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Milk-derived GM(3) and GD(3) differentially inhibit dendritic cell maturation and effector functionalities.

Abstract：

:Gangliosides are complex glycosphingolipids, which exert immune-modulating effects on various cell types. Ganglioside GD(3) and GM(3) are the predominant gangliosides of human breast milk but during the early phase of lactation, the content of GD(3) decreases while GM(3) increases. The biological value of gangliosides in breast milk has yet to be elucidated but when milk is ingested, dietary gangliosides might conceptually affect immune cells, such as dendritic cells (DCs). In this study, we address the in vitro effect of GD(3) and GM(3) on DC effector functionalities. Treatment of bone marrow-derived DCs with GD(3) before lipopolysaccharide-induced maturation decreased the production of interleukin-6 (IL-6), IL-10, IL-12 and tumor necrosis factor-alpha as well as reduced the alloreactivity in mixed leucocyte reaction (MLR). In contrast, only IL-10 and IL-12 productions were significantly inhibited by GM(3,) and the potency of DCs to activate CD4(+) cells in MLR was unaffected by GM(3). However, both gangliosides suppressed expression of CD40, CD80, CD86 and major histocompatibility complex class II on DCs. Because GD(3) overall inhibits DC functionalities more than GM(3), the immune modulating effect of the ganglioside fraction of breast milk might be more prominent in the commencement of lactation during which the milk contains the most GD(3).

journal_name

Scand J Immunol

journal_title

Scandinavian journal of immunology

authors

Brønnum H,Seested T,Hellgren LI,Brix S,Frøkiaer H

doi

10.1111/j.1365-3083.2005.01566.x

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

551-7

issue

6

eissn

0300-9475

issn

1365-3083

pii

SJI1566

journal_volume

61

pub_type

杂志文章

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