Treatment with anti-TNF alpha does not induce reactivation of latent Salmonella enterica serovar Typhimurium infection in C3H/HeN mice.

Abstract:

:Therapy with tumour necrosis factor-alpha (TNFalpha)-blocking agents is successful in treating inflammatory disorders, but carries an increased risk of manifest and reactivating infection with intracellular bacteria. In a mouse model of latent Salmonella typhimurium infection, neutralization of TNFalpha did not result in reactivation of infection, suggesting only a minor role for TNFalpha during latency of persistent Salmonella infection.

journal_name

Scand J Immunol

authors

van Diepen A,Martina CA,Flierman R,Janssen R,van Dissel JT

doi

10.1111/j.1365-3083.2007.01920.x

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

407-11

issue

5

eissn

0300-9475

issn

1365-3083

pii

SJI1920

journal_volume

65

pub_type

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