate models and humans.

    abstract：:Several vaccination studies have been performed in monkeys and humans testing the feasibility of prophylactic and therapeutic immunizations against Helicobacter pylori. The monkey studies showed that immune responses were induced by oral vaccination with the mucosal adjuvant LT (Escherichia coli heat-labile enterotoxi...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-3083.2001.00911.x

    authors： Lee CK

    更新日期：2001-05-01 00:00:00

  • Roles of group IIA phospholipase A2 and complement in killing of bacteria by acute phase serum.

    abstract：:The complement system is regarded as an important component of the innate defence system against invading bacteria. However, synergistic actions between the complement and the other components of innate immunity are incompletely known. Human group IIA phospholipase A(2) (hGIIA PLA(2)) is an effective antibacterial enz...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2005.01678.x

    authors： Grönroos JO,Salonen JH,Viander M,Nevalainen TJ,Laine VJ

    更新日期：2005-10-01 00:00:00

  • Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels.

    abstract：:The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primar...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2004.01409.x

    authors： Carvalho LJ,Oliveira SG,Theisen M,Alves FA,Andrade MC,Zanini GM,Brígido MC,Oeuvray C,Póvoa MM,Muniz JA,Druilhe P,Daniel-Ribeiro CT

    更新日期：2004-04-01 00:00:00

  • Reactivity patterns of synovial T-cell lines derived from a patient with rheumatoid arthritis. I. Reactions with defined antigens and auto-antigens suggest the existence of multireactive T-cell clones.

    abstract：:The functional T-cell repertoire in the inflamed joint of a patient with rheumatoid arthritis was analysed at the clonal level. Using limiting dilution techniques and selecting for growth of in vivo activated and/or autoreactive T cells, 149 T-cell lines were established. They were tested in a proliferation assay for ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1997.d01-105.x

    authors： Melchers I,Jooss-Rüdiger J,Peter HH

    更新日期：1997-08-01 00:00:00

  • Density distribution profiles of T cells: TM, TG and TA cells and response patterns in autologous versus allogeneic MLRs.

    abstract：:Discontinuous Percoll gradients have been used to obtain selected human peripheral blood T lymphocytes without having to resort to interactions with immune complexes in the fractionation of Tm, Tg and Ta cells. Here, we could show that Ta cells represent a heterogeneous population with no distinct density profile, in ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1982.tb00719.x

    authors： Canonica GW,Kabelitz D,Sjöberg O,Aigrain Y,Wigzell H

    更新日期：1982-09-01 00:00:00

  • Transcriptional regulation of serum amyloid A1 gene expression in human aortic smooth muscle cells involves CCAAT/enhancer binding proteins (C/EBP) and is distinct from HepG2 cells.

    abstract：:Regulation of acute-phase serum amyloid A (A-SAA) synthesis by proinflammatory cytokines and steroid hormones in human aortic smooth muscle cells (HASMCs) is distinct from that in HepG2 cells. To study the cis- and trans-activating promoter element involved in the SAA1 gene expression by HASMCs and HepG2 cells, we con...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2002.01169.x

    authors： Kumon Y,Suehiro T,Faulkes DJ,Hosakawa T,Ikeda Y,Woo P,Sipe JD,Hashimoto K

    更新日期：2002-11-01 00:00:00

  • Inhibition of de novo IgM antibody synthesis by thalidomide as a relevant mechanism of action in leprosy.

    abstract：:Thalidomide is well documented to be an effective treatment for erythema nodosum leprosum (ENL) occurring in lepromatous leprosy. To be beneficial, thalidomide must interfere with one or more of the several essential steps in the pathogenesis of this syndrome, which is presumed to be a clinical manifestation of an Art...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1981.tb00169.x

    authors： Shannon EJ,Miranda RO,Morales MJ,Hastings RC

    更新日期：1981-01-01 00:00:00

  • Immunoglobulin G complexes without sialic acids enhance osteoclastogenesis but do not affect arthritis-mediated bone loss.

    abstract：:Immunoglobulin G (IgG) is important in clearance and recognition of previously presented antigens and after activation, IgGs can interact with the Fc gamma receptors (FcγRs) on haematopoietic cells, including bone-resorbing osteoclasts. The pathogenicity of IgG, that is the ability to elicit stimulatory effects via Fc...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/sji.13009

    authors： Sehic E,Westerlund A,Lagerquist MK,Lerner UH,Carlsten H,Henning P,Engdahl C

    更新日期：2020-12-15 00:00:00

  • Effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) on rat thymocytes.

    abstract：:The short-term incubation of rat thymocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a significant increase in sialyltransferase (S-T) activity and a decrease in terminal deoxyribonucleotidyl transferase (TdT) activity. The ratio of peanut agglutinin (PNA)-positive cells and of TdT-positive cells in...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1989.tb01148.x

    authors： Sasaki R,Takaku F,Miura Y

    更新日期：1989-04-01 00:00:00

  • Regulation of interleukin-6 production in human fetal Kupffer cells.

    abstract：:Inflammatory mediators such as interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) exhibit local autocrine and paracrine effects as well as distant systemic effects on target cells. Human Kupffer cells, the fixed tissue macrophages of the liver, may modulate immune and en...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02532.x

    authors： Kutteh WH,Rainey WE,Carr BR

    更新日期：1991-05-01 00:00:00

  • Proliferative kinetics, phenotype and cytotoxic function of thymic and peripheral T-cell colonies.

    abstract：:Cells produced in murine T-cell colonies grown in methylcellulose have been studied to evaluate their proliferation, phenotypic differentiation, and ability to give rise to cytotoxic cells. Colony-forming cells from presumably cortical or medullary thymocytes, separated by peanut agglutination, or from lymph nodes, sh...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1986.tb01963.x

    authors： Röpke C,Claësson MH

    更新日期：1986-02-01 00:00:00

  • Imbalance of the CD4+ subpopulations expressing CD45RA and CD29 antigens in the peripheral blood of adults and children with Down syndrome.

    abstract：:Peripheral blood lymphoid subsets expressing either CD45RA or CD29 antigens, were quantified in 30 children and 59 adults with Down Syndrome and appropriate age-matched controls, by dual immunofluorescence and flow cytometry. Down's patients, both adults and children, displayed a significant decrease of CD4+CD45RA+ ce...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1993.tb01733.x

    authors： Barrena MJ,Echaniz P,Garcia-Serrano C,Cuadrado E

    更新日期：1993-10-01 00:00:00

  • Human B cells and macrophages cooperate in T-cell-independent type 2 response.

    abstract：:We have analysed separately the role of B-cell receptor (BCR) stimulation and the soluble second signal in the T-cell-independent type 2 (TI-2) B-cell response. We were able to show that human B cells and macrophages (Mphi) could function together in TI-type microbial response. Interestingly, BCR cross-linking of peri...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2007.02057.x

    authors： Mättö M,Raunio AR,Postila V,Huttunen K,Hirvonen MR,Pelkonen J

    更新日期：2008-03-01 00:00:00

  • Human serum amyloid P component binds to peripheral blood monocytes.

    abstract：:The binding of human serum amyloid P component (SAP) to blood cells and monocyte-derived dendritic cells was investigated by flow cytometry. Monocytes bound biotinylated SAP with avidity in a dose-dependent and saturable manner. By contrast, the binding of SAP to monocyte-derived dendritic cells was weak. No binding t...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2006.01774.x

    authors： Macdonald SL,Kilpatrick DC

    更新日期：2006-07-01 00:00:00

  • The Clinical Relevance of Antifibrillarin (anti-U3-RNP) Autoantibodies in Systemic Sclerosis.

    abstract：:Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifibrillarin autoantibodies (AFA) in patients with SSc. The clinical features of 3...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/sji.12510

    authors： Tall F,Dechomet M,Riviere S,Cottin V,Ballot E,Tiev KP,Montin R,Morin C,Chantran Y,Grange C,Jullien D,Ninet J,Chretien P,Cabane J,Fabien N,Johanet C

    更新日期：2017-01-01 00:00:00

  • Bromelain treatment leads to maturation of monocyte-derived dendritic cells but cannot replace PGE2 in a cocktail of IL-1β, IL-6, TNF-α and PGE2.

    abstract：:Immunotherapy using dendritic cells (DC) has shown promising results. However, the use of an appropriate DC population is critical for the outcome of this treatment, and the search for an optimal DC subset is still ongoing. The DC used in immunotherapy today are usually matured with a cytokine cocktail consisting of T...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2011.02562.x

    authors： Karlsen M,Hovden AO,Vogelsang P,Tysnes BB,Appel S

    更新日期：2011-08-01 00:00:00

  • Induction of cytotoxic T-cell activity by the protective antigen of Schistosoma mansoni Sm28GST or its derived C-terminal lipopeptide.

    abstract：:In a previous work the authors demonstrated that immunization with Schistosoma mansoni 28-kDa glutathione-S-transferase (Sm28GST) was able to reduce hepatic damage in infected mice and that the adoptive transfer of Sm28GST-specific T cells reproduced the protective effect obtained with the recombinant molecule. In the...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1996.d01-340.x

    authors： Pancré V,Gras-Masse H,Delanoye A,Herno J,Capron A,Auriault C

    更新日期：1996-11-01 00:00:00

  • Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition.

    abstract：:Coeliac disease probably results from a T-cell response to wheat gliadin and is associated to HLA-DQ2. No gliadin epitopes recognized by intestinal T cells have yet been identified, limiting our understanding of the pathogenesis. Gut-lesion-derived DQ2-restricted T cells from coeliac disease patients were used to iden...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1998.00397.x

    authors： Sjöström H,Lundin KE,Molberg O,Körner R,McAdam SN,Anthonsen D,Quarsten H,Norén O,Roepstorff P,Thorsby E,Sollid LM

    更新日期：1998-08-01 00:00:00

  • The influence of low oxygen on macrophage response to Leishmania infection.

    abstract：:Hypoxia (low oxygen tension) is a common feature of inflamed and infected tissues. The influence of hypoxia on macrophage responses to micro-organisms has only recently been studied. This study demonstrates that hypoxia induced macrophages to control Leishmania amazonensis, an intracellular parasite that causes cutane...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.2011.02566.x

    authors： Degrossoli A,Arrais-Silva WW,Colhone MC,Gadelha FR,Joazeiro PP,Giorgio S

    更新日期：2011-08-01 00:00:00

  • Recombinant human interleukin-8 restores function in neutrophils from patients with myelodysplastic syndromes without stimulating myeloid progenitor cells.

    abstract：:Prognosis in myelodysplastic syndrome (MDS) is not only correlated closely with blast cell count in bone marrow and chromosomal abnormalities but also correlated with decreased leucocyte count and function leading to acquisition of lethal infections. Recently, clinical trials in MDS have focused on the application of ...

    journal_title：Scandinavian journal of immunology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-3083.1993.tb02560.x

    authors： Zwierzina H,Holzinger I,Gaggl S,Wolf H,Schöllenberger S,Lam C,Bammer T,Geissler D,Lindley I

    更新日期：1993-03-01 00:00:00

  • Hidden rheumatoid factor and Wa idiotype expression in juvenile rheumatoid arthritis.

    abstract：:The major rheumatoid factor cross-reactive idiotype, which was defined by prototypic monoclonal IgM rheumatoid factors from Waldenstrom's macroglobulinaemia patient Wa, is present on 60% of all monoclonal IgM RF paraproteins. One-third of patients with juvenile rheumatoid arthritis (JRA), who are seronegative for clas...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb01568.x

    authors： Ilowite NT,Wedgwood JF,Moore TL,Ramakrishnan T,Bonagura VR

    更新日期：1991-10-01 00:00:00

  • Origin and immunoregulation of autoantibodies against intestinal alkaline phosphatase.

    abstract：:In the sera of patients with acute bacterial infections specific autoantibodies (sIAPa) of the immunoglobulin class G (IgG) were found which bind to intestinal alkaline phosphatase (IAP) through the Fab portion. This was demonstrated using immunoaffinity (IA) isolation of sIAPa from patients' sera (particularly bacter...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1995.tb03586.x

    authors： Kolbus N,Beuche W,Schlaf G,Nüsslein HG,Felgenhauer K,Mäder M

    更新日期：1995-04-01 00:00:00

  • Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins.

    abstract：:Psoriasis is a T-cell mediated inflammatory skin disease which has been associated with group A, beta-haemolytic streptococcal infections. Four 20 a.a. long M6-peptides sharing 5-6 a.a. sequences with human epidermal keratins were identified. To investigate the role of potentially cross-reactive T cells in the pathoge...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.1997.d01-438.x

    authors： Sigmundsdottir H,Sigurgeirsson B,Troye-Blomberg M,Good MF,Valdimarsson H,Jonsdottir I

    更新日期：1997-06-01 00:00:00

  • Quantification of cytokine gene expression using an economical real-time polymerase chain reaction method based on SYBR Green I.

    abstract：:Assessment of cytokine expression has become crucial to understand host responses to infections as well as autoimmunity. Several approaches including Northern blot, RNase protection assay and enzyme-linked immunosorbent assay have been used for this purpose, but they are time consuming, labour intense, and relatively ...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-3083.2003.01250.x

    authors： Ramos-Payán R,Aguilar-Medina M,Estrada-Parra S,González-Y-Merchand JA,Favila-Castillo L,Monroy-Ostria A,Estrada-Garcia IC

    更新日期：2003-05-01 00:00:00

  • Defective Candida opsonin and procidin function in patients with recurrent pyogenic infection: a common immunodeficiency.

    abstract：:Polymorphonuclear cell function tests were performed in 340 patients with recurrent unexplained infections. Serum-dependent defects in phagocytosis and intracellular killing of Candida albicans (Candida opsonin and procidin defects) were specifically associated with susceptibility to recurrent pyogenic infections, Can...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-3083.1991.tb02495.x

    authors： Parkin JM,Bridges J,Sloper KS,Warner JO,Pinching AJ

    更新日期：1991-01-01 00:00:00

  • Dietary antigen-specific T-cell responses: switch from an interleukin-10-dominated response in normal mice to a T-helper 1 cytokine profile in Galphai2-deficient mice prior to colitis.

    abstract：:We investigated dietary antigen-specific T-cell responses in mesenteric lymph nodes (MLN) and Peyer's patches (PP) in noncolitic control mice as well as in colitis-prone mice prior to onset of histological active colitis. T cells were restimulated in vitro with constituents isolated from the mouse diet. Interestingly,...

    journal_title：Scandinavian journal of immunology

    pub_type： 杂志文章

    doi：10.1111/j.0300-9475.2005.01535.x

    authors： Bjursten M,Hultgren Hörnquist E

    更新日期：2005-01-01 00:00:00