Overexpression of toll-like receptor 3 in spleen is associated with experimental arthritis in rats.

abstract：:T-cell sensitization to indirectly presented alloantigens (indirect pathway of allorecognition) plays a critical role in chronic rejection. The usual very efficient priming of such self-restricted, T helper type 1 (Th1)-deviated CD4+ T cells obviously conflicts with the fact that allogeneic MHC molecules are poorly im...

journal_title：Scandinavian journal of immunology

authors： Wallgren AC,Andersson B,Bäcker A,Karlsson-Parra A

更新日期：2005-09-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic inflammatory and lymphoproliferative autoimmune disease of unknown aetiology. It is characterised by progressive mononuclear cell infiltration of the salivary and lacrimal glands and a decreased glandular secretion, resulting in dryness of the mouth and eyes (xerostomia and keratoc...

journal_title：Scandinavian journal of immunology

authors： Vogelsang P,Jonsson MV,Dalvin ST,Appel S

更新日期：2006-09-01 00:00:00

abstract：:Denaturing high-performance liquid chromatography (DHPLC) was evaluated as a tool for diagnostic screening of polymorphisms in the tumour necrosis factor receptor superfamily member 6 (TNFRSF6) also known as CD95, Apo-1 or Fas gene. Exons 1-9 of the TNFRSF6 gene were amplified from genomic DNA of 38 individuals, of wh...

journal_title：Scandinavian journal of immunology

authors： Etokebe GE,Abrahamsen TG,Bogen B,Spurkland A

更新日期：2004-05-01 00:00:00

abstract：:Monoclonal anti-HLA-DR antibodies inhibited the production of interleukin-2 (IL-2) when added from the initiation of autologous (AMLR) and allogeneic (MLR) mixed lymphocyte reactions, but not 60 h later. The inhibitory activity of the anti-DR sera became apparent 8 h after initiation of the cultures and was maintained...

journal_title：Scandinavian journal of immunology

authors： Palacios R

更新日期：1981-09-01 00:00:00

abstract：:A Gross virus induced rat T cell lymphoma G1-Tc1 and a Moloney virus induced mouse T cell lymphoma YAC-1 are shown to exert a strong cytotoxic activity against rat yolk sac tumours but not to various types of rat, mouse or human normal cells or tumour cell lines including carcinomas, sarcomas, lymphomas and gliomas. B...

journal_title：Scandinavian journal of immunology

authors： Lindvall M,Eriksson H,Hedlund G,Sjögren HO

更新日期：1997-11-01 00:00:00

abstract：:We have studied the interaction of mitogenic lectins such as phytohaemagglutinin (PHA) and concanavalin A (Con A) with both surface molecules which, by the use of monoclonal antibodies, are known to trigger T-cell mitogenesis. Monoclonal antibodies recognizing the T-lymphocyte receptor for antigen (Ti) and/or its asso...

journal_title：Scandinavian journal of immunology

authors： Leca G,Boumsell L,Fabbi M,Reinherz EL,Kanellopoulos JM

更新日期：1986-05-01 00:00:00

abstract：:There is an increasing need for novel biomarkers that enable better diagnostic and prognostic stratification of patients with suspected infection. A proprotein convertase enzyme FURIN is upregulated upon immune cell activation, and it promotes infectivity by cleaving and activating pathogens. In this study, we determi...

journal_title：Scandinavian journal of immunology

authors： Ranta N,Turpeinen H,Oksanen A,Hämäläinen S,Huttunen R,Uusitalo-Seppälä R,Rintala E,Aittoniemi J,Pesu M

更新日期：2015-12-01 00:00:00

abstract：:Bacterial DNA differs from mammalian DNA by the presence of unmethylated cytosine-phosphate-guanosine (CpG) motifs. The immunostimulatory properties of a DNA vaccine have been suspected to be associated with these motifs. The aim of this study was to assess the inactivation of the immunostimulatory potential of a plas...

journal_title：Scandinavian journal of immunology

authors： Cornélie S,Poulain-Godefroy O,Lund C,Vendeville C,Ban E,Capron M,Riveau G

更新日期：2004-02-01 00:00:00

abstract：:The fibril in primary amyloidosis (AL) is composed of a monoclonal light chain or portions thereof. No unique primary structure has been identified that predisposes certain light chains to form amyloid fibrils. Currently, classification of amyloidosis is based on the biochemistry of the amyloid fibril. We determined t...

journal_title：Scandinavian journal of immunology

authors： Gertz MA,Skinner M,Cohen AS,Connors LH,Kyle RA

更新日期：1985-09-01 00:00:00

abstract：:Guinea pig alpha 1-microglobulin (alpha 1-m) was found to exert mitogenic effects on guinea pig lymphocytes, i.e. peritoneal exudate lymphocytes (PEL) or T lymphocytes from regional or mesenteric lymph nodes (LNL). On the other hand, spleen T lymphocytes did not respond to alpha 1-m. Stimulation of LNL required the pr...

journal_title：Scandinavian journal of immunology

authors： Lögdberg L,Akerström B,Shevach EM

更新日期：1986-11-01 00:00:00

abstract：:RNA silencing is an efficient biochemical tool for gene knock downs as well as physiological phenomenon playing a major role in diverse biological processes. Recent knowledge suggests that the same protein families which mediate the experimental RNA interference (RNAi) in the fruit fly Drosophila melanogaster cells al...

journal_title：Scandinavian journal of immunology

authors： Ulvila J,Hultmark D,Rämet M

更新日期：2010-03-01 00:00:00

abstract：:Polymorphonuclear cell function tests were performed in 340 patients with recurrent unexplained infections. Serum-dependent defects in phagocytosis and intracellular killing of Candida albicans (Candida opsonin and procidin defects) were specifically associated with susceptibility to recurrent pyogenic infections, Can...

journal_title：Scandinavian journal of immunology

authors： Parkin JM,Bridges J,Sloper KS,Warner JO,Pinching AJ

更新日期：1991-01-01 00:00:00

abstract：:Glomerular complement receptors (GCR) were demonstrated by the adsorption of C3 coated sheep erythrocytes to cryostat sections of human kidneys. An epithelial localization of the GCR is implied by the binding pattern of the indicator cells. The GCR activity was reduced in all glomeruli where in vivo deposition of immu...

journal_title：Scandinavian journal of immunology

authors： Matre R,Iversen BM,Thunold S,Tønder O

更新日期：1978-01-01 00:00:00

abstract：:The presence of receptors for three human proteins (fibrinogen, IgG, and beta 2-microglobulin (beta 2m)) was studied in group A streptococcal strains. M type 1, 12 and 14, and in M protein-negative variants of these strains. Fibrinogen binding was detected in all six strains. IgG did not bind to the two type-12 strain...

journal_title：Scandinavian journal of immunology

authors： Björck L,Tylewska SK,Wadström T,Kronvall G

更新日期：1981-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease, which is characterized with overactive immune response. It is well established that the imbalance between Tregs and Th17 cells plays a pivotal role in pathogenesis of UC. In this study, we investigated the impact of functional changes in Treg subs...

journal_title：Scandinavian journal of immunology

authors： Long Y,Zhao X,Xia C,Li X,Fan C,Liu C,Wang C

更新日期：2020-06-01 00:00:00

abstract：:The recombinant bacillus Calmette-Guérin (rBCG) secretion system utilizing an extracellular alpha antigen of Mycobacterium kansasii (alpha-K) was characterized biochemically and immunologically. The human immunodeficiency virus type 1 (HIV-1) p17gag B cell epitope fused to alpha-K was secreted in extremely large amoun...

journal_title：Scandinavian journal of immunology

authors： Wada N,Ohara N,Kameoka M,Nishino Y,Matsumoto S,Nishiyama T,Naito M,Yukitake H,Okada Y,Ikuta K,Yamada T

更新日期：1996-02-01 00:00:00

abstract：:BTK and ITK are cytoplasmic tyrosine kinases of crucial importance for B and T cell development, with loss-of-function mutations causing X-linked agammaglobulinemia and susceptibility to severe, frequently lethal, Epstein-Barr virus infection, respectively. Over the last few years, considerable efforts have been made ...

journal_title：Scandinavian journal of immunology

authors： Vargas L,Hamasy A,Nore BF,Smith CI

更新日期：2013-08-01 00:00:00

abstract：:The migration inhibition in vitro induced by measles virus material on leukocytes from 17 patients with multiple sclerosis (MS) was compared with that of 8 patients with various other central nervous system diseases and that of 12 healthy blood donors. Significant differences could not be demonstrated. The results do ...

journal_title：Scandinavian journal of immunology

authors： Nordal HJ,Froland SS,Vandvik B,Norrby E

更新日期：1976-01-01 00:00:00

abstract：:We investigated interferon (IFN) production by peripheral blood mononuclear cells from four patients with chronic OKT4 T-lymphocytic leukaemia and three patients with abnormal expansions of granular lymphocytes. No spontaneous production of IFN-gamma was found in supernatants of cultures from both patients and normal ...

journal_title：Scandinavian journal of immunology

authors： Pandolfi F,Capobianchi M,Matricardi P,Facchini J,Bonomo G,De Rossi G,Semenzato G,Fiorilli M,Dianzani F,Aiuti F

更新日期：1985-04-01 00:00:00

abstract：:The cause of ankylosing spondylitis (AS) remains unelucidated. Both genetic and environmental factors are suspected playing an important role in AS development. Peptidyl arginine deiminase type IV (PADI4) is a member of gene family that encodes enzymes responsible for the conversion of arginine to citrulline residues....

journal_title：Scandinavian journal of immunology

authors： Chen R,Wei Y,Cai Q,Duan S,Lin J,Fang M,Lv K,Cheng N,Sun S

更新日期：2010-11-01 00:00:00

abstract：:We describe a new quantitative fluorimetric assay for phagocytosis of bacteria. A suspension of fluorescein-labelled bacteria (Micrococcus lysodeikticus) is mixed and incubated with phagocytes. After fixation with paraformaldehyde, the excess non-phagocytosed and adsorbed bacteria are lysed with a solution of lysozyme...

journal_title：Scandinavian journal of immunology

authors： Vray B,Hoebeke J,Saint-Guillain M,Leloup R,Strosberg AD

更新日期：1980-01-01 00:00:00

abstract：:T cell-mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune-pathophy...

journal_title：Scandinavian journal of immunology

authors： Aghamajidi A,Raoufi E,Parsamanesh G,Jalili A,Salehi-Shadkami M,Mehrali M,Mohsenzadegan M

更新日期：2020-11-15 00:00:00

abstract：:We have analysed separately the role of B-cell receptor (BCR) stimulation and the soluble second signal in the T-cell-independent type 2 (TI-2) B-cell response. We were able to show that human B cells and macrophages (Mphi) could function together in TI-type microbial response. Interestingly, BCR cross-linking of peri...

journal_title：Scandinavian journal of immunology

authors： Mättö M,Raunio AR,Postila V,Huttunen K,Hirvonen MR,Pelkonen J

更新日期：2008-03-01 00:00:00

abstract：:Peripheral blood mononuclear cells from a donor with a high titre of anti-hepatitis B surface (HBs) antibodies were fused with a cell line that was positive for Epstein-Barr virus nuclear antigen and sensitive to hypoxanthine-aminopterine-thymidine. A cell line was established that produces a monoclonal IgG1 lambda an...

journal_title：Scandinavian journal of immunology

authors： Stricker EA,Tiebout RF,Lelie PN,Zeijlemaker WP

更新日期：1985-09-01 00:00:00

abstract：:CD47 is a versatile cell-surface molecule expressed on nearly all haematopoietic cells. In its capacity as a thrombospondin-1 (TSP-1) receptor, CD47 has recently been shown to mediate cell death in certain cells, for example, activated but not resting T cells. Here, we have investigated the possibility that human mono...

journal_title：Scandinavian journal of immunology

authors： Johansson U,Higginbottom K,Londei M

更新日期：2004-01-01 00:00:00

abstract：:We examined the progression of articular destruction and the production of tumour necrosis factor-alpha (TNF-alpha) in antigen-induced arthritis (AIA) in rabbits, i.e. flare-ups of inflammation induced by repeated intra-articular injections (single, twice and three times) of antigen. A marked progression of articular ...

journal_title：Scandinavian journal of immunology

authors： Idogawa H,Imamura A,Onda M,Umemura T,Ohashi M

更新日期：1997-12-01 00:00:00

abstract：:The binding of human serum amyloid P component (SAP) to blood cells and monocyte-derived dendritic cells was investigated by flow cytometry. Monocytes bound biotinylated SAP with avidity in a dose-dependent and saturable manner. By contrast, the binding of SAP to monocyte-derived dendritic cells was weak. No binding t...

journal_title：Scandinavian journal of immunology

authors： Macdonald SL,Kilpatrick DC

更新日期：2006-07-01 00:00:00

abstract：:Prolonged antigenic stimulation results in lymphocyte shedding of CD27, a member of the tumour necrosis factor receptor (TNFR) family, and transformation to a stable phenotype capable of synthesizing interleukin-4 (IL-4). Co-expression of alpha4beta7 identifies those cells with gut-homing potential. We have investigat...

journal_title：Scandinavian journal of immunology

authors： Meenan J,Spaans J,Grool TA,Lammers K,Pals S,Tytgat GN,van Deventer SJ

更新日期：1998-09-01 00:00:00

abstract：:In a well-established murine abortion model, stress is thought to trigger fetal rejection by inducing a proinflammatory immune response via substance P (SP), being tumour necrosis factor (TNF)-alpha-producing CD8+ T cells involved. Interestingly, the SP metabolite SP5-11 also binds to SP receptors and mediates SP-like...

journal_title：Scandinavian journal of immunology

authors： Fest S,Zenclussen AC,Joachim R,Hagen E,Demuth HU,Hoffmann T

更新日期：2006-01-01 00:00:00

abstract：:Atrial fibrillation is highly prevalent, and affected patients are at an increased risk of a number of complications, including heart failure and thrombo-embolism. Over the past years, there has been increasing interest in the role of inflammatory processes in atrial fibrillation, from the first occurrence of the arrh...

journal_title：Scandinavian journal of immunology

authors： Lappegård KT,Hovland A,Pop GA,Mollnes TE

更新日期：2013-08-01 00:00:00