Abstract:
:We have previously demonstrated that monoclonal anti-I-A/E antibodies inhibit B-cell responses to lipopolysaccharide (LPS). In the present report, the inhibitory effects were shown to be carried out directly on B cells, and to be totally independent of the LPS concentration used, thereby showing that antibodies do not mediate their effect through blocking of accessory cells or steric hindrance of LPS-receptors. Of the three different phases in B-cell activation/induction, proliferation, and maturation, induction was shown to be the most sensitive to inhibition by anti-I-A/E antibodies. Thus, kinetic studies showed that anti-I-A/E antibodies are only inhibitory for the first 16 h of LPS activation, after which B cells can no longer be inhibited by these antibodies. Class II MHC molecules appear, therefore, to be part of a membrane molecular complex which regulates delivery of activation signals to resting B cells. Since it was also shown that this time period corresponds approximately to the time required for B cells to express functional reactivity to growth factors, we suggest that anti-I-A/E antibodies act on resting B lymphocytes to inhibit mitogen-dependent induction of growth receptor expression.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Forsgren S,Martinez-A C,Coutinho Adoi
10.1111/j.1365-3083.1987.tb01068.xsubject
Has Abstractpub_date
1987-03-01 00:00:00pages
225-34issue
3eissn
0300-9475issn
1365-3083journal_volume
25pub_type
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journal_title:Scandinavian journal of immunology
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