Abstract:
:Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selectively produced IFN-κ is identified to be a key to trigger type I interferon responses in CLE. Other immune cells such as plasmacytoid dendritic cells (pDCs) are identified to be relevant origin of type I interferons (type I IFNs) which are central to the development of CLE lesions and responsible for mediating Th1 cell activity. Other types of cells such as neutrophils, B cells and Th17 cells also are involved in the development of this disease. The close interaction of those cells composes a comprehensive and complicated network in CLE. In this review, we discussed the aberrant distribution and function of different cells types involved in this disease and will offer a new direction for research and therapy in the near future.
journal_name
Scand J Immunoljournal_title
Scandinavian journal of immunologyauthors
Zhou X,Yan J,Lu Q,Zhou H,Fan Ldoi
10.1111/sji.12933subject
Has Abstractpub_date
2021-01-01 00:00:00pages
e12933issue
1eissn
0300-9475issn
1365-3083journal_volume
93pub_type
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1998-08-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1981.tb00191.x
更新日期:1981-08-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1988.tb02316.x
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1365-3083.1999.00560.x
更新日期:1999-07-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1046/j.1365-3083.1998.00390.x
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pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1985.tb01877.x
更新日期:1985-09-01 00:00:00
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journal_title:Scandinavian journal of immunology
pub_type: 杂志文章
doi:10.1111/j.1365-3083.1975.tb02619.x
更新日期:1975-01-01 00:00:00