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In vitro production of granular T cells and mast cells by use of different conditioned media. Ultrastructural and functional analysis.

Abstract：

:Normal mouse spleen cells were cultured in different conditioned media (CM). Mixed lymphocyte culture supernatant (MLC SN) was shown to promote the proliferation of cytotoxic, Thy-1+, Lyt-1+, Lyt-2+, asialo-GM-1+, weakly adherent cells with numerous vacuoles and lysosome-like cytoplasmic granules. In contrast, the Con A SN induced the proliferation of non-cytotoxic, Thy-1-, Lyt-1-, Lyt-2-, asialo-GM-1-, non-adherent cells with numerous cytoplasmic granules. The ultrastructural morphology of these cells and the cytochemical characteristics of their granules enable us to identify them as mast cells. The different effects of both CM could be related to their T-cell growth factor (TCGF) content. When the amount of TCGF of these two CM was determined (by assaying growth-stimulating activity for T-cell colonies), it appeared that the MLC SN contained larger amounts of TCGF than the Con A SN used in these experiments.

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Courtoy R,Schaaf-Lafontaine N,Degiovanni G,Boniver J

doi

10.1111/j.1365-3083.1983.tb00846.x

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

101-11

issue

2

eissn

0300-9475

issn

1365-3083

journal_volume

18

pub_type

杂志文章

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