Abstract：
:Prolonged antigenic stimulation results in lymphocyte shedding of CD27, a member of the tumour necrosis factor receptor (TNFR) family, and transformation to a stable phenotype capable of synthesizing interleukin-4 (IL-4). Co-expression of alpha4beta7 identifies those cells with gut-homing potential. We have investigated these cell populations in patients with inflammatory colonic disease. Circulating and lamina propria mononuclear cells were isolated from patients with Crohn's disease (CD), ulcerative colitis (UC), non-inflammatory bowel disease (non-IBD) colonic inflammation and healthy controls. Double and triple colour flow cytometry for CD3, CD4, CD27, alpha4beta7 and intracellular cytokines was performed. Circulating CD4+ CD27- populations were increased in patients with CD (8.8 +/- 0.8%, P < 0.001), UC (12.2 +/- 1.9%, P < 0.001) and non-IBD colitis (10.5 +/- 1.3%, P < 0.01) as compared with controls (6.1 +/- 0.5%). CD4+ CD27- alpha4beta7+ cells were increased in CD (P < 0.01). Lamina propria CD4+ CD27- populations were depressed significantly in CD (P < 0.05), UC (P < 0.02) and non-IBD colitis (P < 0.03). Mucosal CD4+ CD27- cells synthesized IL-4 in preference to interferon-gamma. Thus, colonic inflammation is associated with alterations in gut-tropic circulating and mucosal populations of differentiated memory T cells with the phenotype of predominantly IL-4-synthesizing cells.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Meenan J,Spaans J,Grool TA,Lammers K,Pals S,Tytgat GN,van Deventer SJdoi
10.1046/j.1365-3083.1998.00387.xsubject
Has Abstractpub_date
1998-09-01 00:00:00pages
318-23issue
3eissn
0300-9475issn
1365-3083journal_volume
48pub_type
杂志文章abstract：:Natural killer (NK) cells form part of the vertebrate defence against viruses and tumours, but show only limited specificity. The molecule(s) recognized by NK cells on target cells are at present unknown. Major histocompatibility complex (MHC) class I antigen concentration on target cells is inversely correlated with ...
journal_title：Scandinavian journal of immunology
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doi：10.1111/j.1365-3083.1989.tb01184.x
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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doi：10.1111/j.1365-3083.2012.02704.x
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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abstract：:F protein is of unknown function and found principally in the liver, with smaller amounts detectable by gel diffusion and immunostaining in kidney and brain. By taking advantage of a newly developed radioimmunoassay, capable of detecting down to 1 ng ml-1 of F protein, the organ distribution of this molecule in the mo...
journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1988.tb02357.x
更新日期：1988-03-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1976.tb03048.x
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1980.tb00040.x
更新日期：1980-01-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
doi：10.1111/j.1365-3083.1975.tb02640.x
更新日期：1975-01-01 00:00:00
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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journal_title：Scandinavian journal of immunology
pub_type： 杂志文章
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journal_title：Scandinavian journal of immunology
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