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Role of dendritic cells in Sjögren's syndrome.

Abstract：

:Sjögren's syndrome (SS) is a chronic inflammatory and lymphoproliferative autoimmune disease of unknown aetiology. It is characterised by progressive mononuclear cell infiltration of the salivary and lacrimal glands and a decreased glandular secretion, resulting in dryness of the mouth and eyes (xerostomia and keratoconjunctivitis sicca, respectively). Dendritic cells (DC) are considered to be the most potent antigen-presenting cells. Because of their central role in initiating an immune response while maintaining tolerance, impaired function of these cells might lead to the break of peripheral tolerance and initiation of immune responses to self-antigens. This review will focus on the possible role of DC in SS.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Vogelsang P,Jonsson MV,Dalvin ST,Appel S

doi

10.1111/j.1365-3083.2006.01811.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

219-26

issue

3

eissn

0300-9475

issn

1365-3083

pii

SJI1811

journal_volume

64

pub_type

杂志文章

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